Allosteric modulators of EGFR and constitutively active mutants
The present invention includes a novel class of allosteric modulators that target a protein having a juxtamembrane segment. In another embodiment, the allosteric modulator is a peptide mimetic that is capable of interacting with an α-helix or a coiled coil domain of a protein. In one embodiment, the peptide mimetic binds to at least an α-helix or a coiled coil domain of EGFR and modulates its activity.
1. An isolated peptide that inhibits an activity of an epidermal growth factor receptor family protein, wherein the isolated peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 3, 5, and 17.
2. The peptide of claim 1 , wherein the peptide comprises a hydrocarbon staple formed between the two unnatural amino acids of SEQ ID NOs: 3, 5, or 17.
3. The peptide of claim 1 , wherein the peptide does not comprise a hydrocarbon staple formed between the two unnatural amino acids of SEQ ID NOs: 3, 5, or 17.