Compounds as TNIK, IKKε and TBK1 inhibitors and pharmaceutical composition comprising same

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:

wherein,

X is CH;

Y is CH 2 ;

n is 1;

R 1 is —NH—C(═O)—R 4 ;

R 2 is C 6-14 aryl, 5- to 10-membered heteroaryl, or —NH—R 17 ; and

R 3 is H or C 1-7 alkyl;

R 4 is C 1-7 alkyl, C 6-14 aryl, or 5- to 10-membered heteroaryl; and

R 17 is C 6-14 aryl or 5- to 10-membered heteroaryl;

wherein said C 6-14 aryl or 5- to 10-membered heteroaryl is optionally substituted with one or more substituents selected from the group consisting of C 1-7 alkyl; —OCF 3 ; C 1-7 alkoxy; (C 1-7 alkoxy)carbonyl; (C 1-7 alkyl)carbonyl; C 6-14 aryl; (C 1-7 alkyl)thio; halogen; (C 1-7 alkyl)sulfonyl; —NH—R 20 —R 21 ; —N(CH 3 )—R 20 —R 21 ; 5- to 10-membered heteroaryl; heterocycloalkyl unsubstituted or substituted with C 1-7 alkyl or amino; (C 1-7 alkylcarbonylamino)(C 6-14 aryl); (heterocycloalkyl)-(C 1-7 alkyl)-(5- to 10-membered heteroaryl); —CF 3 ; cyano; (C 1-7 alkyl)amino; nitro; oxo; (heterocycloalkyl)-(C 1-7 alkoxy); (diC 1-7 alkyl)amino; (C 1-7 alkyl)carbonylamino; hydroxy; (heterocycloalkyl)-(C 1-7 alkyl); (tertbutoxycarbonyl)-(heterocycloalkyl)-(C 1-7 alkyl); benzyl; and amino, wherein R 20 is C 6-14 aryl, 5- to 10-membered heteroaryl or C 1-7 alkyl which is unsubstituted or substituted with hydroxy; and R 21 is 5- to 10-membered heteroaryl or heterocycloalkyl which is unsubstituted or substituted with H, hydroxy, halogen, amino, C 1-7 alkyl, (diC 1-7 alkyl)amino, C 1-7 alkylcarbonylamino, C 1-7 alkoxy, methyl or oxo;

wherein said 5- to 10-membered heteroaryl is a mono or bicyclic heteroaryl comprising one to three heteroatoms selected from the group consisting of O, N, and S and

wherein said heterocycloalkyl is selected from the group consisting of pyrrolidinyl, piperidinyl, morpholino, azepanyl and piperazinyl.

2. The compound of claim 1 , wherein R 4 is C 1-4 alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted thiophenyl, substituted or unsubstituted furanyl, or substituted or unsubstituted pyridinyl.

3. The compound of claim 2 , wherein said phenyl, thiophenyl, furanyl, or pyridinyl is substituted with one or more substituents selected from the group consisting of fluoro, chloro, bromo, nitro, cyano, amino, tertbutyloxycarbonyl, methyl, methylthio, methylsulfonyl, methoxy, acetamido, methylpiperazinyl, aminopiperidinyl, morpholino, morpholinoethoxy, methylamino, dimethylamino, dimethylaminoethylamino, dimethylaminopropylamino, aminoethylamino, hydroxyethylamino, hydroxypropylamino, hydroxybutylamino, methoxyethylamino, methoxypropylamino, methyl(2-(methylamino)ethyl)amino, acetamidoethylamino, pyrrolidinylethylamino, pyrrolidinylpropylamino, piperidinylethylamino, piperidinylpropylamino, azepanylethylamino, morpholinoethylamino, morpholinopropylamino, methylpiperazinylethylamino, methylpiperazinylpropylamino, thiophenylmethylamino, oxopyrrolidinylpropylamino, and (2-hydroxy-3-(piperidinyl)propyl)amino.

4. The compound of claim 1 , wherein R 2 is substituted or unsubstituted phenyl, thiazolyl, pyrazolyl, imidazolyl, triazolyl, pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, pyrimidinyl, thiophenyl, furanyl, benzo[d]oxazol-7-yl, quinolinyl, indolyl, benzo[d]imidazolyl or benzofuranyl.

