Injectable drug delivery arrangement with controlled delivery cannula position relative to point of delivery

1. A method of delivering a medicine to a target location, the method comprising:

positioning a distal end of a cannula for insertion into a first tissue, the cannula including a steel tube defining a proximal end and the distal end of the cannula and a nodule welded along an outer circumferential surface of the steel tube and spaced at a defined distance from the distal end, the steel tube having a constant circular cross-section defining a circumference and a lumen extending between the proximal and distal ends, said nodule extending less than about the entire circumference of the tube,

inserting the distal end of the cannula into the first tissue,

advancing a portion of the tube through the first tissue,

penetrating the nodule through the first tissue while advancing the tube through the first tissue,

continuing to advance the tube through the first tissue to position the distal end of the cannula for insertion into the target location,

inserting the distal end of the cannula into the target location, a depth of insertion into the target location limited by the nodule, and

delivering the medicine to the target location through the lumen.

2. The method of claim 1 wherein inserting the distal end of the cannula into the target location includes advancing the distal end into the target location until the nodule is disposed adjacent the target location.

3. The method of claim 1 further including removing the distal end of the cannula from the target location and the first tissue.

4. The method of claim 1 wherein inserting the distal end of the cannula into the first tissue, advancing the portion of the tube through the first tissue, penetrating the nodule through the first tissue while advancing the tube through the first tissue, continuing to advance the tube through the first tissue to position the distal end of the cannula for insertion into the target location, and inserting the distal end of the cannula into the target location include movement of the tube in an axial direction of the cannula relative to at least one of the first tissue and the target location.

5. The method of claim 1 wherein inserting the distal end of the cannula into the target location includes inserting the distal end of the cannula into at least one of a tissue or bone.

6. The method of claim 1 wherein the delivering the medicine includes pumping the medicine from a pump.

7. The method of claim 6 wherein pumping the medicine includes manually activating the pump to deliver the medicine.

8. The method of claim 6 further including fluidly coupling at least one of a secondary cannula and tubing between the cannula and the pump.

9. The method of claim 1 further including controlling flow through the lumen with a control clamp.

10. The method of claim 1 wherein the delivering the medicine includes fluidly coupling a syringe and the cannula, and operating the syringe to deliver medicine through the lumen.

11. The method of claim 1 wherein positioning the distal end of the cannula for insertion into the first tissue includes advancing the distal end through an ear canal for insertion into a tympanic membrane, inserting the distal end of the cannula into the first tissue includes inserting the distal end into the tympanic membrane, advancing the portion of the tube through the first tissue includes advancing the portion through the tympanic membrane, and penetrating the nodule through the first tissue while advancing the tube through the first tissue includes penetrating the nodule through the tympanic membrane while advancing the tube through the tympanic membrane.

12. The method of claim 11 wherein continuing to advance the tube through the first tissue to position the distal end of the cannula for insertion into the target location includes continuing to advance the tube through the tympanic membrane to position the distal end of the cannula for insertion into an inner ear target location, inserting the distal end of the cannula into the target location includes inserting the distal end of the cannula into the inner ear target location, and delivering the medicine to the target location through the lumen includes delivering the medicine to the inner ear target location through the lumen.

13. The method of claim 12 wherein the inner ear target location includes at least one of a membrane, a bone, and a temporal bone lining the inner ear.

14. A method of delivering a medicine to an inner ear, the method comprising:

advancing a distal end of a cannula through an ear canal, the cannula including a tube defining a proximal end and the distal end of the cannula and a nodule along an outer circumferential surface of the tube and spaced at a defined distance from the distal end, the tube having a lumen extending between the proximal and distal ends, said nodule extending less than about an entire circumference of the tube,

positioning the distal end of the cannula for insertion into a tympanic membrane,

inserting the distal end of the cannula into the tympanic membrane,

advancing a portion of the tube through the tympanic membrane,

penetrating the nodule through the tympanic membrane while advancing the tube through the tympanic membrane,

continuing to advance the tube through the tympanic membrane to position the distal end of the cannula for insertion into an inner ear target location,

inserting the distal end of the cannula into the inner ear target location,

advancing the distal end into the inner ear target location until the nodule limits a depth of penetration into the inner ear target location, and

delivering the medicine to the inner ear target location through the lumen.

15. The method of claim 14 wherein the nodule abuts the inner ear target location to limit the depth of penetration.

16. The method of claim 14 wherein the inner ear target location includes at least one of a membrane, a bone, and a temporal bone lining the inner ear.

17. The method of claim 14 wherein the delivering the medicine includes pumping the medicine from a pump.