Antithrombogenic hollow fiber membranes and filters
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
1. A blood tubing comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said blood tubing is antithrombogenic when contacted with blood, as measured by y-count, and wherein said surface modifying macromolecule is described by formula:
F T —[B-(Oligo)] n -B—F T , (VII)
wherein
(i) Oligo is polypropylene oxide having a theoretical molecular weight of from 500 to 2,000 Daltons;
(ii) B is a hard segment formed from hexamethylene diisocyanate;
(iii) F T is a polyfluoroorgano group; and
(iv) n is an integer from 1 to 10.
2. The blood tubing of claim 1 , wherein said base polymer comprises polyvinyl chloride.
3. The blood tubing of claim 1 , wherein n is an integer from 1 to 3.
4. The blood tubing of claim 1 , wherein F T is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da.
5. The blood tubing of claim 1 , wherein F T is CF 3 (CF 2 ) r CH 2 CH 2 —, wherein r is 2-20.
6. The blood tubing of claim 1 , wherein F T is CF 3 (CF 2 ) s (CH 2 CH 2 O) x —, wherein X is 1-10 and s is 1-20.
7. The blood tubing of claim 1 , wherein F T is CH m F (3−m) (CF 2 ) r CH 2 CH 2 — or CH m F (3−m) (CF 2 ) s (CH 2 CH 2 O) x —, wherein m is 0, 1, 2, or 3; X is an integer between 1-10; r is an integer between 2-20; and s is an integer between 1-20.
8. The blood tubing of claim 1 , wherein F T is formed from 1H,1H,2H,2H-perfluoro-1-decanol;
1H,1H,2H,2H-perfluoro-1-octanol; 1H,1H,5H-perfluoro-1-pentanol; or 1H,1H, perfluoro-1-butanol, or a mixture thereof.
9. The blood tubing of claim 8 , wherein F T is formed from 1H,1H,2H,2H-perfluoro-1-octanol.
10. The blood tubing of claim 1 , wherein F T is (CF 3 )(CF 2 ) 5 CH 2 CH 2 O—, (CF 3 )(CF 2 ) 7 CH 2 CH 2 O—, (CF 3 )(CF 2 ) 5 CH 2 CH 2 O—, CHF 2 (CF 2 ) 3 CH 2 O—, or (CF 3 )(CF 2 ) 2 CH 2 O—.
11. The blood tubing of claim 1 , wherein said surface modifying macromolecule is described by formula:
wherein the [CH(CH 3 )CH 2 O] n unit has a theoretical molecular weight of from 500 to 2,000 Daltons.
12. The blood tubing of claim 11 , wherein the [CH(CH 3 )CH 2 O] n unit has Mw of 1000 g/mol.