Use of inhibitory peptides for the treatment of inflammatory diseases
An isolated peptide is disclosed which comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV), the isolated peptide comprising a nuclear targeting activity, the peptide being no longer than 20 amino acids.
1. A peptide comprising an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV), the peptide being capable of preventing P38α nuclear translocation, the peptide being no longer than 20 amino acids, the peptide being lipidated.
2. The peptide of claim 1 , comprising the sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 8.
3. The peptide of claim 1 , wherein a heterologous substance is linked to said amino acid sequence via a linker.
4. The peptide of claim 1 , comprising the amino acid sequence as selected from the group consisting of SEQ ID NO: 2 (PERYQNLSPVG), SEQ ID NO: 3 (PERYQNLSPVGS), SEQ ID NO: 4 (PERYQNLSPVGSG) and SEQ ID NO: 5 (PERYQNLSPVGSGA), SEQ ID NO: 6 (KPERYQNLSPVGSGA) and SEQ ID NO: 7 (KPERYQNLSPVAAAA).
5. The peptide of claim 1 , being myristoylated.
6. A method of treating a disorder selected from the group consisting of an inflammatory disorder, cancer and an immune disorder in a subject, the method comprising administering to the subject a therapeutically effective amount of a peptide into the subject, wherein the peptide comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV), the peptide being capable of preventing P38α nuclear translocation, the peptide being no longer than 20 amino acids, thereby treating the inflammatory disorder, cancer or immune disorder.
7. The method of claim 6 , wherein the immune disorder is an autoimmune disorder.
8. The method of claim 6 , wherein the inflammatory disorder is colitis.
9. A composition of matter comprising the peptide of claim 1 and a heterologous substance linked to said amino acid sequence via a linker.
10. A pharmaceutical composition comprising as an active agent the peptide of claim 1 and a pharmaceutically acceptable carrier.