5. The compound of claim 1 , wherein R 2 is selected from the group consisting of thiazolyl; pyrazolyl; methylpyrazolyl; imidazolyl; methylimidazolyl; triazolyl; methyltriazolyl; pyridinyl; chloropyridinyl; fluoropyridinyl; methoxyphenylaminopyridinyl; methoxypyridinyl; phenyl-1H-pyrrolo[2,3-b]pyridinyl; 1H-pyrrolo[2,3-b]pyridinyl; acetamidophenyl-1H-pyrrolo[2,3-b]pyridinyl; morpholinomethylthiophenyl-1H-pyrrolo[2,3-b]pyridinyl; pyrimidinyl; dichloropyrimidinyl; methoxyphenylaminopyrimidinyl; methylpyrazolylaminopyrimidinyl; phenylaminopyrimidinyl; fluorophenylaminopyrimidinyl; acetamidophenylaminopyrimidinyl; methylpiperazinylpyrimidinyl; morpholinopyrimidinyl; tolylaminopyrimidinyl; chloropyrimidinyl; thiophenyl; pyrrolidinylmethylthiophenyl; piperidinylmethylthiophenyl; morpholinomethylthiophenyl; tertbutyloxycarbonylpiperazinylmethylthiophenyl; furanyl; benzo[d]oxazol-7-yl; methyl-benzo[d]oxazol-7-yl; quinolinyl; indolyl; benzo[d]imidazolyl; and benzofuranyl.

6. The compound of claim 1 , wherein R 3 is methyl.

7. The compound of claim 1 , which is selected from the group consisting of:

(1) N-(7-(2-ethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(2) N-(7-(3-isopropylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(3) N-(7-(4-(tert-butyl)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(4) N-(3-oxo-7-(2-(trifluoromethoxy)phenyl)isoindolin-4-yl)benzamide;

(5) N-(3-oxo-7-(3-(trifluoromethoxy)phenyl)isoindolin-4-yl)benzamide;

(6) N-(7-(2-isopropoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(7) N-(7-(3-isopropoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(8) methyl 2-(7-benzamido-1-oxoisoindolin-4-yl)benzoate;

(9) methyl 3-(7-benzamido-1-oxoisoindolin-4-yl)benzoate;

(10) methyl 4-(7-benzamido-1-oxoisoindolin-4-yl)benzoate;

(11) N-(7-(2-acetylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(12) N-(7-(3-acetylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(13) N-(7-(4-acetylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(14) N-(7-(2-(methylthio)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(15) N-(7-(2,4-difluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(16) N-(7-(2,3-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(17) N-(7-(2,3-dichlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(18) N-(7-(2,4-dichlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(19) N-(7-(2,5-dichlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(20) N-(7-(3,4-dichlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(21) N-(7-(3,5-dichlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(22) N-(7-(4-fluoro-2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(23) N-(7-(2-chloro-3-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(24) N-(7-(2-fluoro-3-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(25) N-(3-oxo-7-(2,3,4-trimethoxyphenyl)isoindolin-4-yl)benzamide;

(26) N-(7-(3,4-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(27) N-(7-(3,5-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(28) N-(7-(2,6-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(30) N-(7-(3,5-difluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(31) N-(7-(2,5-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(32) N-(7-(2,5-difluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(33) N-(7-(3,4-difluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(34) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(38) N-(7-(2,4-dimethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(39) N-(7-(4-ethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(40) N-(7-(4-isopropoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(41) N-(7-(4-(methylthio)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(42) N-(7-(3-ethylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(43) N-(3-oxo-7-(2-propoxyphenyl)isoindolin-4-yl)benzamide;

(44) N-(3-oxo-7-(3-propoxyphenyl)isoindolin-4-yl)benzamide;

(45) N-(7-(2-butoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(46) N-(7-(3-butoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(47) N-(7-(2-(methylsulfonyl)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(48) N-(7-(3-fluoro-2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(49) N-(7-(4-chloro-2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(50) N-(7-(3-chloro-2-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(51) N-(3-oxo-7-(thiazol-5-yl)isoindolin-4-yl)benzamide;

