Implant and method for manufacturing same
A method for manufacturing an implant and an implant, in particular an intraluminal endoprosthesis, including a body having a coating on at least a portion of the surface thereof, and the degradation of which can be influenced from the outside in a targeted manner, the method having the following steps: a) providing an implant body, and b) applying a coating to the surface of the implant body, wherein the coating comprises unfilled cavities, preferably in the form of microbubbles ( 2 ).
1. A method for manufacturing a biodegradable implant comprising the following steps:
a) providing an implant body;
b) applying a pharmaceutical layer to the implant body, wherein the pharmaceutical layer comprises a pharmaceutically active substance; and
c) applying a coating comprising rupturable, unfilled microbubbles over the pharmaceutical layer, wherein the microbubbles are configured to rupture by way of ultrasonic excitation.
2. The method according to claim 1 , wherein the microbubbles are formed of polylactic acid (PLA) and the pharmaceutically active substance is hyaluronic acid.
3. A biodegradable implant comprising a body at least partially coated with a pharmaceutical layer and over the pharmaceutical layer is a coating of microbubbles filled with inert gas and configured to rupture by way of ultrasonic excitation.
4. The implant according to claim 3 , characterized in that the implant body comprises struts, wherein a luminal side of the struts comprises recesses coated with the microbubbles.
5. A biodegradable implant comprising a body at least partially coated with a pharmaceutical layer coated with microbubbles filled with inert gas and configured to rupture by way of ultrasonic excitation, characterized in that the microbubbles are attached to a surface of the implant body using an embedding matrix, wherein the matrix comprises at least one material selected from the group consisting of a polymer, a lipid, a citrate-based softening agent, a protein and a peptide.
6. The implant according to claim 3 , wherein the gas comprises molecules sized to prevent diffusion of the molecules through shells of the microbubbles.
7. The implant according to claim 3 , wherein the gas comprises perfluorocarbons or sulphur tetrafluoride.