Drug delivery compositions
The present invention relates material that is useful in drug delivery compositions. The material comprises cellulose nanofibers and/or derivatives thereof, wherein the cellulose nanofibers are in a form of a hydrogel or membrane. The invention also provides methods for producing these materials and compositions and uses thereof.
1. A drug delivery composition, characterized in that the composition comprises plant derived cellulose nanofibers and/or derivatives thereof and a drug or medicament, wherein the plant derived cellulose nanofibers and/or derivatives thereof are in the form of a hydrogel and said cellulose nanofibers are obtained by mechanical disintegration, said hydrogel being a direct product of homogenization of said cellulose nanofibers, wherein the delivery of the drug or medicament is controlled by diffusion through the hydrogel.
2. The composition according to claim 1 , characterized in that the cellulose nanofiber derivatives comprise chemically or physically modified derivatives of cellulose nanofibers or nanofiber bundles.
3. The composition according to claim 1 , characterized in that the composition is a topical, subcutaneous, intramuscular or intraocular composition.
4. The composition according to claim 1 , wherein the drug or medicament is incorporated in the hydrogel as an aqueous solution or dispersion.
5. The composition according to claim 1 , wherein the composition comprises about 0.05-20 wt percent of cellulose nanofibers and about 0.001-20 wt percent of the drug or medicament and water.
6. The composition according to claim 1 , wherein the composition is injectable.
7. The composition according to claim 6 , wherein the plant derived cellulose is native grade.
8. The composition of claim 1 , wherein the cellulose nanofibers are configured to form a gel network at 0.5% by weight.
9. The composition of claim 1 , wherein the composition comprises 0.5-4% by weight of plant derived cellulose nanofibers and/or derivatives thereof.
10. The composition of claim 1 , wherein the diameter of cellulose nanofibers and/or derivatives thereof or nanofiber bundles in the cellulose nanofibers is less than 200 nm.
11. The composition of claim 1 , wherein the diameter of cellulose nanofibers and/or derivatives thereof or nanofiber bundles in the cellulose nanofibers is less than 100 nm.
12. The composition of claim 1 , wherein the diameter of the cellulose nanofibers and/or derivatives thereof is less than 1 μm.
13. The composition of claim 1 , wherein the hydrogel is configured to be used without any substantial modifications in drug delivery in vivo.
14. The composition of claim 1 , wherein the storage modulus of the hydrogel is at least one order of magnitude higher than the loss modulus of the hydrogel.
15. The composition of claim 1 , wherein the hydrogel is opaque, and the homogenization includes high pressure homogenization of the cellulose nanofibers, the cellulose nanofibers being wet cellulose nanofibers.
16. The composition of claim 1 , wherein the hydrogel is transparent, and the cellulose nanofibers are chemically modified.