(52) N-(3-oxo-7-(thiazol-4-yl)isoindolin-4-yl)benzamide;

(53) N-(3-oxo-7-(thiazol-2-yl)isoindolin-4-yl)benzamide;

(54) N-(7-(1H-imidazol-4-yl)-3-oxoisoindolin-4-yl)benzamide;

(55) N-(3-oxo-7-(1H-pyrazol-4-yl)isoindolin-4-yl)benzamide;

(56) N-(7-(1-methyl-1H-imidazol-5-yl)-3-oxoisoindolin-4-yl)benzamide;

(57) N-(7-(1-methyl-1H-pyrazol-4-yl)-3-oxoisoindolin-4-yl)benzamide;

(58) N-(3-oxo-7-(1H-1,2,4-triazol-5-yl)isoindolin-4-yl)benzamide;

(59) N-(7-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxoisoindolin-4-yl)benzamide;

(88) 3-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(89) 4-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(90) 3-chloro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(91) 2,4-difluoro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(92) 3,4-difluoro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(93) 3,4-dimethyl-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(94) 2-(dimethylamino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(95) 3-(dimethylamino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(96) 2-(methylthio)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(97) 3-(methylthio)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(98) 2-(methylsulfonyl)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(99) 3-(methylsulfonyl)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(100) 4-(methylsulfonyl)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(101) 2,4-dimethoxy-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(102) 3,4-dimethoxy-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(103) 2,4-dichloro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(104) 3,4-dichloro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(105) 2,4-dimethyl-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(106) 2-acetamido-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(107) 3-acetamido-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(108) 4-(methylamino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(109) 3-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(110) 4-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(111) 5-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(112) N-(3-oxo-7-(o-tolyl)isoindolin-4-yl)benzamide;

(113) N-(3-oxo-7-(m-tolyl)isoindolin-4-yl)benzamide;

(114) N-(3-oxo-7-(2-(trifluoromethyl)phenyl)isoindolin-4-yl)benzamide;

(115) N-(3-oxo-7-(3-(trifluoromethyl)phenyl)isoindolin-4-yl)benzamide;

(116) 4-acetamido-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(117) N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(118) N-(7-(4-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(119) 4-nitro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(120) 4-acetamido-N-(7-(4-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(121) 4-methoxy-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(122) 4-fluoro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(123) N-(7-(4-fluorophenyl)-3-oxoisoindolin-4-yl)-4-methoxybenzamide;

(124) 4-acetamido-N-(7-(4-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(125) N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(126) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(127) N-(3-oxo-7-(pyridin-4-yl)isoindolin-4-yl)benzamide;

(128) N-(3-oxo-7-(pyridin-4-yl)isoindolin-4-yl)benzamide hydrochloride;

(129) 2-methoxy-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(130) 3-fluoro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(131) 4-(methylthio)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(132) N-(3-oxo-7-(4-propoxyphenyl)isoindolin-4-yl)benzamide;

(133) N-(7-(4-isopropylphenyl)-3-oxoisoindolin-4-yl)benzamide;

(134) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)furan-2-carboxamide;

(135) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(136) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)thiophene-2-carboxamide;

(137) 4-fluoro-2-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(138) 4-acetamido-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(139) 4-(dimethylamino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(140) 4-acetamido-N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(141) 4-fluoro-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(142) 2-fluoro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(143) 4-chloro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(144) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(145) N-(7-(3-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(146) N-(3-oxo-7-(thiophen-3-yl)isoindolin-4-yl)benzamide;

(147) N-(7-(3-cyanophenyl)-3-oxoisoindolin-4-yl)benzamide;

(148) N-(7-(3-(dimethylamino)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(149) N-(7-(2-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(150) N-(7-(furan-3-yl)-3-oxoisoindolin-4-yl)benzamide;

(151) N-(7-(3-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(152) N-(3-oxo-7-(pyridin-3-yl)isoindolin-4-yl)benzamide;

(153) N-(3-oxo-7-(pyridin-3-yl)isoindolin-4-yl)benzamide hydrochloride;

(154) N-(3-oxo-7-(pyrimidin-5-yl)isoindolin-4-yl)benzamide;

