Compounds useful as immunomodulators

1. A compound of Formula (I):

or salts thereof, wherein:

Ring B is phenyl or thienyl;

Ring A is:

wherein A″ is CH or N, and wherein one of R 1 and R 2 is Q and the other of R 1 and R 2 is R b ;

R 3 is H or —CH 2 C(O)OH;

R 4 is —NHCH 2 CH 2 NHC(O)CH 3 ;

Q is:

(i)

wherein R y is —OH, —CH 3 , —CH 2 OH, —C(O)OH, —CH 2 C(O)OH, or —C(O)NHCH 2 CH 2 OH, —C(O)NH 2 , —NHC(O)CH 3 , and R z is —OH, —CH 3 , —OCH 3 , —OC(O)CH 3 , or —CH 2 CH═CH 2 and R h is —CH 3 or —C(O)CH 3 ;

(ii) —CH 2 NH—R x wherein R x is cyclobutyl, —(CH 2 )cyclobutyl optionally substituted with two fluorine atoms, cyclopropyl, hydroxycyclopentyl, cyclopentyl, cyclohexyl, hydroxycyclohexyl, hydroxytetrahydrofuranyl, N-methyl piperidinyl, N-ethyl piperidinyl, hydroxytetrahydrothienyl, or

(iii) —CH 2 NR a —CR a R a —(CH 2 ) n —R x wherein R x is hydrogen, azetidinonyl, cyclohexyl, hydroxyphenyl, pyrrolidinonyl, piperidinonyl, piperazinonyl, morpholinyl, imidazolyl, N-methylimidazolyl, —C(O)(morpholinyl), piperazinyl optionally substituted with a methyl, phenyl, alkoxyphenyl, hydroxyphenyl, pyridinyl, pyrimidinyl, or —C(O)OC(CH 3 ) 3 group, pyrrolidinyl, pyridinyl, thiomorpholine dioxide, or methyl triazolyl; or

(iv) —CHR a —NR a —CR a R a —(CHR a ) n —R x wherein R x is —OH, —OCH 3 , —C(O)OH, —OPh, —CH(CO 2 H)—NHC(O)CH 3 , —O(CH 2 ) 2 O(CH 2 ) 2 OH, —O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 OH, —O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 CO 2 H—O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 CO 2 H, —C(O)CH 3 , —C(O)NR a R a , —C(O)NR q R q , —N(CH 3 ) 2 , —NHC(O)CH 3 , —NHC(O)Ph, —C(O)NH(CH 2 ) 2 -imidazolyl, NHC(O)OCH 2 Ph, —N(CH 3 )S(O) 2 CH 3 , —NHC(O)CH═CH 2 , —NHC(O)CH═CHC(O)CH 2 CH 3 , —NHS(O) 2 CH 3 , or

each R a is independently H, —CH(OH)CH 3 , OH, —(CH 2 ) 2 OH, —CH 2 OH, —(CH 2 ) 2 NH 2 , —CH 2 CH 3 , or —CH 3 ; or, two R a groups on the same carbon atom can form a four, five-, or six-membered carbocyclic ring, an N-methylpiperidinyl ring, or a pyranyl ring;

each R b is independently H, F, Cl, Br, —CF 3 , —CN, CH 3 , or —OCH 3 ;

each R c is independently —OCH 3 , —OH, —OCH 2 CH 3 , —O(CH 2 )OCH 3 , —OCH 2 CH═CH 2 , —O(CH 2 ) 2 CH 3 , —O(CH 2 ) 2 -morpholinyl, or F;

or two R c attached to adjacent carbon atoms form —O—(CH 2 ) v —O—, wherein v is 1 or 2;

each R q is selected from hydrogen, —CH 2 C(O)NHCH 2 CO 2 H, —(CH 2 )C(O)NHCH(CO 2 H)CH 2 CH(CH 3 ) 2 , —CH(Bn)-C(O)NHCH(CO 2 H)(CH 2 ) 3 NHC(NH)NH 2 ;

m is zero or 1;

n is zero, 1, 2, or 3;

each p is independently zero or 1; and

q is zero, 1, or 2.

