IP Library › Granted Patent US 9,708,334

Granted Patent B2

US 9,708,334 · App. 15/306,064 · Granted Jul 18, 2017

Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors

Inventors: Jillian Basinger (San Diego, CA); Brett Bookser (San Diego, CA); Mi Chen (San Diego, CA); DeMichael Chung (San Diego, CA); Varsha Gupta (Encinitas, CA); Andrew Hudson (San Diego, CA); Alan Kaplan (San Diego, CA); James Na (La Jolla, CA); Joel Renick (San Diego, CA); Vincent Santora (San Diego, CA)

Assignee: Dart NeuroScience (Cayman) Ltd.

C07D487/04 C07D471/04 C07D519/00

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Quick Facts

Patent No.: US 9,708,334
App. No.: 15/306,064
Granted: Jul 18, 2017
Kind: B2

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Abstract

The invention provides a chemical entity of Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and X have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alcohol-dependence.

Claims (628)

1. A compound of Formula I:

(I), or pharmaceutically acceptable salts thereof,

wherein

R 1 is selected from the group consisting of: —CO 2 H, —C(O)N(R a ) 2 , —SO 2 (C 1-4 alkyl), —SO 2 CH 2 (C 3-6 cycloalkyl), —CN,

where each R a is independently —H, or —C 1-3 alkyl;

R 2 is selected from the group consisting of: —H, halo, —C 1-3 alkyl, —C 1-3 haloalkyl, —C 1-3 alkoxy, and —CN;

R 3 is selected from the group consisting of:

(a) —H, —C 1-6 alkyl, —C 1-6 haloalkyl, —(C 1-3 alkyl) 0-1 C 3-6 cycloalkyl, or —(C 1-3 alkyl) 0-1 heterocycloalkyl;

(b) benzyl or phenyl, wherein the phenyl is unsubstituted or substituted with one to three members each independently selected from the group consisting of: halo, —C 1-4 alkyl, —C 1-4 haloalkyl, —C 1-6 alkoxy, and —CN; and

(c) monocyclic five or six membered heteroaryl ring containing one to three nitrogen members, unsubstituted or substituted with one to three members each independently selected from the group consisting of: —C 1-6 alkyl, —C 1-6 haloalkyl, —C 1-3 alkoxy, —C 1-3 haloalkoxy, —C 3-6 cycloalkyl, and —CN;

R 4 is selected from the group consisting of: —H, —F, —C 1-4 alkyl, —C 1-4 haloalkyl, —C 1-4 alkoxy, —OH, phenyl, and 4-trifluoromethylphenyl;

R 5 is selected from the group consisting of:

(a) —C 1-6 alkyl, —C 1-6 haloalkyl, —OC 1-6 alkyl or —OC 1-6 haloalkyl;

(b) —(C 1-3 alkyl) 0-1 C 3-6 cycloalkyl, —(C 1-3 alkyl) 0-1 heterocycloalkyl, —O(C 1-3 alkyl) 0-1 C 3-6 cycloalkyl, —O(C 1-3 alkyl) 0-1 heterocycloalkyl, or —O(C 1-3 haloalkyl) 0-1 C 3-6 cycloalkyl, wherein each cycloalkyl member is unsubstituted or substituted with one to three members independently selected from the group consisting of: -D, —F, —OC 1-3 alkyl, and —C 1-4 haloalkyl, wherein each heterocycloalkyl member is a four, five, or six membered monocyclic ring, unsubstituted or substituted with one to three members each independently —F, or —C 1-6 alkyl; and

(c) phenyl or pyridyl, each unsubstituted or substituted with one to three members each independently selected from the group consisting of: halo, —C 1-6 alkyl, and C 1-6 haloalkyl;

X is —(CR b ) 1-2 —; and

each R b is independently —H, or —C 1-3 alkyl.

2. The compound of claim 1 , wherein R 1 is —OCH 3 , —CO 2 H, —C(O)NH 2 , —C(O)NHCH 3 , —C(O)N(CH 3 ) 2 , —SO 2 CH 3 , —SO 2 CH 2 CH 3 , —SO 2 CH(CH 3 ) 2 , —SO 2 CH 2 cyclopropyl, —CN,

or oxazolidin-2-one, or

R 1 is —SO 2 (C 1-4 alkyl) or —CN, or R 1 is —SO 2 CH 3 or —CN.

