Immunogenic fusion polypeptides
In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response against Neisseria meningitidis in a mammal.
1. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 2.
2. The isolated polypeptide according to claim 1 , wherein the amino acid sequence is encoded by SEQ ID NO: 4.
3. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 8.
4. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 14.
5. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 16.
6. An isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 18.