2. The compound according to claim 1 or salts thereof, wherein Ring A is:

3. The compound according to claim 2 or salts thereof, wherein Q is:

4. The compound according to claim 2 or salts thereof, wherein Q is: —CH 2 NH—R x wherein R x is cyclobutyl, —(CH 2 )cyclobutyl optionally substituted with two fluorine atoms, cyclopropyl, hydroxycyclopentyl, cyclopentyl, cyclohexyl, hydroxycyclohexyl, hydroxytetrahydrofuranyl, N-methyl piperidinyl, N-ethyl piperidinyl, hydroxytetrahydrothienyl, or

5. The compound according to claim 2 or salts thereof, wherein Q is: —CH 2 NR a —CR a R a —(CH 2 ) n —R x wherein R x is hydrogen, azetidinonyl, cyclohexyl, hydroxyphenyl, pyrrolidinonyl, piperidinonyl, piperazinonyl, morpholinyl, imidazolyl, N-methylimidazolyl, —C(O)(morpholinyl), piperazinyl optionally substituted with a methyl, phenyl, alkoxyphenyl, hydroxyphenyl, pyridinyl, pyrimidinyl, or —C(O)OC(CH 3 ) 3 group, pyrrolidinyl, pyridinyl, thiomorpholine dioxide, or methyl triazolyl.

6. The compound according to claim 2 or salts thereof, wherein Q is —CHR a —NR a —CR a R a —(CHR a ) n —R x wherein R x is —OH, —OCH 3 , —C(O)OH, —OPh, —CH(CO 2 H)—NHC(O)CH 3 , —O(CH 2 ) 2 O(CH 2 ) 2 OH, —O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 OH, —O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 CO 2 H—O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 O(CH 2 ) 2 CO 2 H, —C(O)CH 3 , —C(O)NR a R a , —C(O)NR q R q , —N(CH 3 ) 2 , —NHC(O)CH 3 , —NHC(O)Ph, —C(O)NH(CH2)2-imidazolyl, NHC(O)OCH 2 Ph, —N(CH 3 )S(O) 2 CH 3 , —NHC(O)CH═CH 2 , —NHC(O)CH═CHC(O)CH 2 CH 3 , —NHS(O) 2 CH 3 , or