3. The compound of claim 1 , R 2 is —H, —Cl, —F or —OCH 3 , or R 2 is —H, —OCH 3 or —Cl.

4. The compound of claim 1 , wherein R 3 is —H, —CH 3 , —CH(CH 3 ) 2 , —CH 2 CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 OCH 3 , (2S)-2-methylbutyl, —CH 2 CF 3 , —CH 2 CF(CH 3 ) 2 , (2,2-difluorocyclopropyl)methyl, 3,3-difluorocyclobutyl)methyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, 4,4-difluorocyclohexyl, oxan-4-yl, oxan-4-ylmethyl or oxolan-3-ylmethyl, or

R 3 is phenyl, benzyl or pyridyl unsubstituted or substituted with one to three members independently selected from the group consisting of: halo, —C 1-4 alkyl, —C 1-4 haloalkyl, —C 1-4 alkoxy, and —CN, or

R 3 is phenyl, benzyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-(trifluoromethyl)phenyl, 4-(trifluoromethyl)phenyl, 2,4-difluorophenyl, 2-methylphenyl, 3-methylphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-cyanophenyl, 2,4-difluoro-3-methylphenyl, 2,5-difluorophenyl, 3,4-difluorophenyl, 3-(difluoromethyl)-4-fluorophenyl, 2-chloro-3-fluorophenyl, 5-chloro-2-fluorophenyl, 3-chloro-2-fluorophenyl, 2-fluoro-3-(trifluoromethyl)phenyl, 2-fluoro-3-methylphenyl, or 2-fluoro-5-methylphenyl, or

R 3 is phenyl, 2-fluorophenyl, 4-fluorophenyl, 3-methylphenyl, 2,5-difluorophenyl, 2-fluoro-3-(trifluoromethyl)phenyl, 2-fluoro-3-methylphenyl, 2-cyclopropylpyridin-4-yl, 2-methylpyridin-4-yl, 2-ethylpyridin-4-yl, 5-fluoropyridin-3-yl, 5-methylpyridin-2-yl, or 5-fluoropyridin-2-yl, or

R 3 is 1,2-dimethyl-1H-imidazol-4-yl, 1-methyl-1H-imidazol-4-yl, 1-methyl-1H-pyrazol-3-yl, 1-methyl-1H-pyrazol-4-yl, 2-(propan-2-yloxy)pyridin-4-yl, 2-(trifluoromethyl)pyridin-4-yl, 2,6-dimethylpyridin-4-yl, 2-cyclobutylpyridin-4-yl, 2-cyclopropylpyridin-4-yl, 2-ethoxypyridin-4-yl, 2-ethylpyridin-4-yl, 2-methoxypyridin-4-yl, 2-methylpyridin-4-yl, 3,5-difluoropyridin-2-yl, 3-fluoropyridin-2-yl, 3-fluoropyridin-4-yl, 3-methylpyridin-2-yl, 4-methylpyridin-2-yl, 5-(trifluoromethyl)pyridin-2-yl, 5-chloropyridin-2-yl, 5-fluoro-2-methoxypyridin-3-yl, 5-fluoro-2-methylpyridin-3-yl, 5-fluoro-3-methylpyridin-2-yl, 5-fluoro-4-methylpyridin-2-yl, 5-fluoro-4-methylpyridin-3-yl, 5-fluoro-6-methoxypyridin-3-yl, 5-fluoro-6-methylpyridin-2-yl, 5-fluoro-6-methylpyridin-3-yl, 5-fluoropyridin-2-yl, 5-fluoropyridin-3-yl, 5-methylpyridin-2-yl, 6-(trifluoromethyl)pyridin-3-yl, 6-methoxypyridin-2-yl, 6-methylpyridin-2-yl, 6-methylpyridin-3-yl, pyridazin-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridine-2-carbonitrile, or trimethyl-1H-pyrazol-4-yl, or

R 3 is phenyl, 2-fluorophenyl, 4-fluorophenyl, 3-methylphenyl, 2,5-difluorophenyl, 2-fluoro-3-(trifluoromethyl)phenyl, 2-fluoro-3-methylphenyl, 2-cyclopropylpyridin-4-yl, or 2-ethylpyridin-4-yl.

5. The compound of claim 1 , wherein R 4 is —H, —CH 3 , —CF 3 , —C 1-3 alkoxy, phenyl, or 4-trifluoromethylphenyl, or R 4 is —H.

6. The compound of claim 1 , wherein R 5 is —CH 2 CH 2 (CH 3 ) 3 , —CF(CH 2 CH 3 ) 2 , —OCH 2 C(CH 3 ) 3 , —OCH(CH 3 ) 2 , —OCH(CH 2 CH 3 ) 2 , —OCH 2 CF 3 , —OCH 2 CHF 2 , —OCH(CH 3 )(CH 2 F), —OCH(CH 3 )(CHF 2 ), —OCH(CH 3 )(CF 3 ), [(2S)-1,1,1-trifluoropropan-2-yl]oxy, —OC(CH 3 ) 2 (CF 3 ), (3-methylbutan-2-yl)oxy, pentan-2-yloxy, —OCH 2 cyclopropyl, (1-methyl cyclopropyl)methoxy, 1-cyclopropylethoxy, 1-methylcyclopropoxy, cyclopentyloxy, (3-methyloxetan-3-yl)methoxy, oxetan-3-yloxy, or [1-(trifluoromethyl)cyclopropyl]methoxy, or

R 5 is —OCH(CH 3 ) 2 , —OCH 2 C(CH 3 ) 3 , —OCH(CH 3 )(CF 3 ), or [(2S)-1,1,1-trifluoropropan-2-yl]oxy, or

R 5 is cyclobutyl, cyclopentyl, 1-deuterocyclohexyl, 1-methoxycyclobutyl, 1-fluorocyclobutyl, 1-fluorocyclopentyl, or 1,4,4-trifluorocyclohexyl, or

