IP Library › Granted Patent US 9,975,962
Granted Patent B2
US 9,975,962 · App. 14/389,219 · Granted May 22, 2018

Thrombin/plasmin-regulated antibodies that bind TFPI

Inventors: Zhuozhi Wang (Millbrae, CA); Ruth Winter (Oakland, CA); John Murphy (Berkeley, CA)
Assignee: BAYER HEALTHCARE LLC
C07K16/38C07K14/745C07K16/36A61K39/3955C07K2317/55C07K2317/76C07K2317/92
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Quick Facts
Patent No.
US 9,975,962
App. No.
14/389,219
Granted
May 22, 2018
Kind
B2
Abstract

This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.

Claims (4)

1. A protease-regulated antibody which specifically binds to tissue factor pathway inhibitor (TFPI), comprising:

(a) the amino acid sequence of SEQ ID NO: 131 which comprises the variable light domain and constant light domain of the protease-regulated antibody and the protease cleavage site of SEQ ID NO: 137; and

(b) the amino acid sequence of SEQ ID NO: 133 which comprises the variable heavy domain and constant heavy domain of the protease-regulated antibody and the protease cleavage site of SEQ ID NO: 137,

wherein the protease-regulated antibody binds TFPI and promotes the generation of thrombin or plasmin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 2, 2014
From: WANG, ZHUOZHI; WINTER, RUTH; MURPHY, JOHN
To: BAYER HEALTHCARE LLC
Reel/Frame 033874/0824 →
Continuity (2)
Provisional Application 61617837 · Mar 30, 2012
Related Publication 20150064169A1 · Mar 5, 2015