Granted Patent B2

US 9,958,521 · App. 15/089,571 · Granted May 1, 2018

Inventors: Jeffrey Howard Kaditz (San Francisco, CA); Andrew Gettings Stevens (New York, NY)

Assignee: Q Bio, Inc.

G01R33/48G01N24/08G01R33/448G01R33/465G01R33/4804G01R33/56358

Abstract

Claims (56)

1. A system to determine an invariant magnetic-resonance (MR) signature of a biological sample, comprising:

an MR scanner configured to perform MR scans of the biological sample;

an interface circuit, electrically coupled to the MR scanner, configured to communicate information with the MR scanner;

a processor electrically coupled to the MR scanner; and

memory, electrically coupled to the processor, storing a program module, wherein, when executed by the processor, the program module causes the system to perform the MR scans of the biological sample by performing one or more operations comprising:

providing, to the MR scanner, scanning instructions to capture MR signals of one or more types of nuclei in the biological sample, wherein the MR signals are associated with voxels at three-dimensional (3D) positions in the biological sample, and wherein the scanning instructions include at least a magnetic-field strength and a pulse sequence to be applied to the biological sample; and

receiving, from the MR scanner, the MR signals;

determining an MR model of the voxels in the biological sample based on the MR signals and the scanning instructions, wherein the MR model is based at least in part on model parameters, a simulation technique and predetermined characteristics of the MR scanner, including magnetic-field inhomogeneity and noise characteristics, and wherein determining the MR model involves:

generating simulated MR signals for the biological sample based on the MR model and the scanning instructions and

comparing the simulated MR signals and the MR signals to determine a difference vector;

iteratively modifying the scanning instructions based on the difference vector and repeating the providing, the receiving and the determining until a convergence criterion is achieved, wherein the modified scanning instructions include changes to at least one of the magnetic-field strength and the pulse sequence; and

storing, in the memory, an identifier of the biological sample and an invariant MR signature of the biological sample that corresponds to the MR model after the convergence criterion is achieved and that describes a dynamic MR response of the voxels in the biological sample at an arbitrary magnetic-field strength and with predetermined characteristics of an arbitrary MR scanner.

2. The system of claim 1 , wherein the identifier uniquely identifies the biological sample.

3. The system of claim 1 , wherein the one or more operations comprise generating the identifier.

4. The system of claim 1 , wherein the system further comprises a sample-information reader electrically coupled to the interface circuit; and

wherein the one or more operations comprise receiving, from the sample-information reader, information that specifies the identifier.

5. The system of claim 1 , wherein the system further comprises a measurement device, electrically coupled to the interface circuit, configured to measure a physical property of the biological sample;

wherein the one or more operations comprise:

receiving, from the measurement device, physical property information that specifies the measured physical property; and

storing, in the memory, the physical property information with the identifier and the invariant MR signature.

6. The system of claim 5 , wherein the physical property includes one of: a weight of the biological sample; one or more dimensions of the biological sample; an impedance of the biological sample; and an image of the biological sample.

7. The system of claim 6 , wherein the measurement device includes one of: an imaging sensor; a scale; an impedance analyzer; a laser imaging system; and a microscope.

8. The system of claim 1 , wherein the MR scanner includes a bore-type MR scanner having a bore diameter between 1 and 10 cm.

9. The system of claim 1 , wherein the MR scanner includes a bore-type MR scanner that is enclosed in a chamber, defined by a surface, filled with an inert gas.

10. The system of claim 1 , wherein the MR scanner includes a bore-type MR scanner that is enclosed in a chamber, defined by a surface, which is configured to have a pressure less than atmospheric pressure.

11. The system of claim 1 , wherein the biological sample is enclosed in a vessel that is filled with an inert gas.

12. The system of claim 1 , wherein the biological sample is enclosed in a vessel that has a pressure less than atmospheric pressure.

13. The system of claim 1 , wherein the one or more operations comprise encrypting the invariant MR signature prior to storage in the memory.

