Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux
View Patent ↗One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or preventive therapy. This method involves administering a composition containing a therapeutically effective amount of a ROS inhibitor to a subject in need thereof.
1. A method of treating diminished ischemia-induced neovascularization in a diabetic subject consisting of:
a) measuring diminished ischemia-induced neovascularization in a diabetic subject: and
b) transdermally administering to the diabetic subject a pharmaceutical composition consisting of deferoxamine in a sterile diluent or consisting of deferoxamine in solution with a pharmaceutically acceptable salt, liquid carrier, excipient, or stabilizer, in an amount effective to increase neovascularization.
2. The method of claim 1 , wherein said deferoxamine is in a solution with a liquid glycol carrier.
3. The method of claim 1 , wherein said deferoxamine is in sterile saline.