CEACAM1 mediated protective immunity
The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the supression of immune responses in a targeted fashion, by increasing the functional concentration of the CEACAM1 protein in a target tissue to create a localized protective immunity for the treatment of autoimmune diseases and diseases requiring the transplantation of tissue.
1. A method for inducing a protective immunity from the activity of activated Natural Killer cells in a target tissue to be transplanted, wherein said method comprises the induction of CEACAM1 protein production in said target tissue to be transplanted by transforming said target tissue to be transplanted with a nucleic acid encoding CEACAM1 protein by particle mediated transfer of an expression vector containing said nucleic acid, and wherein said Natural Killer cells express CEACAM1.