Method for treating retinal conditions using an intraocular tamponade
A composition includes at least one fatty acid glycerol ester for use during or after a vitrectomy procedure, the composition being bioresorbable, being injectable in the vitreous cavity, having a density below 1, more preferably between 0.90 and 1, or a density above 1, more preferably between 1 and 1.5; having a surface tension of less than 50 dynes/cm more preferably ranging from 20 and 30 dynes/cm, being not susceptible to emulsify into droplets when injected; method for treating a retinal disorder involving the use of the composition.
1. A method for treating retinal disorders, comprising,
injecting into the vitreous cavity of a subject in need thereof, during or after a vitrectomy procedure, a non-emulsified tamponade composition comprising at least 90% w/w of one or more C6-C20 fatty acid glycerol ester,
said tamponade composition having a surface tension of less than 50 dynes/cm, and a density of less than 1, and
said tamponade remaining non-emulsified while in the vitreous cavity,
wherein said retinal disorders are retinal detachment, break or tear; complications or bleeding from diabetic eye disease; clouding of vitreous jelly from one of many causes including blood, inflammatory debris or infection; macular hole; epiretinal membrane; consequences of entry or passing of a foreign body through an eye; or intraocular infections.
2. The method according to claim 1 , wherein the composition has a density between 0.90 and less than 1.
3. The method according to claim 1 , wherein the composition has a dynamic viscosity ranging from 20 to 60 mPa·s at a temperature of 20° C.
4. The method according to claim 1 , wherein the composition has a refractive index ranging from 1.40 to 1.50.
5. The method according to claim 1 , wherein the composition further comprises at least one lipophilic therapeutic agent.
6. The method according to claim 5 , wherein the composition comprises the therapeutic agent in an amount of more than 0 to 5.9% w/w, in weight to the weight of total composition, the therapeutic agent being dissolved in the fatty acid glycerol ester.
7. The method according to claim 1 , comprising at least 90% w/w of at least one C6-C12 fatty acid glycerol ester.
8. The method according to claim 1 , comprising
removing the vitreous fluid of the subject prior to injecting the tamponade composition into the vitreous cavity, and
injecting from 0.1 ml to 10 ml of the tamponade composition into the vitreous cavity.
9. The method according to claim 1 , wherein said tamponade composition has a surface tension of 20 to 30 dynes/cm.
10. The method according to claim 1 , wherein the tamponade composition is injected into the vitreous cavity during a vitrectomy procedure.
11. The method according to claim 1 , wherein the retinal disorder is a retinal detachment, break, tear or hole.
12. The method according to claim 1 , wherein the tamponade composition comprises at least 95% of medium chain triglycerides.
13. The method according to claim 1 , wherein the tamponade composition comprises at least 99% of medium chain triglycerides.
14. The method according to claim 1 , wherein the tamponade composition comprises non-fluorinated fatty acid glycerol esters.
15. The method according to claim 1 , wherein the tamponade composition comprises at least 90% w/w of one or more C6-C20 non-fluorinated fatty acid glycerol ester.
16. The method according to claim 1 , wherein the tamponade composition comprises at least 98% w/w of one or more C6-C20 non-fluorinated fatty acid glycerol ester selected from medium chain triglycerides, castor oil and olive oil.
17. The method according to claim 8 , wherein the tamponade composition is injected into the vitreous cavity with a 27 to 30 gauge needle.