Isotopologues of isoindole derivatives
Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.
1. A method of treating arthritis, osteoarthritis, inflammatory bowel disease, ankylosing spondylitis, rosacea, acne, pain, sarcoidosis, psoriasis, dermatitis, or chronic obstructive pulmonary disease, comprising administering to a patient a compound which is:
or a pharmaceutically acceptable salt thereof, wherein:
at least one of Y 1 -Y 25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y 1 -Y 25 are non-enriched hydrogen atoms.
2. The method of claim 1 , wherein the compound is an (S)-isomer having a structure:
3. The method of claim 1 , wherein one to five of Y 1 -Y 25 of the compound is isotopically enriched with deuterium, and the others are non-enriched hydrogens.
4. The method of claim 1 , wherein six to ten of Y 1 -Y 25 of the compound are isotopically enriched with deuterium, and the others are non-enriched hydrogens.
5. The method of claim 1 , wherein eleven to fifteen of Y 1 -Y 25 of the compound are isotopically enriched with deuterium, and the others are non-enriched hydrogens.
6. The method of claim 1 , wherein sixteen to twenty of Y 1 -Y 25 of the compound are isotopically enriched with deuterium, and the others are non-enriched hydrogens.
7. The method of claim 1 , wherein twenty one to twenty five of Y 1 -Y 25 of the compound are isotopically enriched with deuterium, and the others are non-enriched hydrogens.
8. The method of claim 1 , wherein the inflammatory bowel disease is Crohn's disease or ulcerative colitis.
9. The method of claim 1 , wherein the arthritis is psoriatic arthritis, acute gouty arthritis, or rheumatoid arthritis.
10. The method of claim 1 , wherein the dermatitis is atopic dermatitis or contact dermatitis.
11. The method of claim 1 , further comprising administering a second active agent.
12. A method of treating psoriasis comprising administering to a patient a compound which is:
or a pharmaceutically acceptable salt thereof, wherein:
at least one of Y 1 -Y 25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y 1 -Y 25 are non-enriched hydrogen atoms.
13. The method of claim 12 , wherein the compound is an (S)-isomer having a structure:
14. The method of claim 12 , further comprising administering a second active agent.
15. A method of treating sarcoidosis comprising administering to a patient a compound which is:
or a pharmaceutically acceptable salt thereof, wherein:
at least one of Y 1 -Y 25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y 1 -Y 25 are non-enriched hydrogen atoms.
16. The method of claim 15 , wherein the compound is an (S)-isomer having a structure:
17. The method of claim 15 , further comprising administering a second active agent.