Compounds useful as modulators of TRPM8
The present disclosure relates to compounds which are useful as cooling sensation compounds.
1. A compound selected from the group consisting of
or a salt thereof.
2. The compound of claim 1 having the structure
or a salt thereof.
3. The compound of claim 1 having the structure
or a salt thereof.
4. The compound of claim 1 having the structure
or a salt thereof.
5. The compound of claim 1 having the structure
or a salt thereof.
6. The compound of claim 1 having the structure
or a salt thereof.
7. A composition, comprising a compound of claim 1 and at least one carrier.
8. The composition of claim 7 , wherein the composition is an ingestible composition or personal care product.
9. The composition of claim 7 , wherein the composition is a food or beverage.
10. The composition of claim 7 , wherein the composition is a topical personal care product.
11. The composition of claim 7 , wherein the composition is in form of a solid, semi-solid, plaster, solution, suspension, lotion, cream, foam, gel, paste, or emulsion.
12. The composition of claim 7 , wherein the compound in the composition is in a concentration ranging from about 0.0001 ppm to 100,000 ppm.
13. The composition of claim 7 , wherein the compound in the composition is in a concentration ranging from about 1 ppm to 500 ppm.
14. The composition of claim 7 , which is a textile product or a packaging material.
15. A method of modulating transient receptor potential channel melastatin member 8 (TRPM8) comprising contacting the receptor with a compound of claim 1 .
16. The method of claim 15 , wherein the compound is a TRPM8 receptor agonist.
17. A method of modulating the cooling sensation of a composition comprising combining the composition with a compound of claim 1 to form a modified composition.
18. A method of inducing a cooling sensation in a human or animal comprising contacting the human or animal with a compound of claim 1 .