Inhibitors of deubiquitinating proteases
Disclosed are small molecule inhibitors of deubiquitinating enzymes (DUBs), and methods of using them. Certain compounds are selective for particular ubiquitin-specific proteases (USPs).
1. A compound selected from the group consisting of:
2. A method of treating a cancer, comprising the step of:
administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
wherein the cancer is leukemia, myeloma, lung cancer, colon cancer, central nervous system (CNS) cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, or breast cancer.
3. The method of claim 2 , wherein the cancer is leukemia or myeloma.
4. The method of claim 2 , wherein the compound is
5. The compound of claim 1 , wherein the compound is selected from the group consisting of:
6. The method of claim 2 , wherein the cancer is leukemia.
7. The method of claim 2 , wherein the cancer is myeloma.