Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.
1. A method for regulating Tie-2 receptor activation in a subject in need thereof, comprising administering to the subject a therapeutically-effective amount of a humanized form of R15E6 that activates the Tie-2 receptor, wherein administration of the humanized form of R15E6 to the subject activates the Tie-2 receptor in the presence of Ang1.
2. The method of claim 1 , wherein the humanized form of R15E6 does not bind the Tie-2 receptor.
3. The method of claim 1 , wherein administration of the humanized form of R15E6 to the subject enhances VEGF-mediated endothelial cell survival in a dose dependent manner.
4. The method of claim 3 , wherein administration of the humanized form of R15E6 to the subject enhances FGF-mediated endothelial cell survival in a dose dependent manner.
5. The method of claim 1 , wherein administration of the humanized form of R15E6 to the subject activates the Tie-2 receptor in the presence of Ang1 to a greater degree than in the absence of Ang1.
6. A method of enhancing Tie-2 receptor phosphorylation in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a humanized form of R15E6, wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 activation.
7. The method of claim 6 , wherein the humanized form of R15E6 does not bind the Tie-2 receptor.
8. The method of claim 6 , wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 receptor phosphorylation in the presence of VEGF.
9. The method of claim 8 , wherein the humanized form of R15E6 enhances Ang1-induced Tie-2 receptor phosphorylation in the presence of FGF.
10. The method of claim 1 , wherein the humanized form of R15E6 binds to SEQ ID NO: 3.
11. The method of claim 6 , wherein the humanized form of R15E6 binds to SEQ ID NO: 3.