Imidazole compound and liposome containing same
Provided are a novel imidazole compound which has a high stability of the compound itself; and a novel imidazole compound which is useful as a membrane-constituting lipid of liposomes. Disclosed are a compound represented by the following General Formula (1), and a liposome containing the same compound. In the formula, Z is an imidazolyl group which may be substituted, L 1 is an alkylene group having 1 to 4 carbon atoms which may be substituted, X is an oxygen atom or a nitrogen-containing substituent, n is an integer of 2 to 4, m is an integer of 1 to 20, L 2 is a divalent linking group having 1 to 6 carbon atoms, Y is a nitrogen-containing group, R 1 and R 2 are a hydrogen group or an alkyl group having 1 to 6 carbon atoms, R 3 is a hydrogen atom or a substituent, and R 4 and R 5 are an alkyl group having 1 to 40 carbon atoms.
1. A compound represented by the following General Formula (1):
in Formula (1),
Z is an imidazolyl group which may have a substituent,
L 1 is an alkylene group having 1 to 4 carbon atoms which may have a substituent, and
X is an oxygen atom or a group represented by the following Formula (2),
* is a position of bonding,
n is an integer of 2 to 4,
m is an integer of 1 to 20,
L 2 is a divalent linking group having 1 to 6 carbon atoms, and
Y is a group represented by the following Formula (3),
R 1 and R 2 are the same or different and are a hydrogen atom or an alkyl group having 1 to 6 carbon atoms,
R 3 is a hydrogen atom or a substituent, and
R 4 and R 5 are the same or different and are an alkyl group having 1 to 40 carbon atoms.
2. The compound according to claim 1 , wherein L 1 is an alkylene group represented by the following Formula (4):
in the formula, * represents a position of bonding.
3. A liposome comprising the compound according to claim 1 .
4. A liposome comprising the compound according to claim 2 .