R 5 is 3-fluorooxetan-3-yl, 4-fluorooxan-4-yl, azetidine, pyrrolidine, 3,3-difluoropyrrolidine, piperidine, 4,4-difluoropiperidin-1-yl, or morpholin-4-yl, or

R 5 is phenyl, 2-fluorophenyl, 3-fluorophenyl, 3-methylphenyl, 3-(trifluoromethyl)phenyl, 3,5-difluorophenyl, pyridine, 2-(trifluoromethyl)pyridine, or 5-fluoropyridin-3-yl, or

R 5 is —OCH(CH 3 ) 2 , —OCH 2 C(CH 3 ) 3 , —OCH(CH 3 )(CF 3 ), or [(2S)-1,1,1-trifluoropropan-2-yl]oxy, cyclopentyl or 3-fluorophenyl.

7. The compound of claim 1 , wherein X is —CH 2 CH 2 —, or CH 2 (CH 3 ) 2 —, or X is —CH 2 —.

8. The compound of claim 1 , wherein R 1 is —SO 2 (C 1-3 alkyl), or —CN, R 3 is phenyl, or pyridyl unsubstituted or substituted with one to three members independently selected from the group consisting of: halo, —C 1 - 4 alkyl, —C 1-4 haloalkyl, —C 1-4 alkoxy, and —CN, R 5 is —OCH(CH 3 ) 2 , —OCH 2 C(CH 3 ) 3 , —OCH(CH 3 )(CF 3 ), [(2S)-1,1,1-trifluoropropan-2-yl]oxy, cyclopentyl, 3,5-difluorophenyl, and 3-fluorophenyl, and X is —CH 2 —.

9. The compound of claim 1 having the structure of Formula (Ia):

or pharmaceutically acceptable salts thereof.

10. The compound of claim 1 having the structure of Formula (Ib):

or pharmaceutically acceptable salts thereof.

11. A compound selected from the group consisting of:

(2-(4-Fluorophenyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)(2-isopropoxy-5-(methylsulfonyl)phenyl)methanone;

(2-(3,4-Difluorophenyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)(2-isopropoxy-5-(methylsulfonyl)phenyl)methanone;

3-(2-(2-Methylpyridin-4-yl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)-4-(neopentyloxy)benzonitrile;

2-Chloro-3-(2-(4-fluorophenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)-4-((1,1,1-trifluoropropan-2-yl)oxy)benzoic acid;

4-(3-Fluorophenyl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-((1,1-Difluoropropan-2-yl)oxy)-3-(2-(4-fluorophenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)benzonitrile;

4-(3,3-Dimethylbutyl)-3-(2-(4-fluorophenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)-2-methoxybenzonitrile;

4-[(1 1-Difluoropropan-2-yl)oxy]-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy -4-(1 4 4-trifluorocyclohexyl)benzonitrile;

2-Chloro-3-[2-(2-methoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(1-Fluorocyclobutyl)-2-methoxy-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(4-Fluorooxan-4-yl)-2-methoxy-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

2-Chloro-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

4-(1-Fluorocyclobutyl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(4-Fluorooxan-4-yl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

4-(1-Fluorocyclobutyl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(4-Fluorooxan-4-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2 2 2-trifluoroethoxy)benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-(2-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Chloro-4-fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4-Fluoro-3-methylphenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3 4-Difluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-3-methylphenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-[3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2-[3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-[2-fluoro-3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-[3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-[5-methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2-[3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

4 4-Difluoro-1-(4-methanesulfonyl-2-{2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}phenyl)piperidine;

4-Difluoro-1-(4-methanesulfonyl-2-{2-[3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}phenyl)piperidine;

4 4-Difluoro-1-{2-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}piperidine;

2-(2-Fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluoro-3-methylphenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(5-Chloro-2-fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]Oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluoro-3-methylphenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(5-Chloro-2-fluorophenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluoro-3-methylphenyl)-5-[2-(2 2-dimethylpropoxy)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(5-Chloro-2-fluorophenyl)-5-[2-(2 2-dimethylpropoxy)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[5-methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluoro-3-methylphenyl)-5-[5-methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(5-Chloro-2-fluorophenyl)-5-[5-methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

4 4-Difluoro-1-{2-[2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}piperidine;

1-{2-[2-(2 4-Difluoro-3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}-4 4-difluoropiperidine;

1-{2-[2-(5-Chloro-2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}-4 4-difluoropiperidine;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[3-(Difluoromethyl)-4-fluorophenyl]-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[3-(Difluoromethyl)-4-fluorophenyl]-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[3-(Difluoromethyl)-4-fluorophenyl]-5-[2-(2 2-dimethylpropoxy)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-(2-fluoro-3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[3-(Difluoromethyl)-4-fluorophenyl]-5-[5-(ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2 4-Difluorophenyl)-5-[5-(ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[3-(Difluoromethyl)-4-fluorophenyl]-5-[5-(ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-3-methylphenyl)-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Methylphenyl)-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-Phenyl-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4-Fluorophenyl)-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3 4-Difluorophenyl)-5-[5-(propane-2-sulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-3-methylphenyl)-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Methylphenyl)-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-Phenyl-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4-Fluorophenyl)-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3 4-Difluorophenyl)-5-[2-(propan-2-yloxy)-5-(propane-2-sulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

