Use for
Provided is a 15-PGDH activity adjusting function of a Dendropanax morbifera extract. More specifically, since it has been confirmed that the Dendropanax morbifera extract has an outstanding effect in suppressing 15-PGDH activity and so increasing PGE 2 , a composition of the present invention which contains the Dendropanax morbifera extract as an active ingredient has the advantage of being able to be used for producing a functional health food and a therapeutic agent for a disease associated with PGE 2 .
1. A method for treating a condition associated with activity of 15-PGDH (15-Hydroxyprostaglandin Dehydrogenase) or prostaglandin E 2 (PGE 2 ), the method comprising orally administering Dendropanax morbifera leaf extract to a subject in need thereof, wherein the condition is peptic ulcer or gastritis.
2. The method of claim 1 , wherein the Dendropanax morbifera extract is a crude extract of Dendropanax morbifera Lev., a polar solvent soluble extract, or a non-polar solvent soluble extract.
3. The method of claim 2 , wherein the crude extract is obtained by using a solvent selected from the group consisting of water including purified water, methanol, ethanol, butanol or a mixed solvent thereof.
4. The method of claim 2 , wherein the polar solvent soluble extract is obtained by using a solvent selected from the group consisting of water, ethanol, butanol or a mixed solvent thereof.
5. The method of claim 2 , wherein the non-polar solvent soluble extract is obtained by using hexane, chloroform, dichloromethane, or ethyl acetate.
6. The method of claim 1 , wherein the Dendropanax morbifera extract has effects on:
(i) inhibition of enzymatic activity of 15-PGDH;
(ii) intracellular and extracelluar increases of PGE 2 ;
(iii) increase in gene expression of COX-1 (cyclooxygenase-1) and MRP4 (multidrug resistance-associated protein 4);
(iv) inhibition of PGT (prostaglandin transporter) expression; and
(v) inhibition of 5α reductase expression.