(155) 3-chloro-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(156) 5-bromo-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(157) 3-bromo-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(158) 4-fluoro-N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(159) N-(3-oxo-7-phenylisoindolin-4-yl)pentanamide;

(160) N-(3-oxo-7-phenylisoindolin-4-yl)acetamide;

(161) N-(7-(2-chloropyrimidin-4-yl)-3-oxoisoindolin-4-yl)acetamide;

(162) N-(7-(2-((3-methoxyphenyl)amino)pyrimidin-4-yl)-3-oxoisoindolin-4-yl)acetamide;

(163) N-(7-(2-((3-fluorophenyl)amino)pyrimidin-4-yl)-3-oxoisoindolin-4-yl)acetamide;

(164) N-(3-oxo-7-(2-(m-tolylamino)pyrimidin-4-yl)isoindolin-4-yl)acetamide;

(165) N-(3-oxo-7-(2-(p-tolylamino)pyrimidin-4-yl)isoindolin-4-yl)acetamide;

(166) N-(7-(2-((3-methoxyphenyl)amino)pyrimidin-4-yl)-3-oxoisoindolin-4-yl)propionamide;

(167) N-(7-(4-(methylsulfonyl)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(168) N-(7-(3-(methylsulfonyl)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(169) N-(7-(3-acetamidophenyl)-3-oxoisoindolin-4-yl)benzamide;

(170) 5-chloro-N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(171) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(172) N-(7-(3,5-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(174) N-(7-(2-chlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(175) N-(7-(2,4-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(176) N-(7-(3,4-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(177) N-(7-(3-ethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(178) N-(7-(2,5-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(179) N-(7-(4-chlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(180) N-(7-(3-chlorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(181) N-(7-(4-ethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(182) N-(7-(2-ethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(183) N-(7-(2-cyanophenyl)-3-oxoisoindolin-4-yl)benzamide;

(184) N-(7-(4-butoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(185) N-(7-(2-(dimethylamino)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(186) N-(3-oxo-7-(4-(trifluoromethoxy)phenyl)isoindolin-4-yl)benzamide;

(187) N-(7-(2,6-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(188) N-(3-oxo-7-(4-propylphenyl)isoindolin-4-yl)benzamide;

(189) N-(7-(2,3-dihydroxyphenyl)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(190) 4-fluoro-N-(7-(2-hydroxy-3-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(191) 4-fluoro-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(192) 5-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)furan-2-carboxamide;

(193) N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(194) 4-fluoro-N-(7-(2-methylbenzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)benzamide;

(195) N-(3-oxo-7-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)isoindolin-4-yl)benzamide;

(196) N-(3-oxo-7-(5-(piperidin-1-ylmethyl)thiophen-2-yl)isoindolin-4-yl)benzamide;

(197) N-(7-(5-(morpholinomethyl)thiophen-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(198) tert-butyl 4-((5-(7-benzamido-1-oxoisoindolin-4-yl)thiophen-2-yl)methyl)piperazine-1-carboxylate;

(199) N-(7-(6-fluoropyridin-3-yl)-3-oxoisoindolin-4-yl)benzamide;

(200) N-(7-(6-methoxypyridin-3-yl)-3-oxoisoindolin-4-yl)benzamide;

(201) 2-chloro-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(202) 3-methoxy-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(203) N-(3-oxo-7-phenylisoindolin-4-yl)thiophene-2-carboxamide;

(204) N-(7-(4-acetylphenyl)-3-oxoisoindolin-4-yl)-4-methoxybenzamide;

(205) N-(7-(4-fluorophenyl)-3-oxoisoindolin-4-yl)benzamide;

(206) N-(7-(4-(dimethylamino)phenyl)-3-oxoisoindolin-4-yl)benzamide;

(207) N-(7-(4-cyanophenyl)-3-oxoisoindolin-4-yl)benzamide;

(208) 4-cyano-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(209) N-(3-oxo-7-(p-tolyl)isoindolin-4-yl)benzamide;

(210) N-(3-oxo-7-(4-(trifluoromethyl)phenyl)isoindolin-4-yl)benzamide;

(211) N-(3-oxo-7-phenylisoindolin-4-yl)isonicotinamide;

(212) N-(3-oxo-7-phenylisoindolin-4-yl)furan-2-carboxamide;

