Peptide and a use thereof
A peptide (SEQ ID NO:5), the use of the peptide for the inhibition of the activity of influenza virus and a pharmaceutical composition containing the peptide are described.
1. A method for the inhibition of the activity of an influenza virus in a subject, said method comprising the step of administering to the subject in need thereof an effective amount of a peptide consisting of the amino acid sequence of DEAQETAVSSHEQD (SEQ ID NO: 5).
2. The method of claim 1 , wherein the influenza virus is a human influenza virus.
3. The method of claim 1 , wherein the influenza virus is an influenza A virus.
4. The method of claim 3 , wherein the influenza A virus is selected from the group consisting of H1N1, H1N2, and H5N1.
5. The method of claim 3 , wherein the influenza A virus is H1N1.
6. The method of claim 3 , wherein the influenza A virus is H5N1.
7. The method of claim 1 , wherein the subject is selected from the group consisting of human, non-human mammal, and domestic poultry.
8. The method of claim 1 , wherein the subject is human.
9. The method of claim 1 , wherein the peptide is a fragment of rabbit α1-antiproteinase F.
10. The method of claim 1 , wherein the peptide matches with residues 1-14 of rabbit α1-antiproteinase F.
11. The method of claim 1 , wherein the peptide is a recombinant peptide.
12. The method of claim 1 , wherein the peptide is a natural peptide.
13. The method of claim 1 , wherein the peptide is a synthetic peptide.