Furopyridines as bromodomain inhibitors

1. A compound of formula (I):

wherein:

V is N or C—R 2

W is N or C—R 8 ;

X is N, CH or C(CH 3 );

Y is N or C—R 5 ;

Z is N or C—R 15 ;

Q is N or CH;

R 1 is C 1-4 alkyl or deuterated C 1-4 alkyl;

R 2 , when present, is H, OH, C 1-4 alkyl, halo, —CF 3 , —NH 2 , —OC 1-4 alkyl, —NHC(O)H, —NHC(O)C 1-4 alkyl, —N(CH 3 )C(O)C 1-4 alkyl, —NHC(O)NH 2 , —NHC(O)C 1-4 alkyleneNH 2 , —N(CH 3 )C(O)NH 2 , —N(CH 3 )C(O)C 1-4 alkyleneNH 2 , —NHC 2-4 alkyleneOCH 3 , —N(CH 3 )C 2-4 alkyleneOCH 3 , —OC 2-4 alkyleneOCH 3 , —OC 2-4 alkyleneOH or

R 2 is a group selected from -G-CH 2 CH(R 3 )(R 4 ), -G-CH(R 3 )(R 4 ) and -G-R 3 in which

G is NH, N(CH 3 ), O, C(O)NH or NHC(O);

R 3 is phenyl, pyridinyl, C 3-7 cycloalkyl or a heterocycle optionally substituted by ═O; and

R 4 is H or C 1-4 alkyl;

R 5 , when present, is H, C 1-4 alkyl, halo, —CF 3 , CN, OH, —OC 1-4 alkyl, —CH 2 NH 2 , —OCF 3 , —SO 2 CH 3 , —C(O)NHC 1-4 alkyl or —CO 2 H;

R 6 is —NR 11 R 12 or a group

D is CH or N;

E is N, O, CH or SO 2 ;

R 7 , when present, is H, OH, C 1-4 alkyl, —NH 2 , —SO 2 C 1-4 alkyl, —SO 2 phenyl, —SO 2 benzyl, —SO 2 N(CH 3 ) 2 , —NHSO 2 CH 3 , —C(O)C 1-4 alkyl, —C(O)phenyl;

R 8 , when present, is H, C 1-4 alkyl, halo, —CF 3 , CN, OH, —OC 1-4 alkyl, —OC 2-4 alkyleneOC 1-4 alkyl, —OCF 3 , —OC 1-4 alkyleneF, —OC 1-4 alkyleneCHF 2 , —OC 2-4 alkyleneOH, —Ophenyl, —OC 1-4 alkylenephenyl, —NHC 3-7 cycloalkyl, —NHC 1-4 alkyleneC 3-7 cycloalkyl, —OC 3-7 cycloalkyl, —OC 1-4 alkyleneC 3-7 cycloalkyl, —NHC 4-6 heterocycle-NHC 1-4 alkyleneC 4-6 heterocycle, —OC 4-6 heterocycle or —OC 1-4 alkyleneC 4-6 heterocycle wherein the C 3-7 cycloalkyl or the C 4-6 heterocycle are each optionally substituted by one or two substituents independently selected from halo, OH, oxo, C 1-4 alkyl and —NH 2 ; or

R 8 and R 2 together with the carbon atoms to which they are attached, form 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine optionally substituted by oxo;

R 9 is H, C 1-4 alkyl, —C(O)NH 2 , —CO 2 CH 3 , —CF 3 , halo, OH, —OC 1-4 alkyl, —CH 2 OH, —C(O)NHCH 3 , —C(O)NH(CH 3 ) 2 , —CH 2 OC 1-4 alkyl or —CH 2 OCH 2 C 3-7 cycloalkyl;

R 10 is H, C 1-4 alkyl, —C(O)NH 2 , —CO 2 CH 3 , —CF 3 , halo, OH, —OC 1-4 alkyl or oxo;

R 11 is H, C 1-4 alkyl or SO 2 CH 3 ;

R 12 is H, C 1-4 alkyl, C 2-4 alkyleneNHR 13 , SO 2 CH 3 , a heterocycle or a heterocycle comprising SO 2 ;

R 13 is H or SO 2 CH 3 ;

R 14 is H or C 1-4 alkyl;

R 15 is H, C 1-4 alkyl or NHC(O)C 1-4 alkyl;

R 16 is H or C 1-4 alkyl: and

n and m are each an integer independently selected from 0, 1 and 2; subject to proviso that no more than 2 of V, W, X, Y and Z are N; or a salt thereof.

