N-phenyl and N-benzyl enaminones and methods for using same
The present disclosure provides compounds, compositions, and methods for use of the compounds. The compounds are N-phenyl or N-benzyl enaminones. The compositions can be pharmaceutical compositions. For example, the compounds/compositions are used in treating seizure disorders. The methods entail administering a composition comprising one or more of the compounds to a subject in need thereof. Articles of manufacture comprising one or more of the compounds/compositions are also provided.
1. A compound having the following structure:
2. The compound of claim 1 , wherein the compound has the following structure:
3. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
4. A method for treating a seizure in an individual in need thereof comprising administering to the individual a composition comprising a therapeutically effective amount of a compound of claim 1 .
5. The method of claim 4 , wherein the seizure is an epileptic seizure.
6. The method of claim 4 , wherein the seizure is a partial seizure.
7. The method of claim 4 , wherein the seizure is a generalized seizure.
8. The method of claim 4 , wherein the individual in need has previously experienced an epileptic seizure.
9. An article of manufacture comprising packaging and at least one container, wherein the container contains a composition comprising a compound of claim 1 , the article further comprising printed material, the printed material providing an indication that the composition is for use in treatment of a seizure disorder.
10. The article of claim 9 , wherein the seizure disorder is epilepsy.
11. The article of claim 9 , wherein the seizure disorder comprises partial seizures.
12. The article of claim 9 , wherein the seizure disorder comprises generalized seizures.
13. The compound of claim 1 , wherein the compound is active in at least in therapy resistance psychomotor (6-Hz) model.