4-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

5-[5-Methanesulfonyl-2-(2 2 2-trifluoroethoxy)benzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4-Fluorophenyl)-5-[5-methanesulfonyl-2-(2 2 2-trifluoroethoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[5-methanesulfonyl-2-(2 2 2-trifluoroethoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(2 2 2-trifluoroethoxy)benzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-3-methylphenyl)-5-[5-methanesulfonyl-2-(2 2 2-trifluoroethoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-Fluoro-2-{5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

3-Fluoro-5-{5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

4-{5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

4-Difluoro-1-{4-methanesulfonyl-2-[2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]phenyl}piperidine;

4-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

3-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

4-{5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

3-{5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

5-Fluoro-2-{5-[5-methanesulfonyl-2-(piperidin-1-yl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

3-Fluoro-5-{5-[5-methanesulfonyl-2-(piperidin-1-yl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

4-{5-[5-Methanesulfonyl-2-(piperidin-1-yl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

2-(2 5-Difluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-5-methylphenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

1-{2-[2-(2 5-Difluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}-4 4-difluoropiperidine;

4 4-Difluoro-1-{2-[2-(2-fluoro-5-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}piperidine;

2-(2 5-Difluorophenyl)-5-[5-(ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2-(2-fluoro-5-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

1-{2-[2-(2 5-Difluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(ethanesulfonyl)phenyl}-4 4-difluoropiperidine;

1-[4-(Ethanesulfonyl)-2-[2-(2-fluoro-5-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]phenyl]-4 4-difluoropiperidine;

2-(2 5-Difluorophenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-5-methylphenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

4-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-ethylpyridine;

4-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-ethylpyridine;

2-Ethyl-4-[5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine;

4-{5-[5-(Ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-ethylpyridine;

2-{5-[2-(4 4-Difluoropiperidin-1-yl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-(2-fluoro-5-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-(2 5-difluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-[2-fluoro-3-(trifluoromethyl)phenyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-(2-fluoro-3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

4-{5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

2-Ethyl-4-{5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

5-(5-Cyclopropylmethanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-(5-Cyclopropylmethanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Chloro-2-fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Chloro-3-fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Chloro-2-fluorophenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Chloro-3-fluorophenyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(3-Chloro-2-fluorophenyl)-5-[5-(ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Chloro-3-fluorophenyl)-5-[5-(ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-{5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-1-methyl-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-1-[3-(trifluoromethyl)phenyl]-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[1-(5-Fluoropyridin-2-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(pyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(pyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-{2-[6-(trifluoromethyl)pyridin-3-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-{2-[6-(trifluoromethyl)pyridin-3-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(1-Fluorocyclobutyl)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(4-Fluorooxan-4-yl)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(3-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(3-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(pyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(pyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(6-methylpyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(6-methylpyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(3-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(3-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(4-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(4-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(6-methoxypyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(6-methoxypyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(2-methoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(5-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(1-methyl-1H-pyrazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(1 2-Dimethyl-1H-imidazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(1 2-Dimethyl-1H-imidazol-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(1 2-dimethyl-1H-imidazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(4-Cyanophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(4-Cyanophenyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-{2-[5-(trifluoromethyl)pyridin-2-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-{2-[5-(trifluoromethyl)pyridin-2-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2R)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(1-methyl-1H-pyrazol-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(1-methyl-1H-imidazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(1-methyl-1H-pyrazol-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[1-(1-methyl-1H-imidazol-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(5-fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(5-Fluoro-6-methylpyridin-2-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(5-fluoro-3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-(4-Fluorophenyl)-5-(3-methanesulfonyl-2-methoxy-6-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-Fluoro-2-[5-(3-methanesulfonyl-2-methoxy-6-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine;

5-Fluoro-2-(5-{5-methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl)pyridine;

2-(4-Fluorophenyl)-5-{5-methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-Chloro-3-[2-(5-fluoro-4-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-4-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}-3-[2-(trimethyl-1H-pyrazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

2-Chloro-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}-3-[2-(trimethyl-1H-pyrazol-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

2-Methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

2-Methoxy-3-[1-(2-methyl pyridin-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[1-(2-methylpyridin-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(3-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(5-Fluoro-2-methoxypyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(5-fluoro-2-methoxypyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(5-Fluoro-6-methoxypyridin-3-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-6-methoxypyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(2 2-Dimethylpropoxy)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(2 2-Dimethylpropoxy)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

2-Methoxy-3-{2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-{2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(propan-2-yloxy)benzonitrile;

2-Methoxy-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

2-Chloro-3-{2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

4-(2 2-Difluoroethoxy)-2-methoxy-3-{2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}benzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(2 2-Difluoroethoxy)-2-methoxy-3-[2-(6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(2 2-Difluoroethoxy)-2-methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-{2-Phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(6-Methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

