Modulating nerves within bone using bone fasteners
Methods of using hardware (e.g., bone screws, anchors or other devices) previously inserted within the body to facilitate energy delivery are disclosed. The energy delivery (e.g., thermal energy) may be used for neuromodulation (such as stimulation or denervation), tissue heating and ablation, curing, and other applications in the spine and non-spine orthopedic locations.
1. A method of treating back pain in a subject having a pedicle screw inserted within a cancellous bone region of a vertebral body, the method comprising:
identifying a pedicle screw proximate a region of interest,
wherein the pedicle screw comprises a conductive material,
wherein at least a portion of the pedicle screw is in contact with a cancellous bone region of a vertebral body,
wherein said region of interest comprises a nerve within the cancellous bone region,
applying thermal energy to the pedicle screw to conduct heat to the cancellous bone region sufficient to ablate the nerve within the cancellous bone region.
2. The method of claim 1 , wherein the temperature of the thermal energy is between about 75 degrees Celsius and about 100 degrees Celsius.
3. The method of claim 1 , wherein the thermal energy is applied for a period of about 10 to about 30 minutes.
4. The method of claim 1 , wherein the applied thermal energy is sufficient to permanently treat back pain associated with the nerve.
5. The method of claim 1 , wherein the applied thermal energy is applied using a heat source.
6. The method of claim 1 , wherein the thermal energy is applied using a radio-frequency generator.
7. The method of claim 1 , wherein the thermal energy is applied for a period of 10 seconds to 1 hour.
8. A method of claim 1 , wherein the temperature of the thermal energy is between 70 degrees Celsius and 115 degrees Celsius.
9. The method of treating back pain of a subject, the method comprising:
performing a spinal fusion procedure between two adjacent vertebral bodies;
inserting a distal end of a first pedicle screw within a cancellous bone region of a first vertebral body of the two adjacent vertebral bodies; and
applying thermal energy to the first pedicle screw to conduct heat to the cancellous bone region sufficient to ablate a nerve within the cancellous bone region of the first vertebral body.
10. The method of claim 9 , further comprising inserting a distal end of a second pedicle screw within the cancellous bone region of the first vertebral body applying thermal energy to the second pedicle screw to conduct heat to the cancellous bone region of the first vertebral body sufficient to ablate the nerve within the cancellous bone region of the first vertebral body in combination with the applied thermal energy to the first pedicle screw.
11. The method of claim 10 , wherein the thermal energy is applied to the first pedicle screw and the second pedicle screw simultaneously.
12. The method of claim 9 , further comprising inserting a distal end of a second pedicle screw within a cancellous bone region of a second vertebral body of the two adjacent vertebral bodies and applying thermal energy to the second pedicle screw to conduct heat to the cancellous bone region of the second vertebral body sufficient to ablate a nerve within the cancellous bone region of the second vertebral body.
13. The method of claim 12 , wherein the thermal energy is applied to the first pedicle screw and the second pedicle screw simultaneously.
14. The method of claim 12 , wherein the thermal energy is applied to the first pedicle screw and the second pedicle screw successively.