14. The system of claim 1 , wherein the biological sample is formalin fixed-paraffin embedded; and

wherein the one or more operations comprise transforming the invariant MR signature into an estimated invariant MR signature of an in-vivo sample based on the MR model.

15. The system of claim 1 , wherein the biological sample comprises an in-vivo sample.

16. The system of claim 1 , wherein the one or more operations comprise:

comparing the invariant MR signature to one or more predetermined invariant MR signatures;

determining a classification of the biological sample based on the comparisons; and

storing, in the memory, the determined classification with the identifier and the invariant MR signature.

17. The system of claim 1 , wherein the one or more operations comprise:

performing an additional MR measurement on the biological sample; and

storing, in the memory, a result of the additional MR measurement with the identifier and the invariant MR signature.

18. The system of claim 14 , wherein the additional MR measurement comprises one of: MR thermometry (MRT), MR spectroscopy (MRS), MR imaging, (MRI), magnetic-field relaxomety, and MR elastography (MRE).

19. A non-transitory computer-readable storage medium for use in conjunction with a magnetic-resonance (MR) scanner, the computer-readable storage medium storing a program module, wherein, when executed by the MR scanner, the program module causes the MR scanner to determine an MR signature of a biological sample by performing one or more operations comprising:

providing, to the MR scanner, scanning instructions to capture MR signals of one or more types of nuclei in the biological sample, wherein the MR signals are associated with voxels at three-dimensional (3D) positions in the biological sample, and wherein the scanning instructions include at least a magnetic-field strength and a pulse sequence to be applied to the biological sample; and

receiving, from the MR scanner, the MR signals;

determining an MR model of the voxels in the biological sample based on the MR signals and the scanning instructions, wherein the MR model is based at least in part on model parameters, a simulation technique and predetermined characteristics of the MR scanner, including magnetic-field inhomogeneity and noise characteristics, and wherein determining the MR model involves:

generating simulated MR signals for the biological sample based on the MR model and the scanning instructions and

comparing the simulated MR signals and the MR signals to determine a difference vector;

iteratively modifying the scanning instructions based on the difference vector and repeating the providing, the receiving and the determining until a convergence criterion is achieved, wherein the modified scanning instructions include changes to at least one of the magnetic-field strength and the pulse sequence; and

storing, in the memory, an identifier of the biological sample and an invariant MR signature of the biological sample that corresponds to the MR model after the convergence criterion is achieved and that describes a dynamic MR response of the voxels in the biological sample at an arbitrary magnetic-field strength and with predetermined characteristics of an arbitrary MR scanner.

20. A method for determining a magnetic-resonance (MR) signature of a biological sample using an MR scanner, the method comprising:

by a computer:

providing, to the MR scanner, scanning instructions to capture MR signals of one or more types of nuclei in the biological sample, wherein the MR signals are associated with voxels at three-dimensional (3D) positions in the biological sample, and wherein the scanning instructions include at least a magnetic-field strength and a pulse sequence to be applied to the biological sample; and

receiving, from the MR scanner, the MR signals;

determining an MR model of the voxels in the biological sample based on the MR signals and the scanning instructions, wherein the MR model is based at least in part on model parameters, a simulation technique and predetermined characteristics of the MR scanner, including magnetic-field inhomogeneity and noise characteristics, and wherein determining the MR model involves:

generating simulated MR signals for the biological sample based on the MR model and the scanning instructions and

comparing the simulated MR signals and the MR signals to determine a difference vector;

iteratively modifying the scanning instructions based on the difference vector and repeating the providing, the receiving and the determining until a convergence criterion is achieved, wherein the modified scanning instructions include changes to at least one of the magnetic-field strength and the pulse sequence; and

storing, in the memory, an identifier of the biological sample and an invariant MR signature of the biological sample that corresponds to the MR model after the convergence criterion is achieved and that describes a dynamic MR response of the voxels in the biological sample at an arbitrary magnetic-field strength and with predetermined characteristics of an arbitrary MR scanner.

Assignments (2)

Continuity (9)