(213) N-(3-oxo-7-phenylisoindolin-4-yl)nicotinamide;

(214) 4-fluoro-N-(3-oxo-7-(quinolin-6-yl)isoindolin-4-yl)benzamide;

(215) 4-fluoro-N-(3-oxo-7-(quinolin-5-yl)isoindolin-4-yl)benzamide;

(216) 4-fluoro-N-(3-oxo-7-(quinolin-4-yl)isoindolin-4-yl)benzamide;

(217) N-(7-(1H-indol-7-yl)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(218) N-(7-(1H-benzo[d]imidazol-4-yl)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(219) N-(7-benzyl-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(220) (R)-tert-butyl 2-((3-oxo-7-phenylisoindolin-4-yl)carbamoyl)pyrrolidine-1-carboxylate;

(221) (R)—N-(3-oxo-7-phenylisoindolin-4-yl)pyrrolidine-2-carboxamide;

(222) 3-amino-N-(2-methyl-3-oxo-7-phenylisoindolin-4-yl)benzamide;

(223) 2-amino-N-(2-methyl-3-oxo-7-phenylisoindolin-4-yl)benzamide;

(224) N-(7-(2,3-dimethoxyphenyl)-2-(furan-2-carbonyl)-3-oxoisoindolin-4-yl)furan-2-carboxamide;

(225) N-(7-(2,3-dimethoxyphenyl)-3-oxo-2-(thiophene-2-carbonyl)isoindolin-4-yl)thiophene-2-carboxamide;

(280) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(287) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(288) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-methoxyethyl)amino)benzamide;

(289) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(290) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-morpholinoethyl)amino)benzamide;

(291) 4-((2-(dimethylamino)ethyl)amino)-N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(292) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-hydroxyethyl)amino)benzamide;

(293) 4-((2-(azepan-1-yl)ethyl)amino)-N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(294) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((2-(4-methylpiperazin-1-yl)ethyl)amino)benzamide;

(295) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzamide;

(296) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-morpholinopropyl)amino)benzamide;

(297) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-morpholinoethyl)amino)benzamide;

(298) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(299) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(300) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-methoxyethyl)amino)benzamide;

(301) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(dimethylamino)ethyl)amino)benzamide;

(302) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(303) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide hydrochloride;

(304) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide hydrochloride;

(305) 4-((2-(dimethylamino)ethyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(306) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(dimethylamino)propyl)amino)benzamide;

(307) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(308) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(309) 2-methyl-N-(3-oxo-7-phenylisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(310) 4-((3-methoxypropyl)amino)-N-(7-(2-methoxypyridin-3-yl)-3-oxoisoindolin-4-yl)benzamide;

(311) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-hydroxyethyl)amino)benzamide;

(312) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-morpholinobenzamide;

(313) N-(7-(3-fluoro-2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(314) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(4-methylpiperazin-1-yl)ethyl)amino)benzamide;

(315) 4-((2-aminoethyl)amino)-N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(316) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzamide;

(317) N-(3-oxo-7-phenylisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(318) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(319) 4-(4-methylpiperazin-1-yl)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(320) 4-morpholino-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(321) 4-((2-methoxyethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(322) 4-((2-morpholinoethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(323) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-morpholinobenzamide;

(324) 4-((2-methoxyethyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(325) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-(4-methylpiperazin-1-yl)benzamide;

(326) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-morpholinoethyl)amino)benzamide;

(327) 4-((3-morpholinopropyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(328) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-morpholinopropyl)amino)benzamide;

(329) 4-((3-(4-methylpiperazin-1-yl)propyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(330) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzamide;

(331) 4-((3-methoxypropyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(332) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-methoxypropyl)amino)benzamide;

(333) N-(3-oxo-7-phenylisoindolin-4-yl)-4-((thiophen-2-ylmethyl)amino)benzamide;

(334) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((thiophen-2-ylmethyl)amino)benzamide;

(335) 4-((3-(dimethylamino)propyl)amino)-N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)benzamide;

(336) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((3-methoxypropyl)amino)benzamide;

(337) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((3-morpholinopropyl)amino)benzamide;