7. The compound according to claim 1 selected from: (S)-1-(2,6-dimethoxy-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid (1); 1-(4-((2′-fluoro-2-methylbiphenyl-3-yl)methoxy)benzyl)azetidine (3); N-{2-[({3-bromo-2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (4); ({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) [2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine (5); N-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}-N-methylmethanesulfonamide (6); 1-({3-bromo-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (7); 2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-(morpholin-4-yl)ethan-1-one (8); ({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[2-(4-methylpiperazin-1-yl)ethyl]amine (9); 1-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}piperidin-2-one (10); 1-{3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propyl}pyrrolidin-2-one (11); 4-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}piperazin-2-one (12); ({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[2-(morpholin-4-yl)ethyl]amine (13); 1-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (14); 2-[methyl({3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]acetic acid (15); N-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-1-ethylpiperidin-3-amine (16); 1-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}pyrrolidin-2-one (17); (2S,4R)-4-(acetyloxy)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (18); N-(2-hydroxyethyl)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) piperidine-4-carboxamide (19); ({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[1-(5-methyl-4H-1,2,4-triazol-3-yl)ethyl]amine (20); N-{2-[({3-bromo-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (21); (2S,4R)-1-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-4-methoxypyrrolidine-2-carboxylic acid (22); N-{3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propyl}acetamide (23); (1R,2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclohexan-1-ol (24); N-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-1-methylpiperidin-3-amine (25); (2S)-1-({2-methoxy-3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (26); (2S)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-2-(prop-2-en-1-yl)pyrrolidine-2-carboxylic acid (27); 3-[({3-bromo-4-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino]propanamide (28); 3-[({3-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino]propanamide (29); 4-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)morpholine-3-carboxylic acid (30); 3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butanoic acid (31); 1-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-4-carboxylic acid (32); (2R)-1-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (33); (2S)-1-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (34); 2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-N,N-dimethylacetamide (35); N-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (36); 1-({2-methoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (37); 1-({3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (38); (2S,4R)-4-methoxy-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) pyrrolidine-2-carboxylic acid (39); 1-({2,6-dimethyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (40); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azepane-2-carboxylic acid (41); 2-[1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidin-2-yl]acetic acid (42); 1-{3-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propyl}pyrrolidin-2-one (43); N-{2-[(1-{3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}ethyl)amino]ethyl}acetamide (44); 2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(methyl)amino]acetic acid (45); 3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanamide (46); (2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (47); 1-({3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) piperidine-2-carboxylic acid (48); 1-({3-fluoro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (49); (2R,4R)-4-hydroxy-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (50); (2R,4S)-4-hydroxy-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) pyrrolidine-2-carboxylic acid (51); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (52); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-3-carboxylic acid (53); (3R)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-3-carboxylic acid (54); (2R,4R)-4-methyl-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (55); (2S)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (56); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-4-carboxylic acid (57); (2R)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (58); (2S)-1-({4-methyl-3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (59); 1-{3-[({3-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino]propyl}pyrrolidin-2-one (60); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid (63); 2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-methylpropanoic acid (64); N-{2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (65); 1-({3-bromo-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (66); N-{2-[({2-methoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (67); N-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl) cyclobutanamine (68); N-{2-[({2,6-dimethyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (69); N-{2-[(1-{3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}ethyl)amino]ethyl}acetamide (70); (2S)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (71); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (72); (1R,2R)-2-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclohexan-1-ol (73); 1-({4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid (74); (2R)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)pyrrolidine-2-carboxylic acid (75); 5-{[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}pyrrolidin-2-one (76); (2S)-2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (77); (2R)-2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (78); N-{2-[({3-fluoro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (79); (2S)-2-[({2-methoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (80); (2S)-2-[({3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (81); 3-[({2-methoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanamide (82); 1-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (83); 3-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butanoic acid (84); (2R)-2-[methyl({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (85); 3-[({2,6-dimethyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanamide (86); N-{2-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (87); N-{2-[({4-methyl-3-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide (88); [(2S)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)pyrrolidin-2-yl]methanol (89); (2S)-1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine-2-carboxylic acid (90); 5-{[({4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}pyrrolidin-2-one (91); 5-{[({4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}pyrrolidin-2-one (92); (2S)-2-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (93); 2-[methyl({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]acetic acid (94); 3-[({3-methyl-4-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino]propanamide (95); (2R)-2-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (96); 1-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (97); 1-({2-methoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (98); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (99); 1-({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)azetidine (100); 2-[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethan-1-ol (102); 2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl) methoxy]phenyl}methyl)amino]ethan-1-ol (103); (2S)-2-[({3-bromo-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (104); (2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propanoic acid (105); (2R)-2-{[(2,6-dimethoxy-4-{[3-(3-methoxyphenyl)-2-methylphenyl]methoxy}phenyl)methyl]amino}propanoic acid (106); (2R)-2-{[(4-{[3-(3-fluoro-5-methoxyphenyl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}propanoic acid (107); (2R)-2-{[(4-{[3-(2H-1,3-benzodioxol-5-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}propanoic acid (108); 2-(6-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-3,4-dihydroisoquinolin-2(1H)-yl)acetic acid (2); N-[2-({5-[(2-methyl-3-phenylphenyl)methoxy]-1,2,3,4-tetrahydronaphthalen-1-yl}amino)ethyl]acetamide (61); N-[2-({6-[(2-methyl-3-phenylphenyl)methoxy]-1,2,3,4-tetrahydronaphthalen-1-yl}amino)ethyl]acetamide (62); or 6-[(2-methyl-3-phenylphenyl) methoxy]-1,2,3,4-tetrahydroisoquinoline (101); or salts thereof.