2-(4-Fluorophenyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(6-Methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-3-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(4-Methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-4-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(Pyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

5-(2-Cyclopentyl-5-methanesulfonylbenzoyl)-2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(5-Fluoro-6-methylpyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-4-methylpyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(5-Fluoro-2-methylpyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

4-[5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-2-methylpyridine;

2-[5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-4-methylpyridine;

3-Fluoro-5-[5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine;

5-Fluoro-2-[5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-4-methylpyridine;

2-[5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-6-methylpyridine;

5-Fluoro-2-[5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-3-methylpyridine;

3-Fluoro-6-[5-(5-methane sulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]-2-methylpyridine;

1-{2-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}piperidine;

3-[2-(2-Methoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(2-Methoxypyridin-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(2-Methoxypyridin-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Methoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Ethoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Ethoxypyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-{2-[2-(Propan-2-yloxy)pyridin-4-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(Propan-2-yloxy)-3-{2-[2-(propan-2-yloxy)pyridin-4-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}benzonitrile;

3-{2-[2-(Propan-2-yl)pyridin-4-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-(propan-2-yloxy)benzonitrile;

3-{2-[2-(Propan-2-yl)pyridin-4-yl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(1-Fluorocyclopentyl)-2-methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(1-Fluorocyclopentyl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(2-Fluoro-2-methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(2-Fluoro-2-methylpropyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2 6-Dimethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2 6-Dimethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-{2-Benzyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-{1-Benzyl-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(Propan-2-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(Propan-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(2-Methylpropyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-{1-Cyclopentyl-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-{2-Cyclopentyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2 4-Difluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2 4-Difluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(3-Methoxypropyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(3-Methoxypropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(Oxan-4-ylmethyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Fluoro-3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(Oxan-4-ylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Benzyl-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-(5-Methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2-(2-methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-Methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2-(2-methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Cyclobutylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-{2-Cyclohexyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Cyclohexyl-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(2-Cyclopropylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Cyclopropylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

2-Cyclopentyl-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-Cyclopentyl-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Oxan-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

2-(Cyclobutylmethyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]Oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(Cyclobutylmethyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Cyclobutylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(Oxan-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-(Cyclopentylmethyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Cyclopentylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Cyclopentyl-5-[5-(ethanesulfonyl)-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{2-[(2S)-2-Methylbutyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-(propan-2-yloxy)benzonitrile;

2-Cyclopentyl-5-[5-(ethanesulfonyl)-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{2-[(2S)-2-Methylbutyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(Oxolan-3-ylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(Oxolan-3-ylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[1-(Pyridazin-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(Propan-2-yloxy)-3-[2-(pyridazin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(Pyridazin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-(2-{Imidazo[1 2-c]pyridin-7-yl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl)-4-(propan-2-yloxy)benzonitrile;

3-(2-{Imidazo[1 2-c]pyridin-7-yl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl)-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-(Cyclobutylmethyl)-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2-(2-methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

1-{2-[2-(Cyclobutylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(ethanesulfonyl)phenyl}-4 4-difluoropiperidine;

4 4-Difluoro-1-(4-methane sulfonyl-2-{2-[(2S)-2-methylbutyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}phenyl)piperidine;

1-(2-{2-Cyclopentyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-methanesulfonylphenyl)-4 4-difluoropiperidine;

1-{2-[2-(Cyclobutylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}-4 4-difluoropiperidine;

4-Difluoro-1-{4-methanesulfonyl-2-[2-(2-methylpropyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]phenyl}piperidine;

4 4-Difluoro-1-{4-methanesulfonyl-2-[2-(propan-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]phenyl}piperidine;

2-(2-Fluoro-2-methylpropyl)-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-{5-Methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2-phenyl-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-{5-Methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2-(3-methylphenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[2-Fluoro-3-(trifluoromethyl)phenyl]-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(5-Chloro-2-fluorophenyl)-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4-Fluorophenyl)-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-3-methylphenyl)-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluoro-5-methylphenyl)-5-{5-methanesulfonyl-2-[(3-methyloxetan-3-yl)methoxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Pyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(Propan-2-yloxy)-3-[1-(2 2 2-trifluoroethyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-1-(2 2 2-trifluoroethyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

1-{Imidazo[1 2-a]pyridin-5-yl}-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

4-(Propan-2-yloxy)-3-[2-(pyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

5-[2-(3-Fluorophenyl)-5-methanesulfonylbenzoyl]-2-(oxan-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(Cyclopropylmethyl)-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(Cyclopropylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(Cyclopropylmethyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

1-(Cyclopropylmethyl)-5-[2-(3-fluorophenyl)-5- methanesulfonylbenzoy]-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[(2 2-Difluorocyclopropyl)methyl]-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4 H 5 H 6H-pyrrolo[3,4-c]pyrazole;

1-[(2 2-Difluorocyclopropyl)methyl]-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[(2 2-Difluorocyclopropyl)methyl]-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]Oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{2-[(2 2-Difluorocyclopropyl)methyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-(propan-2-yloxy)benzonitrile;