(338) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(339) N-(7-(furan-2-yl)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(340) 4-(4-aminopiperidin-1-yl)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(341) N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-44(2-(dimethylamino)ethyl)amino)benzamide;

(342) N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(343) N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(344) 4-((2-(azepan-1-yl)ethyl)amino)-N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)benzamide;

(345) 4-(2-morpholinoethoxy)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(346) N-(3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(347) N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)-4-(2-morpholinoethoxy)benzamide;

(348) N-(7-(3-amino-2-hydroxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-morpholinoethyl)amino)benzamide;

(349) 4-((2-(azepan-1-yl)ethyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(350) 4-((2-(azepan-1-yl)ethyl)amino)-N-(7-(2,3-dimethoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(351) 4-((3-(dimethylamino)propyl)amino)-N-(7-(2-hydroxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(352) 4-((2-hydroxyethyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(353) 4-((2-hydroxyethyl)amino)-N-(7-(2-hydroxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(354) 4-((3-hydroxypropyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(355) N-(7-(2-hydroxyphenyl)-3-oxoisoindolin-4-yl)-4-((3-hydroxypropyl)amino)benzamide;

(356) 4-((4-hydroxybutyl)amino)-N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(357) 4-((4-hydroxybutyl)amino)-N-(7-(2-hydroxyphenyl)-3-oxoisoindolin-4-yl)benzamide;

(358) 4-(methyl(2-(methylamino)ethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(359) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((2-morpholinoethyl)amino)benzamide;

(360) N-(3-oxo-7-phenylisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(361) N-(7-(2-methoxyphenyl)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(362) 4-((2-(dimethylamino)ethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(363) N-(3-oxo-7-phenylisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(364) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(365) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide hydrochloride;

(366) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide hydrochloride;

(367) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((2-(dimethylamino)ethyl)amino)benzamide;

(368) N-(7-(2,3-difluorophenyl)-3-oxoisoindolin-4-yl)-4-((3-(dimethylamino)propyl)amino)benzamide;

(369) 4-((2-(azepan-1-yl)ethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(370) N-(3-oxo-7-phenylisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(371) 4-((2-hydroxyethyl)amino)-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(372) 4-((2-methoxyethyl)amino)-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(373) 4-((2-(dimethylamino)ethyl)amino)-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(374) N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(375) 4-((2-morpholinoethyl)amino)-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(376) N-(7-(benzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(377) N-(7-(2-methylbenzo[d]oxazol-7-yl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(378) 4-((2-(4-methylpiperazin-1-yl)ethyl)amino)-N-(3-oxo-7-(thiophen-2-yl)isoindolin-4-yl)benzamide;

(379) 4-((2-(4-methylpiperazin-1-yl)ethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(380) 4-((2-hydroxyethyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(381) 4-((3-(dimethylamino)propyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(382) 4-((3-hydroxypropyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(383) 4-((4-hydroxybutyl)amino)-N-(3-oxo-7-phenylisoindolin-4-yl)benzamide;

(384) N-(7-(benzofuran-2-yl)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(385) N-(3-oxo-7-(quinolin-6-yl)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(386) N-(3-oxo-7-(quinolin-5-yl)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(387) N-(3-oxo-7-(quinolin-4-yl)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(408) 4-fluoro-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(409) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(410) N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(411) N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)benzamide;

(412) N-(3-oxo-7-(p-tolylamino)isoindolin-4-yl)benzamide;

(413) N-(7-((2-fluorophenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(414) N-(7-((4-fluorophenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(415) N-(7-((3-fluorophenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(416) N-(7-((4-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(417) 4-methyl-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(418) N-(7-((3-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(419) N-(7-((2-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(420) 2-fluoro-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(421) 3-fluoro-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(422) N-(7-((2,3-dimethoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(423) N-(7-((3,5-bis(trifluoromethyl)phenyl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(424) N-(7-((2,3-dimethylphenyl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(425) 4-fluoro-N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(426) 4-fluoro-N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)benzamide;

(427) 4-fluoro-N-(3-oxo-7-(pyridin-3-ylamino)isoindolin-4-yl)benzamide;

(428) 4-fluoro-N-(3-oxo-7-(pyridin-2-ylamino)isoindolin-4-yl)benzamide;