8. The compound according to claim 1 or salts thereof, selected from

N-[2-({4-[(2-methyl-3-phenylphenyl)methoxy]-2,3-dihydro-1H-inden-1-yl}amino)ethyl]acetamide;

4-{[({3-methyl-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}azetidin-2-one;

(3S)-4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

(2S)-1-[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-3-(trifluoromethyl)phenyl)methyl]piperidine-2-carboxylic acid;

N-(2-{[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-3-(trifluoromethyl)phenyl)methyl]amino}ethyl)acetamide;

(3S)-4-{[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-3-(trifluoromethyl)phenyl)methyl]amino}-3-hydroxybutanoic acid;

(2R,3S)-2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

(2R,3R)-2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

(2S,3S)-2-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

2-[({5-[(2-methyl-3-phenylphenyl)methoxy]thiophen-2-yl}methyl)amino]ethan-1-ol;

2-[({5-[(2-methyl-3-phenylphenyl)methoxy]pyridin-2-yl}methyl)amino]ethan-1-ol;

{1-[({5-[(2-methyl-3-phenylphenyl)methoxy]pyridin-2-yl}methyl)amino]cyclopentyl}methanol;

methyl({5-[(2-methyl-3-phenylphenyl)methoxy]pyridin-2-yl}methyl)amine;

5-{[({5-[(2-methyl-3-phenylphenyl)methoxy]pyridin-2-yl}methyl)amino]methyl}pyrrolidin-2-one;

2-(3,5-dimethoxy-4-{[(pyridin-2-ylmethyl)amino]methyl}phenoxymethyl)-6-phenylbenzonitrile;

2-{4-[(cyclopropylamino)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-{3,5-dimethoxy-4-[(3-methylpiperidin-1-yl)methyl]phenoxymethyl}-6-phenylbenzonitrile;

2-[3,5-dimethoxy-4-({[2-(pyrrolidin-1-yl)ethyl]amino}methyl)phenoxymethyl]-6-phenylbenzonitrile;

2-{4-[(4-hydroxypiperidin-1-yl)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-[3,5-dimethoxy-4-(morpholin-4-ylmethyl)phenoxymethyl]-6-phenylbenzonitrile;

2-(3,5-dimethoxy-4-{[(pyridin-3-ylmethyl)amino]methyl}phenoxymethyl)-6-phenylbenzonitrile;

2-(3,5-dimethoxy-4-{[(pyridin-4-ylmethyl)amino]methyl}phenoxymethyl)-6-phenylbenzonitrile;

2-[4-({[(3-hydroxyphenyl)methyl]amino}methyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-[4-({[(2-hydroxyphenyl)methyl]amino}methyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-[4-({[(4-hydroxyphenyl)methyl]amino}methyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-{4-[(cyclobutylamino)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-{4-[(cyclopentylamino)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-{4-[(cyclohexylamino)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-[3,5-dimethoxy-4-({[3-(2-oxopyrrolidin-1-yl)propyl]amino}methyl)phenoxymethyl]-6-phenylbenzonitrile;

2-(3,5-dimethoxy-4-{[(propan-2-yl)amino]methyl}phenoxymethyl)-6-phenylbenzonitrile;

N-{2-[({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)amino]ethyl}acetamide;

2-[4-({[2-(dimethylamino)ethyl]amino}methyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-(3,5-dimethoxy-4-{[(2-methoxyethyl)amino]methyl}phenoxymethyl)-6-phenylbenzonitrile;

2-(4-{[(2-hydroxyethyl)amino]methyl}-3,5-dimethoxyphenoxymethyl)-6-phenylbenzonitrile;

2-[4-({[1-(hydroxymethyl)cyclopentyl]amino}methyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-(4-{[(4-hydroxycyclohexyl)amino]methyl}-3,5-dimethoxyphenoxymethyl)-6-phenylbenzonitrile;

3-[({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)amino]propanamide;

