Methods of using
The present invention relates to Salmonella enterica comprising at least pgl operon of Campylobacter jejuni or a functional derivative thereof and presenting at least one N-glycan of Campylobacter jejuni or N-glycan derivative thereof on its cell surface and, in particular, to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventing Campylobacter and optionally Salmonella infections and methods for producing these Salmonella strains.
1. A method of using Salmonella enterica , including but not limited to live Salmonella enterica , for preparing a medicament, including but not limited to a vaccine, wherein the Salmonella enterica comprises at least one pgl operon of Campylobacter jejuni and further comprises at least one N-glycan of Campylobacter jejuni on its cell surface, wherein one or more genes for bacillosamine biosynthesis are inactivated by mutation or partial or complete deletion.
2. The method of use of claim 1 for preparing a medicament, including but not limited to a vaccine for the prevention or treatment of Campylobacter jejuni and optionally Salmonella infections.
3. The method of use of claim 2 wherein the infections to be treated are infections in livestock, including but not limited to cattle and poultry.
4. A method for treating or preventing C. jejuni and optionally Salmonella infections, comprising administration of Salmonella enterica , via a delivery medium including but not limited to pharmaceutical composition, food or feed, to a human or animal in need thereof in a physiologically active amount, wherein the Salmonella enterica comprises at least one pgl operon of Campylobacter jejuni and further comprises at lest one N-glycan of Campylobacter jejuni on its cell surface, and wherein one or more genes for bacillosamine biosynthesis are inactivated by mutation or partial or complete deletion.