(429) 4-fluoro-N-(3-oxo-7-(pyrazin-2-ylamino)isoindolin-4-yl)benzamide;

(430) 4-fluoro-N-(7-((l-methyl-1H-pyrazol-4-yl)amino)-3-oxoisoindolin-4-yl)benzamide;

(431) N-(7-((3-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)benzamide;

(432) 2-methoxy-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(433) 4-methoxy-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(434) 3-methoxy-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(435) 4-acetamido-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(436) N-(3-oxo-7-(m-tolylamino)isoindolin-4-yl)benzamide;

(437) N-(7-((1H-pyrazol-3-yl)amino)-3-oxoisoindolin-4-yl)-4-fluorobenzamide;

(438) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(439) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(440) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide hydrochloride;

(441) 4-((2-(dimethylamino)ethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(442) 4-((2-morpholinoethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(443) 4-((2-(4-methylpiperazin-1-yl)ethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(444) 4-((2-methoxyethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(445) N-(7-((3-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(446) N-(7-((3-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(447) N-(7-((3-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(448) N-(7-((3-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(449) N-(3-oxo-7-(m-tolylamino)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(450) N-(3-oxo-7-(m-tolylamino)isoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(451) N-(3-oxo-7-(m-tolylamino)isoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(452) N-(3-oxo-7-(m-tolylamino)isoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(453) N-(7-((2-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(454) N-(7-((2-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(455) N-(7-((3-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(456) N-(7-((3-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(457) N-(7-((3-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(458) N-(7-((3-chlorophenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(459) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((3-(2-oxopyrrolidin-1-yl)propyl)amino)benzamide;

(460) 4-((3-(dimethylamino)propyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(461) 4-((3-morpholinopropyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(462) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(463) 4-((3-(4-methylpiperazin-1-yl)propyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(464) 4-((3-hydroxypropyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(465) N-(7-((3,5-bis(trifluoromethyl)phenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(466) N-(7-((3,5-bis(trifluoromethyl)phenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(467) N-(7-((3,5-bis(trifluoromethyl)phenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(468) N-(7-((3,5-bis(trifluoromethyl)phenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(469) N-(7-((2,3-dimethylphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(470) N-(7-((2,3-dimethylphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(471) N-(7-((2,3-dimethylphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(472) N-(7-((2,3-dimethylphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(473) N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(474) N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide;

(475) N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(476) N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)-4-((3-(pyrrolidin-1-yl)propyl)amino)benzamide;

(477) N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(478) N-(7-((2-methoxyphenyl)amino)-3-oxoisoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(479) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(480) N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide hydrochloride;

(481) 4-((2-aminoethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(482) N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)-4-((2-(piperidin-1-yl)ethyl)amino)benzamide;

(483) N-(3-oxo-7-(o-tolylamino)isoindolin-4-yl)-4-((3-(piperidin-1-yl)propyl)amino)benzamide;

(484) 4-((4-hydroxybutyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(485) 4-((2-acetamidoethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(486) 4-((3-aminopropyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(487) 4-((2-hydroxyethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(488) 4-((2-hydroxy-3-(piperidin-1-yl)propyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(489) (S)-4-((2-hydroxy-3-(piperidin-1-yl)propyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(490) (R)-4-((2-hydroxy-3-(piperidin-1-yl)propyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(491) 4-(4-aminopiperidin-1-yl)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide;

(492) 4-((2-(azepan-1-yl)ethyl)amino)-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide, and

a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition, which comprises the compound according to claim 1 and one or more pharmaceutically acceptable additives.

9. A pharmaceutical composition, which comprises the compound according to claim 2 and one or more pharmaceutically acceptable additives.

10. A pharmaceutical composition, which comprises the compound according to claim 3 and one or more pharmaceutically acceptable additives.

11. A pharmaceutical composition, which comprises the compound according to claim 4 and one or more pharmaceutically acceptable additives.

12. A pharmaceutical composition, which comprises the compound according to claim 5 and one or more pharmaceutically acceptable additives.

13. A pharmaceutical composition, which comprises the compound according to claim 6 and one or more pharmaceutically acceptable additives.

14. A pharmaceutical composition, which comprises the compound according to claim 7 and one or more pharmaceutically acceptable additives.