3-{2-[(2 2-Difluorocyclopropyl)methyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[1-(Oxan-4-yl)-1H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(2-Cyclobutylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(2-Cyclobutylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-[(3 3-Difluorocyclobutyl)methyl]-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-{2-[(3 3-Difluorocyclobutyl)methyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl-}4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-[(3 3-Difluorocyclobutyl)methyl]-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-[(3 3-Difluorocyclobutyl)methyl]-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

5-[5-(5-Cyano-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine-2-carbonitrile;

5-{5-[5-Cyano-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine-2-carbonitrile;

4-[5-(5-Cyano-2-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine-2-carbonitrile;

4-{5-[5-Cyano-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine-2-carbonitrile;

2-(4 4-Difluorocyclohexyl)-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4 4-Difluorocyclohexyl)-5-[5-methanesulfonyl-2-(propan-2-yloxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(4 4-Difluorocyclohexyl)-5-(5-methanesulfonyl-2-{[(2S)-1 1 1-trifluoropropan-2-yl]Oxy}benzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-[2-(4 4-Difluorocyclohexyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-(4-Fluorophenyl)-5-{5-methanesulfonyl-2-[(1 1 1-trifluoro-2-methylpropan-2-yl)oxy]benzoyl}-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

4-Cyclopentyl-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-Cyclopentyl-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(4 4-Difluoropiperidin-1-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(2 2-Dimethylpropoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(1-methylcyclopropyl)methoxy]benzonitrile;

4-(Cyclopentyloxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

4-(3 3-Difluoropyrrolidin-1-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(propan-2-yloxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoro-2-methylpropan-2-yl)oxy]benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1-fluoropropan-2-yl)oxy]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(pentan-3-yloxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(oxetan-3-yloxy)benzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(pentan-2-yloxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2-methylpropoxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(3-methylbutan-2-yl)oxy]benzonitrile;

4-(1-Cyclopropylethoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(1-methylcyclopropoxy)benzonitrile;

4-(2 2-Dimethylpropoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(propan-2-yloxy)benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1 1 1-trifluoro-2-methylpropan-2-yl)oxy]benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(2 2 2-trifluoroethoxy)benzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(5-fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(propan-2-yloxy)benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-[(3-methyloxetan-3-yl)methoxy]benzonitrile;

3-[2-(5-Fluoro-6-methylpyridin-2-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-2-methoxy-4-(oxetan-3-yloxy)benzonitrile;

4-[(3-Methyloxetan-3-yl)methoxy]-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(2-Methyl pyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(4 4-Difluoropiperidin-1-yl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(2-Methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[(1 1 1-trifluoro-2-methylpropan-2-yl)oxy]benzonitrile;

3-[2-(2-Ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

4-(Cyclopropylmethoxy)-3-[2-(2-ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(2 2-Difluoroethoxy)-3-[2-(2-ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(4 4-Difluoropiperidin-1-yl)-3-[2-(2-ethylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

5-{2-[2-(2-Fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}-2-(trifluoromethyl)pyridine;

5-Fluoro-2-{5-[2-(5-fluoropyridin-3-yl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

5-Fluoro-2-{5-[5-methanesulfonyl-2-(5-methylpyridin-3-yl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}pyridine;

4-(2-Fluorophenyl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(3-Fluorophenyl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(5-Fluoropyridin-3-yl)-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-(pyridin-3-yl)benzonitrile;

4-(2-Fluorophenyl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

(2-(2-Fluorophenyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)(5-(methylsulfonyl)-2-(pyridin-3-yl)phenyl)methanone;

4-(5-Fluoropyridin-3-yl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(3-Fluorophenyl)-3-[2-(oxan-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

4-(3-Methylphenyl)-3-[2-(oxan-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

2-(2-Fluorophenyl)-5-[2-(2-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

2-(2-Fluorophenyl)-5-[2-(3-fluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole;

3-Fluoro-5-{2-[2-(2-fluorophenyl)-2H 4H 5H 6H-pyrrolo[3,4-e]pyrazole-5-carbonyl]-4-methanesulfonylphenyl}pyridine;

4-(3 5-Difluorophenyl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-{5-[2-(3 5-Difluorophenyl)-5-methanesulfonylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

4-(3-Methylphenyl)-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]benzonitrile;

3-[2-(2-Methylpyridin-4-yl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole-5-carbonyl]-4-[3-(trifluoromethyl)phenyl]benzonitrile;

5-Fluoro-2-[5-(5-methane sulfonyl-2-phenylbenzoyl)-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl]pyridine;

4-{5-[5-(Ethanesulfonyl)-2-phenylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol -2-yl}-2-methylpyridine;

4-{5-[5-(Ethanesulfonyl)-2-(3-fluorophenyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

4-{5-[2-(3 5-Difluorophenyl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-2-methylpyridine;

3-{5-[5-(Ethanesulfonyl)-2-phenylbenzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

3-{5-[5-(Ethanesulfonyl)-2-(3-fluorophenyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-y}-5-fluoropyridine;

3-{5-[2-(3 5-Difluorophenyl)-5-(ethanesulfonyl)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazol-2-yl}-5-fluoropyridine;

2-(4-Fluorophenyl)-5-[5-methanesulfonyl-2-(2-methylpropoxy)benzoyl]-2H 4H 5H 6H-pyrrolo[3,4-c]pyrazole; and pharmaceutically acceptable salts thereof.