2. A compound or a salt thereof according to claim 1 wherein V is C—R 2 and W is C—R 8 .

3. A compound or a salt thereof according to claim 1 wherein R 8 is H, OH, —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OCH 2 CH 2 OCH 3 , —OCH 2 CH(CH 3 )OCH 3 , —OCH(CH 3 )CH 2 OCH 3 , —OCH 2 CH 2 F, —OCH 2 CHF 2 , —OCH 2 CH 2 OH, —NHCH 2 cyclopropyl, —Ocyclopropyl, —OCH 2 cyclopropyl, —Otetrahydrofuranyl, —Ooxetanyl, —OCH 2 tetrahydrofuranyl, —OCH 2 oxetanyl or —OCH 2 CH 2 pyrrolidinyl, wherein the C 3-7 cycloalkyl or the C 4-6 heterocycle are each optionally substituted by one or two substituents independently selected from fluoro and oxo.

4. A compound or a salt thereof according to claim 1 wherein X is CH; Y is N; Z is CH; and Q is CH.

5. A compound or a salt thereof according to claim 1 wherein R 1 is methyl.

6. A compound or a salt thereof according to claim 1 wherein R 2 is H, —OC 1-4 alkyl, —NHC(O)C 1-4 alkyl or —N(CH 3 )C(O)C 1-4 alkyl.

7. A compound or a salt thereof according to claim 1 wherein R 6 is a group

8. A compound or a salt thereof according to claim 1 wherein D is N and E is N, O or CH.

9. A compound or a salt thereof according to claim 1 wherein R 7 is —SO 2 CH 3 .

10. A compound selected from:

7-[3,4-bis(methyloxy)phenyl]-5-methyl-2-{[4-(methylsulfonyl)-1-piperazinyl]methyl}furo[3,2-c]pyridin-4(5H)-one;

(R)—N-(4-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

7-(3-(benzyloxy)phenyl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-(benzylamino)phenyl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

2-(((2-aminoethyl)amino)methyl)-7-(3,4-dimethoxyphenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one;

7-(4-(aminomethyl)phenyl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-1-ylmethyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3,4-dimethoxyphenyl)-5-methyl-2-(morpholinomethyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3,4-dimethoxyphenyl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

2-((1,4-diazepan-1-yl)methyl)-7-(3,4-dimethoxyphenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)furo[3,2-c]pyridin-4(5H)-one;

2-((3,3-difluoropiperidin-1-yl)methyl)-5-methyl-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-((1-phenylethyl)amino)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((1-phenylethyl)amino)phenyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3,4-dimethoxyphenyl)-5-methyl-2-((3-methylmorpholino)methyl)furo[3,2-c]pyridin-4(5H)-one;

N-(4-(2-((3-fluoropiperidin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((3,3-difluoropiperidin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

2-((3-fluoropiperidin-1-yl)methyl)-7-(4-methoxyphenyl)-5-methylfuro[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(morpholinomethyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(S)-5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

2-((1,4-oxazepan-4-yl)methyl)-5-methyl-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(2-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)—N-(4-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)cyclopropanecarboxamide;

(R)—N-(4-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)propionamide;

(R)-7-(2-(2-methoxyethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-(2-(pyrrolidin-1-yl)ethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

2-((1,1-dioxidothiomorpholino)methyl)-5-methyl-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[2,3-d]pyridazin-4(5H)-one;

(R)—N-methyl-N-(4-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3,4-dimethoxyphenyl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[2,3-d]pyridazin-4(5H)-one;

2-((1,4-diazepan-1-yl)methyl)-5-methyl-7-(2-((pyridin-2-ylmethyl)amino)pyridine-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-(2-(2-oxopyrrolidin-1-yl)ethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

N-(4-(5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(R)—N-(4-(5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(S)—N-(4-(5-methyl-2-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(R)—N-(5-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-3-yl)acetamide;

7-(3-((cyclopropylmethyl)amino)pyridin-4-yl)-5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-((cyclopropylmethyl)amino)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(oxetan-2-ylmethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((R)-oxetan-2-ylmethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((S)-oxetan-2-ylmethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-(cyclopropylmethoxy)pyridin-2-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((2-methylpiperazin-1-yl)methyl)-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one hydrochloride;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(oxetan-3-ylmethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

2-((4-acetyl-2-methylpiperazin-1-yl)methyl)-5-methyl-7-(2-((tetrahydro-2H-pyran-4-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one hydrochloride;

N-(3-(5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)phenyl)acetamide;

(R)-7-(2-((cyclopropylmethyl)amino)pyridin-3-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-aminophenyl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

