Coated pelvic implant device and method
Implant systems and methods are provided to include a treatment material with a pelvic implant device. The pelvic implant device, such as an incontinence sling, can include the treatment coating combination of a material, such as Phosphorylcholine (PC), and an infection prevention material, such as InhibiZone® (IZ) technology. The treatment material can be coated onto, or impregnation or integrated with, polypropylene mesh in order to prevent infection and promote healing.
1. An implant device for treating a pelvic condition, comprising:
a mesh support portion adapted to support pelvic tissue, the mesh support portion including a treatment coating having a cured phosphorylcholine component and an antibiotic component including minocycline and rifampin, such that the phosphorylcholine component is greater than sixty percent of the treatment coating and the antibiotic component is less than forty percent of the treatment coating, wherein the antibiotic component is applied over the cured phosphorylcholine component using one or more alcohol-based solvents, the mesh support portion including a tapered end portion;
an anchoring portion; and
an extension portion constructed at least in part of a biodegradable material, the extension portion extending between the tapered end portion of the mesh support portion and the anchoring portion, the extension portion being devoid of the treatment coating.
2. The implant device of claim 1 , wherein the mesh support portion is constructed at least in part of a polypropylene material.
3. The implant device of claim 2 , wherein the polypropylene material is a large pore polypropylene material.
4. The implant device of claim 1 , wherein the extension portion is a first extension portion, the anchoring portion is a first anchoring portion, and the tapered end portion is a first tapered end portion, the mesh support portion including a second tapered end portion, the implant device further comprising:
a second extension portion extending from the second tapered end portion of the mesh support portion; and
a second anchoring portion extending from the second extension portion.
5. The implant device of claim 1 , wherein the treatment coating is applied only to the mesh support portion.
6. The implant device of claim 1 , wherein the mesh support portion is adapted to support tissue for treating urinary incontinence.
7. The implant device of claim 1 , wherein the mesh support portion is adapted to support tissue for treating fecal incontinence.
8. The implant device of claim 1 , wherein the mesh support portion is adapted to support tissue for treating vaginal prolapse.
9. The implant device of claim 1 , wherein at least the mesh support portion is constructed of a plurality of woven filament members to define a plurality of open pores.
10. The implant device of claim 1 , wherein at least the mesh support portion is formed from a generally planar unitary film material to include a plurality of open pores.
11. A method of treating incontinence in a patient, comprising:
providing a polypropylene mesh implant having a mesh support portion adapted to support pelvic tissue, an extension portion constructed at least in part of a biodegradable material, and an anchoring portion, the mesh support portion including a tapered end portion, the extension portion extending between the tapered portion of the mesh support portion and the anchoring portion, the mesh support portion including a treatment coating including a phosphorylcholine coating applied to at least a portion of the mesh support portion, an antibiotic coating including minocycline and rifampin applied over the phosphorylcholine coating after it is cured using one or more alcohol-based solvents, and water soluble salt, the extension portion being devoid of the treatment coating; and
immersing the mesh support portion in water to facilitate leaching-out of the water soluble salt to provide a micro-porous treatment coating, such that the phosphorylcholine coating is at least two-thirds of the treatment coating and the antibiotic coating is less than one-third of the treatment coating.
12. The method of claim 11 , wherein the extension portion is a first extension portion, the tapered end portion is a first tapered end portion, and the anchoring portion is a first anchoring portion, the mesh support portion including a second tapered end portion, wherein the polypropylene mesh implant includes a second extension portion extending from the second tapered end portion of the mesh support portion, and a second anchoring portion extending from the second extension portion.
13. The method of claim 11 , wherein the mesh support portion is constructed of a plurality of woven filament members to define a plurality of open pores.
14. The method of claim 11 , wherein the mesh support portion is formed from a generally planar unitary film material to include a plurality of open pores.