IP Library Granted Patent US 9,888,971
Granted Patent B2
US 9,888,971 · App. 14/987,107 · Granted Feb 13, 2018

Method and system for image processing to determine patient-specific blood flow characteristics

Inventor: Charles A. Taylor (Menlo Park, CA)
Assignee: HEARTFLOW, INC.
A61B34/10A61B5/004A61B5/0035A61B5/0044A61B5/02A61B5/021A61B5/024A61B5/026A61B5/02007A61B5/029A61B5/02028A61B5/0263A61B5/055A61B5/1075A61B5/1118A61B5/22A61B5/4848A61B5/6852A61B5/7246A61B5/7275A61B5/7278A61B5/745A61B6/03A61B6/032A61B6/481A61B6/503A61B6/504A61B6/507A61B6/5205A61B6/5217A61B6/5229A61B8/02A61B8/04A61B8/06A61B8/065A61B8/481A61B8/5223A61B8/5261A61B34/25A61M5/007G01R33/5601G01R33/5635G01R33/56366G06F17/10G06F17/5009G06F17/5018G06F19/12G06F19/26G06F19/321G06F19/322G06F19/324G06F19/3431G06F19/3437G06G7/60G06K9/00147G06K9/46G06K9/4604G06K9/52G06K9/6215G06K9/6267G06K9/6298G06T7/0012G06T7/0014G06T7/11G06T7/12G06T7/13G06T7/149G06T7/20G06T7/60G06T7/62G06T7/70G06T7/73G06T7/74G06T11/00G06T11/001G06T11/008G06T11/20G06T11/60G06T15/10G06T17/00G06T17/005G06T17/20A61B2034/104A61B2034/105A61B2034/107A61B2034/108A61B2090/374A61B2090/3762A61B2090/3764A61B2576/00A61B2576/023G06K2009/4666G06T2200/04G06T2207/10012G06T2207/10072G06T2207/10081G06T2207/10088G06T2207/10104G06T2207/10108G06T2207/20036G06T2207/20124G06T2207/30048G06T2207/30104G06T2210/41G06T2211/404
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Quick Facts
Patent No.
US 9,888,971
App. No.
14/987,107
Filed
Jan 4, 2016
Granted
Feb 13, 2018
Kind
B2
Art Unit
2667
USPC
382/128
Abstract

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Claims (25)

1. A system for medical image processing, the system comprising:

a data storage device storing instructions for medical image processing; and

a processor configured to execute the instructions to perform a method including:

receiving one or more non-invasively produced images of at least a blood vessel of a patient;

segmenting the images to identify an ischemic region of interest of the blood vessel and generating a three-dimensional geometric model of the identified ischemic region of interest of the blood vessel;

identifying a vessel region of interest in the identified ischemic region of interest;

identifying a stenosis in the vessel region of interest based on a pressure index computed using a first simulation of blood flow through the geometric model of the blood vessel;

determining a connection position to connect a bypass vessel that diverts blood flow around the identified stenosis, wherein the connection position is determined using a subsequent simulation of blood flow; and

displaying the determined connection position on a display.

2. The system of claim 1 , wherein the determining step comprises determining the connection position using the pressure index in the vessel of interest.

3. The system of claim 2 , wherein the determining step comprises determining a drop level of the pressure index.

4. The system of claim 3 , wherein the determining step comprises determining the connection position using a measurement of the interior of the vessel of interest.

5. The system of claim 3 , wherein the determining step comprises determining an elasticity of the vessel of interest.

6. The system of claim 2 , wherein the determining step comprises determining the connection position using a measurement of the interior of the vessel of interest.

7. The system of claim 1 , wherein the displaying step comprises displaying, on the display, a first graph representing the pressure index corresponding to the connection.

8. The system of claim 7 , wherein the displaying step comprises displaying the first graph with an image in which the connection position is visualized.

9. The system of claim 1 , wherein the determining step comprises calculating a degree of fitness when the bypass vessel is connected to a predetermined portion of the blood vessel, and wherein the displaying step comprises displaying a distribution of the degree of fitness at the predetermined portion on the display.

10. The system of claim 1 , wherein the pressure index comprises a myocardial fractional flow reserve.

11. A method of processing medical images, comprising:

receiving one or more non-invasively produced images of at least a blood vessel of a patient;

segmenting the images to identify an ischemic region of interest of the blood vessel and generating a three-dimensional geometric model in a plurality of phases region of the identified ischemic region of interest of the blood vessel;

identifying a vessel region of interest in the identified ischemic region of interest;

identifying a stenosis in the vessel region of interest based on a pressure index computed using a first simulation of blood flow through the geometric model of the blood vessel;

determining a connection position to connect a bypass vessel that diverts blood flow around the identified stenosis, wherein the connection position is determined using a subsequent simulation of blood flow; and

displaying the determined connection position on a display.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Sep 11, 2025
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 072876/0775 →
RELEASE OF SECURITY INTEREST Recorded Jun 21, 2024
From: HAYFIN SERVICES LLP
To: HEARTFLOW, INC.
Reel/Frame 067801/0032 →
SECURITY INTEREST Recorded Jun 18, 2024
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 067775/0966 →
SECURITY INTEREST Recorded Jan 20, 2021
From: HEARTFLOW, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 055037/0890 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2016
From: TAYLOR, CHARLES A.
To: HEARTFLOW, INC.
Reel/Frame 037437/0786 →
Continuity (10)
Continuation 14276442 · May 13, 2014
Continuation 13658739 · Oct 23, 2012
Continuation 13014835 · Jan 27, 2011
Division 13013561 · Jan 25, 2011
Provisional Application 61401462 · Aug 12, 2010
Provisional Application 61401915 · Aug 20, 2010
Provisional Application 61402308 · Aug 26, 2010
Provisional Application 61402345 · Aug 27, 2010
Provisional Application 61404429 · Oct 1, 2010
Related Publication 20160117819A1 · Apr 28, 2016