IP Library Granted Patent US 9,623,224
Granted Patent B2
US 9,623,224 · App. 14/216,522 · Granted Apr 18, 2017

Systems and methods of stimulation and activation of fluids for use with instillation therapy

Inventors: Christopher Brian Locke (Bournemouth, GB); Timothy Mark Robinson (Basingstoke, GB); Richard Daniel John Coulthard (Verwood, GB)
Assignee: KCI LICENSING, INC.
A61M35/00A61F13/00068A61M1/0088A61N5/062A61K41/00A61M1/0058A61M1/0084A61N5/02
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Quick Facts
Patent No.
US 9,623,224
App. No.
14/216,522
Granted
Apr 18, 2017
Kind
B2
Abstract

Systems and methods of stimulating or activating fluids for use in wound treatment systems.

Claims (46)

1. A wound treatment system comprising:

a wound dressing;

a fluid storage device configured to deliver a fluid to the wound dressing, the fluid comprising a therapeutic agent; and

an energy source configured to direct energy to the fluid and to activate the therapeutic agent.

2. The wound treatment system of claim 1 , wherein the fluid comprises molecules with a protective coating prior to exposure to the energy source.

3. The wound treatment system of claim 2 , wherein the energy source is configured to degrade the protective coating.

4. The wound treatment system of claim 2 , wherein the energy source is configured to activate a component of the fluid that degrades the protective coating.

5. The wound treatment system of claim 2 , wherein the protective coating comprises a bioabsorbable glass.

6. The wound treatment system of claim 2 , wherein the protective coating comprises a ceramic.

7. The wound treatment system of claim 1 , wherein the energy source emits ultrasonic energy.

8. The wound treatment system of claim 1 , wherein the energy source emits magnetic energy.

9. The wound treatment system of claim 1 , wherein the energy source emits radio frequency energy.

10. The wound treatment system of claim 1 , wherein the energy source emits ionizing radiation energy.

11. The wound treatment system of claim 1 , wherein the energy source emits microwave energy.

12. The wound treatment system of claim 1 , wherein the energy source is configured to direct energy to the fluid proximal to the wound dressing.

13. The wound treatment system of claim 1 , further comprising a conduit in fluid communication with the fluid storage device and the wound dressing.

14. The wound treatment system of claim 13 , wherein the energy source is configured to direct energy to the fluid in the conduit.

15. The wound treatment system of claim 1 , wherein the therapeutic agent comprises property includes an anti-biotic property.

16. The wound treatment system of claim 1 , wherein the therapeutic property includes an analgesic property.

17. The wound treatment system of claim 1 , wherein the therapeutic property aids with debridement of tissue.

18. The wound treatment system of claim 1 , wherein the therapeutic property improves the ability to remove the wound dressing from a wound.

19. The wound treatment system of claim 1 , wherein the therapeutic property reduces biofilm buildup in a wound.

20. A method of treating a wound, the method comprising:

applying a wound dressing to the wound;

providing a fluid storage device and a conduit in fluid communication with the wound dressing;

transporting a fluid to the wound dressing, the fluid comprising a therapeutic agent; and

directing energy to the fluid when the fluid is in the conduit to activate the therapeutic agent.

21. The method of claim 20 , further comprising applying a negative pressure to the wound dressing.

22. The method of claim 20 , further comprising coupling a coupling member to the conduit and the wound dressing.

23. The method of claim 22 , wherein the energy is directed to the fluid at the coupling member.

24. The method of claim 20 , wherein the fluid comprises molecules having a coating and an active agent, and wherein directing energy to the fluid breaks down the coating.

25. A wound treatment system comprising:

a wound dressing;

a fluid storage device in fluid communication with the wound dressing;

a fluid comprising molecules with at least one type of therapeutic agent; and

an energy source configured to direct energy to the fluid to cause activation of the therapeutic agent of the fluid.

26. The wound treatment system of claim 25 , wherein the fluid comprises an anti-microbial agent.

27. The wound treatment system of claim 26 , wherein the anti-microbial agent is hypochlorous acid (HOCl) or hypochlorite ion (ClO − ).

28. The wound treatment system of claim 25 , wherein the fluid further comprises molecules with a protective coating prior to exposure to the energy source.

29. The wound treatment system of claim 28 , wherein the protective coating comprises a plurality of layers of polyallylamine hydrochloride (PAH) and polysodium 4-styrenesulfonate (PSS).

30. The wound treatment system of claim 25 , wherein the molecules include an active agent and are constructed so that the active agent is inhibited by a light-sensitive branch, which when broken, thereby activates the active agent.

31. The wound treatment system of claim 25 , wherein the fluid comprises molecules having an active agent and constructed so that the active agent is controlled by photoinhibition.

32. The wound treatment system of claim 25 , wherein the fluid comprises molecules having an active agent that is a clotting agent.

33. The wound treatment system of claim 32 , wherein the clotting agent is a trivalent salt, such as Fe +++ or Al +++ .

34. The wound treatment system of claim 33 , wherein the Fe +++ compound is encapsulated in a glucose sensitive microcapsule, which increases in permeability to allow for the release of the Fe +++ agent upon encountering glucose.

35. The wound treatment system of claim 25 , wherein the fluid comprises multiple agents which are activated by different wavelengths of light or frequencies of energy.

Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2024
From: 3M INNOVATIVE PROPERTIES COMPANY
To: SOLVENTUM INTELLECTUAL PROPERTIES COMPANY
Reel/Frame 066444/0162 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2023
From: KCI LICENSING, INC.
To: 3M INNOVATIVE PROPERTIES COMPANY
Reel/Frame 064718/0544 →
RELEASE OF SECURITY INTEREST IN PATENTS Recorded Nov 7, 2019
From: WILMINGTON TRUST, NATIONAL ASSOCIATION
To: KCI USA, INC.; KCI LICENSING, INC.
Reel/Frame 050966/0547 →
RELEASE OF SECURITY INTEREST REEL/FRAME 040098/0268 Recorded Feb 8, 2017
From: WILMINGTON TRUST
To: KCI USA, INC.
Reel/Frame 041666/0320 →
LIMITED THIRD LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Oct 7, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040291/0237 →
SECOND LIEN SECURITY AGREEMENT Recorded Sep 21, 2016
From: KCI USA, INC.; LIFECELL CORPORATION; KCI LICENSING, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 040098/0268 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 15, 2016
From: LOCKE, CHRISTOPHER; ROBINSON, TIM; COULTHARD, RICHARD
To: KCI LICENSING, INC
Reel/Frame 038921/0950 →
Continuity (3)
Continuation 13477741 · May 22, 2012
Provisional Application 61490150 · May 26, 2011
Related Publication 20140200526A1 · Jul 17, 2014