Granted Patent
B2
US 9,840,564 · App. 15/221,255 · Granted Dec 12, 2017
Cytotoxic benzodiazepine derivatives
Inventors:
Wei Li (Acton, MA); Michael Louis Miller (Framingham, MA); Nathan Elliott Fishkin (Weymouth, MA); Ravi V. J. Chari (Newton, MA)
Assignee:
IMMUNOGEN, INC.
C07K16/30A61K31/5517A61K45/06A61K47/545A61K47/6803A61K47/6849A61K47/6851A61K47/6867C07D487/04C07D519/00A61K2039/505C07K2317/24C07K2317/92C07K2317/94
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Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Claims (4)
1. A compound represented by one of the following formulas:
or a salt thereof.
2. The compound of claim 1 , wherein the compound is represented by the following formula:
3. The compound of claim 1 , wherein the compound is represented by the following formula:
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 26, 2016
From: LI, WEI; MILLER, MICHAEL LOUIS; FISHKIN, NATHAN ELLIOTT; CHARI, RAVI V.J.
To: IMMUNOGEN, INC.
Reel/Frame 039556/0762 →
Continuity (8)
Provisional Application
61483499
· May 6, 2011
Provisional Application
61443062
· Feb 15, 2011
Provisional Application
61443092
· Feb 15, 2011