Self-referencing optical measurement for breast cancer detection
View Patent ↗Optical data is obtained from a pair of breasts, employing a simultaneous bilateral referencing protocol, and is subsequently analyzed employing a self-referencing data analysis method. Optical measurements can be performed on both breasts simultaneously under various protocols, including resting-state measures and evoked responses. Sensing hardware and data collection protocols are economical and can be implemented without patient discomfort. The natural variance inherently associated with optical measures of the breast is reduced by: imposition of substantially symmetric boundary conditions; collection of simultaneous bilateral dynamic measures; referencing measurement data of one breast to measurement data from another.
1. A system for detecting features within a pair of breasts, said system comprising:
a diffuse optical measurement system including at least one pair of optical sources and a pair of sensing heads configured to fit a pair of breasts and to simultaneously measure optical tomographical data from said pair of breasts while imposing bilaterally symmetric external boundary conditions for optical tomography upon said pair of breasts to form simultaneously measured optical tomographical data; and
a computer configured to analyze said simultaneously measured optical tomographical data by running an automated program, wherein said automated program comprises steps of:
generating a reference data field as a function of space and measurement time based on a first subset of said simultaneously measured optical tomographical data on one of said pair of breasts;
performing a statistical analysis on a variation, from said reference data field, of a data field including said simultaneously measured tomographical data for another of said pair of breasts wherein a spatial standard deviation of the temporal mean (SSDTM) is obtained for a first breast and a second breast of the pair of breasts; and
generating data that is indicative of a presence or absence of breast cancer in said another of said pair of breasts based on said statistical analysis, wherein the spatial standard deviation of the temporal mean (SSDTM) for the first breast is subtracted from the spatial standard deviation of the temporal mean (SSDTM) of the second breast to determine a paired difference value, wherein the presence of breast cancer is indicated by the paired difference value being above a threshold.
2. The system of claim 1 , wherein said variation is measured for each pair of corresponding physical points that are present in said pair of breasts and are mapped to each other by a mirror symmetry in said bilaterally symmetric external boundary conditions.
3. The system of claim 2 , wherein said statistical analysis includes an outlier analysis that identifies locations of physical points at which an absolute value of said variation is greater than a predefined multiple of a standard deviation of said variation.
4. The system of claim 1 , wherein said generating of said reference data field comprises spatially averaging said simultaneously measured optical tomographical data or derived data therefrom across said pair of breasts.
5. The system of claim 1 , wherein said generating of said reference data field as said function of space and measurement time is performed employing said simultaneously measured optical tomographical data, without employing data generated from any other physical breast than said pair of breasts or from any model for a physical breast.
6. The system of claim 1 , wherein said pair of sensing heads is configured to provide a bilaterally symmetric articulation while measuring said optical tomographical data, wherein said pair of sensing heads maintain said mirror symmetry.
7. The system of claim 1 , wherein said simultaneously measured optical tomographical data comprises data on hemodynamic response or vascular tone.
8. The system of claim 1 , wherein said simultaneously measured optical tomographical data comprises an oxyhemoglobin level and a deoxyhemoglobin level.
9. The system of claim 8 , wherein said reference data field comprises at least one of:
a total hemoglobin level;
a hemoglobin oxygen saturation; and
a measure of hemoglobin oxygen extraction efficiency.
10. The system of claim 1 , wherein said system further comprises a means for altering a composition of a respiratory gas supplied to a patient from whom said optical tomographical data is simultaneously measured.
11. A method of detecting features within a pair of breasts comprising:
mounting at least one pair of optical sources and a pair of sensing heads of a diffuse optical measurement system to fit a pair of breasts of a patient;
simultaneously measuring optical tomographical data from said pair of breasts while imposing bilaterally symmetric external boundary conditions for optical tomography upon said pair of breasts to form simultaneously measured optical tomographical data;
analyzing said simultaneously measured optical tomographical data by running an automated program on a computing means, wherein said automated program comprises steps of:
generating a reference data field as a function of space and measurement time based on a first subset of said simultaneously measured optical tomographical data on one of said pair of breasts;
performing a statistical analysis on a variation, from said reference data field, of a data field including said simultaneously measured tomographical data for another of said pair of breasts, wherein a spatial standard deviation of the temporal mean (SSDTM) is obtained for a first breast and a second breast of the pair of breasts; and
generating data that is indicative of a presence or absence of breast cancer in said another of said pair of breasts based on said statistical analysis, wherein the spatial standard deviation of the temporal mean (SSDTM) for the first breast is subtracted from the spatial standard deviation of the temporal mean (SSDTM) of the second breast to determine a paired difference value, wherein the presence of breast cancer is indicated by the paired difference value being above a threshold.
12. The method of claim 11 , wherein said variation is measured for each pair of corresponding physical points that are present in said pair of breasts and are mapped to each other by a mirror symmetry in said bilaterally symmetric external boundary conditions.
13. The method of claim 12 , wherein said statistical analysis includes an outlier analysis that identifies locations of physical points at which an absolute value of said variation is greater than a predefined multiple of a standard deviation of said variation.
14. The method of claim 11 , wherein said generating of said reference data field comprises spatially averaging said simultaneously measured optical tomographical data or derived data therefrom across said pair of breasts.
15. The method of claim 11 , wherein said generating of said reference data field as said function of space and measurement time is performed employing said simultaneously measured optical tomographical data, without employing data generated from any other physical breast than said pair of breasts or from any model for a physical breast.
16. The method of claim 11 , further comprising providing a bilaterally symmetric articulation while measuring said optical tomographical data, wherein said pair of sensing heads maintain said mirror symmetry.
17. The method of claim 11 , wherein said simultaneously measured optical tomographical data comprises data on hemodynamic response or vascular tone.
18. The method of claim 11 , wherein said optical tomographical data is measured under a condition of a resting state.
19. The method of claim 11 , wherein said optical tomographical data is measured after inducing an evoked change in cardiovascular tone or cardiovascular functionality of said patient.
20. The method of claim 11 , further comprising altering a composition of a respiratory gas supplied to a patient from whom said optical tomographical data is simultaneously measured.