2-{3,5-dimethoxy-4-[(methylamino)methyl]phenoxymethyl}-6-phenylbenzonitrile;

2-[3,5-dimethoxy-4-({[2-(pyridin-2-yl)ethyl]amino}methyl)phenoxymethyl]-6-phenylbenzonitrile;

2-{3,5-dimethoxy-4-[(2-methylpyrrolidin-1-yl)methyl]phenoxymethyl}-6-phenylbenzonitrile;

2-{4-[(4-acetylpiperazin-1-yl)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-[3,5-dimethoxy-4-(pyrrolidin-1-ylmethyl)phenoxymethyl]-6-phenylbenzonitrile;

2-(4-{[3-(hydroxymethyl)piperidin-1-yl]methyl}-3,5-dimethoxyphenoxymethyl)-6-phenylbenzonitrile;

N-[(3S)-1-({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)pyrrolidin-3-yl]acetamide;

2-[4-(azetidin-1-ylmethyl)-3,5-dimethoxyphenoxymethyl]-6-phenylbenzonitrile;

2-{4-[(4-acetyl-1,4-diazepan-1-yl)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-(4-{[ethyl(pyridin-4-ylmethyl)amino]methyl}-3,5-dimethoxyphenoxymethyl)-6-phenylbenzonitrile;

2-(4-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dimethoxyphenoxymethyl)-6-phenylbenzonitrile;

2-{4-[(2, 5-dimethylpyrrolidin-1-yl)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

2-{4-[(3-hydroxypiperidin-1-yl)methyl]-3,5-dimethoxyphenoxymethyl}-6-phenylbenzonitrile;

1-({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)piperidine-3-carboxylic acid;

(2S)-1-({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)pyrrolidine-2-carboxamide;

(2S)-1-({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)piperidine-2-carboxylic acid;

(6 S)-5-({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-1,2,5-triazaspiro[2.4]hept-1-ene-6-carboxylic acid;

{2-[2-(2-aminoethoxy)ethoxy]ethyl}({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amine;

2-(2-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethoxy}ethoxy)ethan-1-ol;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)({2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl})amine;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)({2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl})amine;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)({2-[4-(pyrimidin-2-yl)piperazin-1-yl]ethyl})amine;

tert-butyl 4-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}piperazine-1-carboxylate;

4-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}-1λ 6 ,4-thiomorpholine-1,1-dione;

benzyl N-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}carbamate;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[3-(4-methylpiperazin-1-yl)propyl]amine;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[3-(morpholin-4-yl)propyl]amine;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[3-(1H-imidazol-1-yl)propyl]amine;

4-{[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}azetidin-2-one;

3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-N-[2-(1H-imidazol-4-yl)ethyl]propanamide;

2-({3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propyl}(2-hydroxyethyl)amino)ethan-1-ol;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(3-phenoxypropyl)amine;

4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-hydroxybutanoic acid;

3-(4-{3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propyl}piperazin-1-yl)phenol;

[2-(benzyloxy)ethyl]({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amine;

1-{2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}-5,8,11-trioxa-2-azatridecan-13-ol;

1-{2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}-5,8,11,14,17,20-hexaoxa-2-azatricosan-23-oic acid;

1-{2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}-5,8,11,14-tetraoxa-2-azaheptadecan-17-oic acid;

(2S)-5-carbamimidamido-2-[(2R)-2-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]acetamido}-3-phenylpropanamido]pentanoic acid;

2-(2-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]acetamido}acetamido)acetic acid;

(2S)-5-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-acetamidopentanoic acid;

[(3,3-difluorocyclobutyl)methyl]({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amine;

(cyclobutylmethyl)({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amine;

(2S)-2-(2-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]acetamido}acetamido)-4-methylpentanoic acid;

(2-aminoethyl)({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)methylamine;

3-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(methyl)amino]ethyl}-1-phenylurea;

N-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(methyl)amino]ethyl}-2-oxo-2H-chromene-6-sulfonamide;