12. A compound selected from the group consisting of:

3-(2-(4-Fluorophenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-2-methoxy-4-((1,1,1-trifluoropropan-2-yl)oxy)benzonitrile;

1-{2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}azetidine;

3-(2-(4-Fluorophenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-4-((1,1,1-trifluoropropan-2-yl)oxy)benzamide;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-(1 4 4-trifluorocyclohexyl)benzonitrile;

2-Methoxy-3-[2-(pyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-(1 4 4-trifluorocyclohexyl)benzonitrile;

4-(4-Fluorooxan-4-yl)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(5-Fluoropyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(pyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

2-Methoxy-3-[2-(pyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-1-methyl-1H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-1-[3-(trifluoromethyl)phenyl]-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-1-methyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-1-[3-(trifluoromethyl)phenyl]-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-1-phenyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

1-{4-Methanesulfonyl-2-[1-phenyl-3-(trifluoromethyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]phenyl}piperidine;

1-(4-Methanesulfonyl-2-{3-methyl-1-phenyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}phenyl)piperidine;

1-(4-Methanesulfonyl-2-{3-methyl-2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}phenyl)piperidine;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-1-phenyl-3-(trifluoromethyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

4-Cyclopentyl-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}benzonitrile;

5-(2-Cyclopentyl-5-methanesulfonylbenzoyl)-2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

3-(4-Cyclopentyl-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}phenyl)-1 3-oxazolidin-2-one;

3-(3-{2-Phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]phenyl)-1 3-oxazolidin-2-one;

4-[(1- 2 H)Cyclopentyl]-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}benzonitrile;

4-Cyclobutyl-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}benzonitrile;

4-Cyclopentyl-2-fluoro-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}benzonitrile;

2-Methoxy-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Fluoro-4-(3-fluorooxetan-3-yl)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-3-[1-(2 4-difluorophenyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

4-Cyclobutyl-2-fluoro-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[1-methyl-3-(trifluoromethyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-{1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[3-ethoxy-2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[1-(4-fluorophenyl)-7 7-dimethyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-methyl-3-(trifluoromethyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Fluoro-4-(1-fluorocyclopentyl)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Fluoro-4-(1-fluorocyclopentyl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-3-methyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[1-(4-fluorophenyl)-3-methyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-7 7-dimethyl-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(4-Fluorophenyl)-7 7-dimethyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(2 4-Difluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-{1-Benzyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-2-chloro-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

2-Chloro-3-[2-(4-fluorophenyl)-3-hydroxy-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-(4-Fluorophenyl)-5-{3-methanesulfonyl-2-methoxy-6-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

2-Fluoro-4-(4-fluorooxan-4-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-N N-dimethyl-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-{2-methyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-{2-methyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(3-methoxyphenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(4-methoxyphenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[2-(4-methoxyphenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

4-(3-Fluoropentan-3-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

3-[1-(5-Fluoropyridin-2-yl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[1-(5-fluoropyridin-2-yl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(pyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

4-(1-Fluorocyclobutyl)-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

2-Methoxy-3-[2-(pyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-{1-cyclohexyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-{1-Cyclohexyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(pyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[2-(pyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[1-(pyridin-3-yl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(pyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[2-(pyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[1-(oxan-4-yl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

2-Chloro-3-[2-(5-fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-(2 2 2-trifluoroethoxy)benzonitrile;

3-[2-(5-Fluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[2-(2-methylpyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-chloropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(5-Chloropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(5-fluoro-2-methoxypyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(5-Fluoro-2-methoxypyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-3-[2-(3 5-difluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(3 5-Difluoropyridin-2-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Methoxy-3-[2-(pyridin-3-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-{2-[6-(trifluoromethyl)pyridin-3-yl]-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-{2-[6-(trifluoromethyl)pyridin-3-yl]-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-{2-[2-(trifluoromethyl)pyridin-4-yl]-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-2-[2-(trifluoromethyl)pyridin-4-yl]-2H 4H 5H 6H 7H-pyrazolo[4, 3-c]pyridine-5-carbonyl-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-[2-(3-fluoropyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(3-Fluoropyridin-4-yl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Chloro-3-{3-[4-(trifluoromethyl)phenyl]-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

2-Methoxy-3-{3-[4-(trifluoromethyl)phenyl]-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}-4-{[(2S)-1 1 1-trifluoropropan-2-yl]oxy}benzonitrile;

3-[2-(4-Fluorophenyl)-3-methyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[1-(4-Fluorophenyl)-7 7-dimethyl-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1-methylcyclopropyl)methoxy]benzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-{[1-(trifluoromethyl)cyclopropyl]methoxy}benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-N-methyl-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

