Patent
The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium . More specifically, the invention relates to an Enterococcus faecalis and/or Enterococcus faecium antigen which comprises at least one unit having the following general formula:
1. A vaccine comprising an isolated immunogenic Enterococcus faecalis antigen and an immunologically effective amount of an adjuvant, wherein the isolated antigen consists of, or consists essentially of, one or more units of Formula I:
wherein R 1 is OH, X is O, Y is O and CA is lactyl.
2. The vaccine of claim 1 , wherein the isolated antigen consists of two sugars, wherein the two sugars are in the D configuration.
3. The vaccine of claim 1 , wherein the isolated antigen consists of one or more units of the following formula:
wherein R 1 is OH, X is O, Y is O and CA is lactyl.
4. The vaccine of claim 1 , wherein the isolated antigen has a molecular weight of approx, 1000-200000 Da.
5. The vaccine of claim 1 , wherein the isolated antigen consists of at least 5 units of Formula I per molecule.
6. The vaccine of claim 1 , wherein the isolated antigen is bound to a support.
7. The vaccine of claim 1 , wherein the binding to the support is covalent binding.
8. The vaccine of claim 1 wherein the isolated antigen consists of one or more units
of Formula I:
wherein R 1 is OH, X is O, Y is O and CA is lactyl.
9. The vaccine of claim 1 , wherein the isolated antigen consists essentially of one or more units of Formula I:
wherein R 1 is OH, X is O, Y is O and CA is lactyl.