IP Library › Granted Patent US 9,669,045
Granted Patent B2
US 9,669,045 · App. 14/286,860 · Granted Jun 6, 2017

Treatments for actinic keratoses

Inventor: Lawrence Moy (Manhattan Beach, CA)
Assignee: Lawrence Moy
A61K31/7036A61K9/06A61K31/165
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Quick Facts
Patent No.
US 9,669,045
App. No.
14/286,860
Granted
Jun 6, 2017
Kind
B2
Abstract

A composition of gentamicin and colchicine in a dermatologically acceptable cream base provided improved clearance of actinic keratoses following topical application for 1 to 3 months. The composition provides improved clearance of recalcitrant actinic keratoses. Furthermore, the treatment causes less pain and irritation than other topical treatments for actinic keratoses.

Claims (11)

1. A composition for the topical treatment of actinic keratoses comprising between 0.1% by weight and 1.0% by weight gentamicin and between 0.1% by weight and 1.0% by weight colchicine in a pharmaceutically acceptable cream base composition.

2. The composition according to claim 1 comprising about 1.0% by weight gentamicin and about 0.1% by weight colchicine.

3. The composition according to claim 1 comprising about 0.3% by weight gentamicin and about 0.2% by weight colchicine.

4. A method for treatment of actinic keratoses comprising the step of periodically topically applying an aminoglycoside antibiotic in a pharmaceutically acceptable cream base composition to actinic keratoses.

5. The method according to claim 4 , wherein the aminoglycoside antibiotic is gentamicin.

6. The method according to claim 4 , wherein a drug that binds to tubulin is added to said composition.

7. The method according to claim 6 , wherein application of the composition of an aminoglycoside antibiotic and a tubulin binding drug is alternated with the composition containing only aminoglycoside antibiotic.

8. The method according to claim 6 , wherein the drug that binds to tubulin is colchicine.

9. The method according to claim 8 , wherein the composition comprises between 0.1% by weight and 1.0% by weight gentamicin and between 0.1% by weight and 1.0% by weight colchicine.

10. The method according to claim 9 , wherein the composition comprises 1.0% by weight gentamicin and 0.1% by weight colchicine.

11. The method according to claim 9 , wherein the composition comprises about 0.3% by weight gentamicin and about 0.2% by weight colchicine.

Continuity (3)
Continuation 13462681 · May 2, 2012
Provisional Application 61592532 · Jan 30, 2012
Related Publication 20140256667A1 · Sep 11, 2014