N-{2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(methyl)amino]ethyl}prop-2-enamide;

ethyl (2E)-3-({2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)(methyl)amino]ethyl}carbamoyl)prop-2-enoate;

(6 S)-5-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-1,2,5-triazaspiro[2.4]hept-1-ene-6-carboxylic acid;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-(hydroxymethyl)propane-1,3-diol;

(3S)-4-[({3-chloro-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

N-{2-[({3-cyano-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethyl}acetamide;

N-(2-{[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2,5-difluorophenyl)methyl]amino}ethyl)acetamide;

(3S)-4-{[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2, 5-difluorophenyl)methyl]amino}-3-hydroxybutanoic acid;

(2S)-1-[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2, 5-difluorophenyl)methyl]piperidine-2-carboxylic acid;

N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl) methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide;

5-(azetidin-1-ylmethyl)-2-[(2-methyl-3-phenylphenyl)methoxy]pyridine;

N-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)cyclobutanamine;

N-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)cyclopentanamine;

1-{3-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]propyl}pyrrolidin-2-one;

({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)[2-(pyridin-2-yl)ethyl]amine;

2-[(2-methyl-3-phenylphenyl)methoxy]-5-(pyrrolidin-1-ylmethyl)pyridine;

[(2S)-1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)pyrrolidin-2-yl]methanol;

(2S)-1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)piperidine-2-carboxylic acid;

1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)piperidine-3-carboxylic acid;

[1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)piperidin-3-yl]methanol;

1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)piperidin-4-ol;

2-[(2-methyl-3-phenylphenyl)methoxy]-5-[(2-methylpyrrolidin-1-yl)methyl]pyridine;

({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)(propan-2-yl)amine;

methyl({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amine;

N-{2-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide;

[2-(dimethylamino)ethyl]({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amine;

(2-methoxyethyl)({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amine;

2-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethan-1-ol;

{1-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]cyclopentyl}methanol;

4-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]cyclohexan-1-ol;

3-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]propanamide;

(2S)-2-[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]propanoic acid;

5-{[({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]methyl}pyrrolidin-2-one;

N-[(3S)-1-({6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)pyrrolidin-3-yl]acetamide;

(2R)-2-{[(4-{[3-(3-fluoro-5-methoxyphenyl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}propanoic acid;

(2R)-2-{[(4-{[3-(2H-1,3-benzodioxol-5-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}propanoic acid;

3-[3-(4-{[(2-hydroxyethyl)amino]methyl}-3,5-dimethoxyphenoxymethyl)-2-methylphenyl]phenol;

2-{[(4-{[3-(2H-1,3-benzodioxol-5-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}ethan-1-ol;

2-{[(4-{[3-(3-ethoxyphenyl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}ethan-1-ol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-{3-[2-(piperidin-1-yl)ethoxy]phenyl}phenyl)methoxy]phenyl}methyl)amino]ethan-1-ol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-methylpropane-1,3-diol;

(2S,3S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-methylpentan-1-ol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-4-methylpentan-1-ol;

1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propan-2-ol;

{1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclopentyl}methanol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propane-1,3-diol;

1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butan-2-ol;

(2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-4-methylpentan-1-ol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-methylbutan-1-ol;

(2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-methylbutan-1-ol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propan-1-ol;

(2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butan-1-ol;

2-{[(2,6-dimethoxy-4-{[2-methyl-3-(3-propoxyphenyl)phenyl]methoxy}phenyl)methyl]amino}ethan-1-ol;

(2S)-3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propane-1,2-diol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-methylbutanoic acid;

1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-methylpropan-2-ol;

(2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]pentan-1-ol;

3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butan-2-ol;

(2R)-3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propane-1,2-diol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butan-1-ol;

(2S)-1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]propan-2-ol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclohexan-1-ol;

(1S,2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclohexan-1-ol;

(3R,4S)-4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]oxolan-3-ol;

1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-methylbutan-2-ol;

({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)[3-(dimethylamino)-2-hydroxypropyl]amine;

