Methods of killing bacteria and preventing or treating bacterial infection with oxidation products of safranal and methods of synthesizing safranal epoxides
A method of killing bacteria. The method includes contacting the bacteria with an effective amount of at least one oxidation product of safranal selected from the group consisting of a compound of formula II, a compound of formula III, and stereoisomers thereof. The oxidation products of safranal of formula II and/or formula III are preferably synthesized by subjecting safranal to oxidation reactions either photochemically with at least one peroxide in the presence of light or thermally with at least one organic peracid.
1. A method of synthesizing at least one safranal epoxide, comprising:
reacting safranal with at least one organic peracid at a temperature of 15-35° C. to thermally epoxidize the safranal to form the at least one safranal epoxide,
wherein the at least one safranal epoxide is at least one selected from the group consisting of a compound of formula II and a compound of formula III
2. The method of claim 1 , wherein the at least one safranal epoxide is the compound of formula II, and
wherein the method further comprises reacting the compound of formula II with at least one peroxide in the presence of light to photochemically epoxidize the compound of formula II to form the compound of formula III.