2-((1,4-diazepan-1-yl)methyl)-5-methyl-7-(3-((pyridin-2-ylmethyl)amino)phenyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-ethoxypyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

N-(3-(2-((1,4-diazepan-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)phenyl)picolinamide;

(R)—N-(6-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

2-((1,4-diazepan-1-yl)methyl)-7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methylfuro[3,2-c]pyridin-4(5H)-one;

7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((4-methyl-1,4-diazepan-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-((4-methyl-1,4-diazepan-1-yl)methyl)-7-(3-((pyridin-2-ylmethyl)amino)phenyl)furo[3,2-c]pyridin-4(5H)-one hydrochloride;

(R)-7-(3-isopropoxypyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(2-aminopyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-hydroxypyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-((2,2-difluorocyclopropyl)methoxy)pyridin-4-yl)-5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)—N-(4-(5-( 2 H 3 )methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(2-(2-oxopyrrolidin-1-yl)ethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-amino-N-(3-(5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)phenyl)pentanamide;

N-(4-(5-methyl-2-(2-(4-(methylsulfonyl)piperazin-1-yl)propan-2-yl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(R)-7-(3-(2-methoxyethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

3-(cyclopropylmethoxy)-4-(5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)benzoic acid;

3-(cyclopropylmethoxy)-N-ethyl-4-(5-methyl-2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)benzamide;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((tetrahydrofuran-3-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((3-oxopiperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-(2-fluoroethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-cyclopropoxypyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-(2,2-difluoroethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-7-(3-(2-hydroxyethoxy)pyridin-4-yl)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-(cyclopropylmethoxy)pyridin-4-yl)-5-methyl-2-((4-methyl-3-oxopiperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-(2-methoxypropoxy)pyridin-4-yl)-5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

7-(3-((1-methoxypropan-2-yl)oxy)pyridin-4-yl)-5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)furo[3,2-c]pyridin-4(5H)-one;

(R)-5-methyl-2-((2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(oxetan-3-yloxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((tetrahydrofuran-3-yl)oxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(((S)-tetrahydrofuran-3-yl)oxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one; and

5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-(((R)-tetrahydrofuran-3-yl)oxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one;

N-(4-(5-methyl-4-oxo-2-((5-oxo-1,4-diazepan-1-yl)methyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((1,4-oxazepan-4-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-methylpiperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-methyl-1,4-diazepan-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((1,4-diazepan-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((1,1-dioxidothiomorpholino)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-4-oxo-2-((3-oxopiperazin-1-yl)methyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-(methylsulfonamido)piperidin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(S)—N-(4-(2-((3-hydroxypiperidin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-4-oxo-2-(piperazin-1-ylmethyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((4-ethyl-3-oxopiperazin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-(methylsulfonyl)piperidin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-(((1,1-dioxidotetrahydro-2H-thiopyran-3-yl)amino)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-(((1,1-dioxidotetrahydrothiophen-3-yl)amino)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((2,5-dimethyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((4-ethyl-2-methylpiperazin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-methyl-5-oxo-1,4-diazepan-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((7-methyl-5-oxo-1,4-diazepan-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((2-methyl-5-oxo-1,4-diazepan-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((1,1-dioxido-1,4-thiazepan-4-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((3-methyl-1,1-dioxidothiomorpholino)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((2-methyl-1,1-dioxidothiomorpholino)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((4-acetyl-1,4-diazepan-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-(morpholinomethyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((4-acetyl-2-methylpiperazin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-methyl-3-oxopiperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(S)—N-(4-(5-methyl-2-((3-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-2-((4-(methylsulfonyl)-2-oxopiperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(2-((4-ethylpiperazin-1-yl)methyl)-5-methyl-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-4-oxo-2-(pyrrolidin-1-ylmethyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide

N-(4-(5-methyl-4-oxo-2-(piperidin-1-ylmethyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

N-(4-(5-methyl-4-oxo-2-((3-oxo-1,4-diazepan-1-yl)methyl)-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

(R)—N-(4-(5-methyl-2-((2-methyl-3-oxopiperazin-1-yl)methyl)-4-oxo-4,5-dihydrofuro[3,2-c]pyridin-7-yl)pyridin-2-yl)acetamide;

or a salt thereof.

11. A compound which is 5-methyl-2-(((R)-2-methyl-4-(methylsulfonyl)piperazin-1-yl)methyl)-7-(3-((R)-oxetan-2-ylmethoxy)pyridin-4-yl)furo[3,2-c]pyridin-4(5H)-one or a salt thereof.

12. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition which comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 12 and one or more pharmaceutically acceptable carriers, diluents or excipients.