IP Library Granted Patent US 9,953,137
Granted Patent B2
US 9,953,137 · App. 13/935,371 · Granted Apr 24, 2018

Healthcare analysis stream management

Inventor: Patrick Soon-Shiong (Los Angeles, CA)
Assignee: Nant Holdings IP, LLC
G06F19/322G06F19/18G06F19/22G06F19/28G06F19/321G06F19/324H04L67/10H04L67/42
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Quick Facts
Patent No.
US 9,953,137
App. No.
13/935,371
Granted
Apr 24, 2018
Kind
B2
Abstract

Apparatus, systems and methods for pre-processing, analyzing, and storing genomic data through a scalable, distributed analysis system across a network is presented.

Claims (38)

1. A genomic analysis system comprising:

a plurality of sequencing devices configured to pre-process sequence data to generate pre-processed sequence data, the pre-processed sequence data comprising the sequence data and annotations, the annotations comprising alignment data between the sequence data and a pre-existing genome database;

a sequencing device interface configured to acquire pre-processed sequence data from the plurality of sequencing devices, where the sequence data is from a plurality of patients;

an analysis network; and

a plurality of analysis nodes interconnected via the analysis network forming a genomic analysis engine having patient-specific analysis network topologies coupled with the sequencing device interface, and configured to, based on the pre-processed sequence data, process the sequence data from the patients in parallel into patient-specific genome data according to processing routes of the patient-specific analysis network topologies.

2. The system of claim 1 , wherein the analysis engine is configured to process sequence data from at least 100 patients in parallel.

3. The system of claim 1 , wherein the analysis engine is configured to process sequence data into the genome data at a rate of at least X patients per Y unit of time, where X is at least 3 and Y is at most one day.

4. The system of claim 3 , wherein X is 100 and Y is one day.

5. The system of claim 3 , wherein X is 100 and Y is one hour.

6. The system of claim 1 , wherein the analysis network comprises an optic fiber data link.

7. The system of claim 1 , wherein the sequencing device interface is configured to obtain the sequence data from at least 5 sequencing devices in parallel.

8. The system of claim 7 , wherein the sequencing device interface is configured to obtain the sequence data from at least 10 sequencing devices in parallel.

9. The system of claim 1 , wherein the genome data comprises genomic data of the patients individually.

10. The system of claim 1 , wherein the analysis engine is configured to generate a notification as a function of the genome data.

11. The system of claim 10 , wherein the notification comprises a request to obtain a higher confidence level with respect to the sequenced data.

12. The system of claim 10 , wherein the notification configures a route within the analysis network.

13. The system of claim 1 , wherein the analysis engine is configured to establish processing routes among the analysis nodes according to which at least one of the sequenced data and genome data is routed.

14. The system of claim 13 , wherein the processing routes are established as a function of a priority.

15. The system of claim 1 , wherein the analysis nodes are configured to exchange at least some of the sequence data and the genome data.

16. The system of claim 1 , wherein the analysis nodes comprise network switches.

17. The system of claim 1 , wherein the analysis nodes comprise high performance computing facilities.

18. The system of claim 17 , wherein the analysis nodes comprise at least five high performance computing facilities.

19. The system of claim 1 , wherein the analysis engine processes the sequence data to generate the genome data as a function of a normalized genomic sequence.

20. The system of claim 19 , wherein the normalized genomic sequence comprises a statistical compilation from a population of patients.

21. The system of claim 19 , wherein the genome data comprises at least one of the following with respect to the normalized genomic sequence: a hot spot, a weighted reference point, and a prioritization for analysis.

22. The system of claim 1 , further comprising a management interface configured to allow a user to provide feedback to the sequencing device via the sequencing device interface.

23. The system of claim 22 , wherein the feedback includes sequencing device instructions.

24. The system of claim 23 , wherein the sequencing device instructions include at least one of the following: repeat sequencing target sequence area, halt sequencing, start sequencing, send data upon satisfaction of a trigger, delete sequence data from sequencing device, licensing management instructions, prioritizing sequence events, forwarding instructions of sequence data, and scheduling sequencing.

25. The system of claim 22 , wherein the user comprises at least one of the following: an analysis node, a healthcare provider, a researcher, a sequencing device manager, an analysis system manager, and a patient.

26. The system of claim 1 , wherein the sequencing device interface is configured to acquire sequence data through an image recognition algorithm applied to image data representing the sequence data.

27. The system of claim 1 , wherein the analysis engine is configured to acquire sequence data through an image recognition algorithm applied to image data representing the sequence data.

28. The system of claim 1 , the annotations further comprising data identifying a putative or actual sequence location in a genome.

29. The system of claim 1 , the annotations further comprising an order of analysis of genes.

30. A genomic analysis system comprising:

a plurality of sequencing devices configured to pre-process sequence data to generate pre-processed sequence, the pre-processed sequence data comprising the sequence data and annotations, the annotations comprising a diagnostic code;

a sequencing device interface configured to acquire pre-processed sequence data from the plurality of sequencing devices, where the sequence data is from a plurality of patients;

an analysis network; and

a plurality of analysis nodes interconnected via the analysis network forming a genomic analysis engine having patient-specific analysis network topologies coupled with the sequencing device interface, and configured to, based on the pre-processed sequence data, process the sequence data from the patients in parallel into patient-specific genome data according to processing routes of the patient-specific analysis network topologies.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2016
From: SOON-SHIONG, PATRICK
To: NANT HOLDINGS IP, LLC
Reel/Frame 037614/0665 →
Continuity (6)
Provisional Application 61668941 · Jul 6, 2012
Provisional Application 61673943 · Jul 20, 2012
Provisional Application 61842316 · Jul 2, 2013
Provisional Application 61842323 · Jul 2, 2013
Provisional Application 61842325 · Jul 2, 2013
Related Publication 20140012843A1 · Jan 9, 2014