1-{3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}azetidine;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-N-methyl-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

1-{3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}azetidine;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-N-methyl-4-[1 1 1-trifluoropropan-2-yl)oxy]benzamide;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzamide;

4-Cyclopentyl-2-methoxy-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

4-Cyclopentyl-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

4-(3-Fluorooxetan-3-yl)-2-methoxy-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

4-Cyclobutyl-2-methoxy-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

4-(1-Fluorocyclobutyl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

4-(1-Fluorocyclopentyl)-2-methoxy-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

4-(1-Fluorocyclopentyl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

4-(4-Fluorooxan-4-yl)-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxybenzonitrile;

3-[2-(4-Fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-(1-methoxycyclobutyl)benzonitrile;

3 3-Difluoro-1-(4-methanesulfonyl-2-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}phenyl)pyrrolidine;

5-[2-(2 2-Dimethylpropoxy)-5-methanesulfonylbenzoyl]-2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

1-(4-Methanesulfonyl-2-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}phenyl)pyrrolidine;

1-(4-Methanesulfonyl-2-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}phenyl)azetidine;

5-[2-(Cyclopropylmethoxy)-5-methanesulfonylbenzoyl]-2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

2-Chloro-3-[1-(4-fluorophenyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

2-Chloro-4-(4 4-difluoropiperidin-1-yl)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-4-(2 2-dimethylpropoxy)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-4-(cyclopropylmethoxy)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-4-(morpholin-4-yl)-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-4-[(3-methyloxetan-3-yl)methoxy]-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-4-[(1-methylcyclopropyl)methoxy]-3-{2-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl}benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-[(1-methylcyclopropyl)methoxy]benzonitrile;

2-Chloro-3-[2-(4-fluorophenyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-4-{[1-(trifluoromethyl)cyclopropyl]methoxy}benzonitrile;

5-{5-Methanesulfonyl-2-[(1 1 1-trifluoropropan-2-yl)oxy]benzoyl}-3-phenyl-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine;

3-[1-(2 4-Difluorophenyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[2-(4-Fluorophenyl)-3-(trifluoromethyl)-2H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile;

3-[1-(4-Fluorophenyl)-3-(trifluoromethyl)-1H 4H 5H 6H 7H-pyrazolo[4,3-c]pyridine-5-carbonyl]-2-methoxy-4-[(1 1 1-trifluoropropan-2-yl)oxy]benzonitrile; and pharmaceutically acceptable salts thereof.

13. A pharmaceutical composition comprising: a pharmaceutically acceptable excipient; and an effective amount of at least one compound of claim 1 .

14. A pharmaceutical composition comprising: a pharmaceutically acceptable excipient; and an effective amount of at least one compound of claim 9 .

15. A pharmaceutical composition comprising: a pharmaceutically acceptable excipient; and an effective amount of at least one compound of claim 10 .

16. A pharmaceutical composition comprising: a pharmaceutically acceptable excipient; and an effective amount of at least one compound of claim 11 .

17. A pharmaceutical composition comprising: a pharmaceutically acceptable excipient; and an effective amount of at least one compound of claim 12 .

18. A method of treating a neurological disorder, comprising administering to a subject in need thereof an effective amount of at least one compound of claim 1 ,

wherein the neurological disorder is selected from the group consisting of: a central nervous system (CNS) disorder, a developmental disorder; a schizophrenia spectrum or psychotic disorder; a depressive disorder; an anxiety disorder; an obsessive-compulsive disorder; a dissociative disorder; a disruptive, impulse-control, or conduct disorder; a trauma- or stressor-related disorder; a feeding or eating disorder; a sleep-wake disorder; a sexual disorder; a substance-related or addictive disorder; and a personality disorder.

19. A method of treating a neurological disorder, comprising administering to a subject in need thereof an effective amount of at least one compound of claim 1 , wherein the neurological disorder is an acquired disorder selected from the group consisting of delirium, dementia, an age-associated cognitive deficit, a trauma-dependent loss of function, and a cognitive impairment due to chemotherapy.

20. A method of treating pain or alcohol-dependence, comprising administering to a subject in need thereof an effective amount of at least one compound of claim 1 .

Assignments (3)

MERGER Recorded Dec 2, 2021

From: DART NEUROSCIENCE (CAYMAN) LTD.

To: DART NEUROSCIENCE LLC

Reel/Frame 058275/0272 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2017

From: BASINGER, JILLIAN; BOOKSER, BRETT; CHEN, MI; CHUNG, DEMICHAEL; GUPTA, VARSHA; HUDSON, ANDREW; KAPLAN, ALAN; NA, JAMES; RENICK, JOEL; SANTORA, VINCENT

To: DART NEUROSCIENCE, LLC

Reel/Frame 042441/0977 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2017

From: DART NEUROSCIENCE, LLC

To: DART NEUROSCIENCE (CAYMAN) LTD.

Reel/Frame 042442/0022 →

Continuity (2)

Provisional Application 61983821 · Apr 24, 2014

Related Publication 20170044167A1 · Feb 16, 2017