(2R)-2-cyclopropyl-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethan-1-ol;

3-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-methylbutan-2-ol;

(2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-phenylethan-1-ol;

1-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2,3-dihydro-1H-inden-2-ol;

(1S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-phenylethan-1-ol;

(3S)-4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]thiolan-3-ol;

(1R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-phenylethan-1-ol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-(pyridin-3-yl)ethan-1-ol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-(pyridin-4-yl)ethan-1-ol;

(2S)-2-cyclohexyl-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]ethan-1-ol;

{4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]oxan-4-yl}methanol;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-1-(1-methyl-1H-imidazol-2-yl)ethan-1-ol;

1-{[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}cyclohexan-1-ol;

(1R,2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclopentan-1-ol;

4-{[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}-1-methylpiperidin-4-ol;

(1R,2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclohexan-1-ol;

(1S,2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclopentan-1-ol;

(1R,2R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]cyclopentan-1-ol;

(2R,3S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butane-1,3-diol;

(2S,3R)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]butane-1,3-diol;

1-{[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]methyl}cyclobutan-1-ol;

(3R)-4-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-3-hydroxybutanoic acid;

2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-ethylpropane-1,3-diol;

(2S)-2-[({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)amino]-2-phenylethan-1-ol;

1-({2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl}methyl)-4-hydroxypiperidine-4-carboxamide;

N-(2-{[(2,6-dimethoxy-4-{[3-(3-methoxyphenyl)-2-methylphenyl]methoxy}phenyl)methyl]amino}ethyl)acetamide;

N-(2-{[(4-{[3-(3-ethoxyphenyl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}ethyl)acetamide;

N-(2-{[(4-{[3-(2H-1,3-benzodioxol-5-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}ethyl)acetamide;

[(4-{[3-(2H-1,3-benzodioxol-5-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl][2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

N-(2-{[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl]amino}ethyl)acetamide;

[(4-{[3-(3-ethoxyphenyl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl][2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

[(4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2,6-dimethoxyphenyl)methyl][2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

{[2,6-dimethoxy-4-({3-[3-(methoxymethoxy)phenyl]-2-methylphenyl}methoxy)phenyl]methyl}[2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

{[2,6-dimethoxy-4-({2-methyl-3-[3-(prop-2-en-1-yloxy)phenyl]phenyl}methoxy)phenyl]methyl}[2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

{[4-({3-[2-fluoro-5-(2-methoxyethoxy)phenyl]-2-methylphenyl}methoxy)-2,6-dimethoxyphenyl]methyl}[2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl]amine;

(3S)-4-[({4-[(2-cyano-3-phenylphenyl)methoxy]-2,6-dimethoxyphenyl}methyl)amino]-3-hydroxybutanoic acid;

(3S)-3-hydroxy-4-[({5-[(2-methyl-3-phenylphenyl)methoxy]pyridin-2-yl}methyl)amino]butanoic acid; and

N-(2-{[(3-chloro-4-{[2-methyl-3-(thiophen-3-yl)phenyl]methoxy}phenyl)methyl]amino}ethyl)acetamid.

9. The compound according to claim 1 or salts thereof, wherein Ring A is:

10. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

11. A method of treating a disease or disorder associated with the inhibition of the PD-1/PD-L1 interaction, wherein said disease or disorder is a cancer selected from the group consisting of melanoma, renal cancer, prostate cancer, breast cancer, colon cancer, lung cancer, bone cancer, pancreatic cancer, skin cancer, head and neck cancer, uterine cancer, bladder cancer, ovarian cancer, brain cancer, kidney cancer, colon cancer, rectal cancer, stomach cancer, testicular cancer, Hodgkin's lymphoma, acute myeloid leukemia, chronic myeloid leukemia, myeloma, small intestine cancer, squamous cell cancer; or a virological infection selected from the group consisting of HPV, HBV, HCV, KHSV and HIV infections, the method comprising administering to a mammalian patient a compound according to claim 1 or a pharmaceutically acceptable salt.