IP Library Granted Patent US 10,034,832
Granted Patent B2
US 10,034,832 · App. 15/431,242 · Granted Jul 31, 2018

Sublingual antidepressant lozenge

Inventors: Anthony H. Salce, Jr. (Naples, FL); William F. Greenwood (Fairfield, CT); Shivsankar Misir (Naples, FL)
Assignee: Synergistic Therapeutics, LLC
A61K9/0056A23G3/0053A23G3/364A61K9/2009A61K9/2013A61K31/135A23V2002/00
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Quick Facts
Patent No.
US 10,034,832
App. No.
15/431,242
Granted
Jul 31, 2018
Kind
B2
Abstract

Technologies are described for formulations and methods to produce sublingual antidepressant lozenges. The lozenges may comprise troche base and ketamine. The lozenges may comprise 0.35 weight percent to 0.65 weight percent ketamine. The methods may comprise placing troche base into a chamber. The methods may comprise applying heat to the chamber. The heat may be sufficient to melt the troche base in the chamber. The methods may comprise adding a first ingredient into the chamber. The first ingredient may include ketamine. The methods may comprise mixing the first ingredient into the melted troche base in the chamber to form a melted mixture. The methods may comprise pouring the melted mixture into a mold. The methods may comprise cooling the melted mixture in the mold to form the lozenge.

Claims (57)

1. An antidepressant lozenge comprising a troche base and 0.35 weight percent to 0.65 weight percent ketamine, wherein the antidepressant lozenge is a treatment for depression and anxiety.

2. The lozenge of claim 1 , further comprising 1.05 weight percent to 1.35 weight percent silica gel powder.

3. The lozenge of claim 1 , further comprising 1.2 weight percent to 1.55 weight percent citric acid powder.

4. The lozenge of claim 1 , further comprising 1.8 weight percent to 2.1 weight percent acacia powder.

5. The lozenge of claim 1 , further comprising:

1.05 weight percent to 1.35 weight percent silica gel powder;

1.2 weight percent to 1.55 weight percent citric acid powder; and

1.8 weight percent to 2.1 weight percent acacia powder.

6. The lozenge of claim 5 , comprising:

0.5 weight percent ketamine;

1.2 weight percent silica gel powder;

1.38 weight percent citric acid powder; and

1.98 weight percent acacia powder.

7. The lozenge of claim 5 , further comprising a liquid flavoring.

8. The lozenge of claim 1 , wherein the troche base includes a blend of polyethylene glycols.

9. The lozenge of claim 1 , wherein the ketamine includes ketamine hydrochloride powder.

10. A method to produce an antidepressant lozenge, the method comprising:

placing troche base into a chamber;

applying heat to the chamber sufficient to melt the troche base in the chamber;

adding a first ingredient into the chamber, wherein the first ingredient includes ketamine;

mixing the first ingredient into the melted troche base in the chamber to form a melted mixture;

pouring the melted mixture into a mold; and

cooling the melted mixture in the mold to form the antidepressant lozenge, wherein the antidepressant lozenge is a treatment for depression and anxiety.

11. The method of claim 10 , further comprising, prior to pouring the melted mixture into the mold:

adding a second ingredient to the chamber, wherein the second ingredient includes silica gel powder; and

mixing the second ingredient with the melted mixture in the chamber.

12. The method of claim 10 , further comprising, prior to pouring the melted mixture into the mold:

adding a second ingredient to the, wherein the second ingredient includes citric acid powder; and

mixing the second ingredient with the melted mixture in the chamber.

13. The method of claim 10 , further comprising, prior to pouring the melted mixture into the mold:

adding a second ingredient to the chamber, wherein the second ingredient includes acacia powder; and

mixing the second ingredient with the melted mixture in the chamber.

14. The method of claim 10 , further comprising, prior to pouring the melted mixture into the mold:

adding a second ingredient to the chamber, wherein the second ingredient includes silica gel powder;

mixing the second ingredient with the melted mixture in the chamber;

adding a third ingredient to the chamber, wherein the third ingredient includes citric acid powder;

mixing the third ingredient with the melted mixture in the chamber;

adding a fourth ingredient to the chamber, wherein the fourth ingredient includes acacia powder; and

mixing the fourth ingredient with the melted mixture in the chamber.

15. The method of claim 14 , further comprising, prior to pouring the melted mixture into the mold:

adding a liquid flavoring to the chamber; and

mixing the liquid flavoring with the melted mixture in the chamber.

16. The method of claim 15 , wherein:

the mold includes thirty uniformly sized cavities;

the troche base weighs 29.850 grams;

the ketamine weighs 0.150 grams;

the silica gel powder weighs 0.360 grams;

the citric acid powder weighs 0.414 grams;

the acacia powder weighs 0.594 grams; and

a quantity of the liquid flavor is 6.000 ml.

17. The method of claim 10 , wherein the ketamine includes ketamine hydrochloride powder.

18. An antidepressant lozenge comprising 0.995 grams of troche base and 0.005 grams of ketamine, wherein the antidepressant lozenge is a treatment for depression and anxiety.

19. The lozenge of claim 18 , wherein the troche base includes a blend of polyethylene glycols and the ketamine includes ketamine hydrochloride powder.

20. The lozenge of claim 18 , further comprising:

0.012 grams of silica gel powder;

00.0138 grams of citric acid powder; and

0.0198 grams of acacia powder.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 19, 2018
From: SALCE, ANTHONY H., JR.; GREENWOOD, WILLIAM F.; MISIR, SHIVSANKAR
To: SYNERGISTIC THERAPEUTICS, LLC
Reel/Frame 046131/0185 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2017
From: SALCE, ANTHONY H., JR.; GREENWOOD, WILLIAM F.; MISIR, SHIVSANKAR
To: SYNERGISTIC THERAPEUTICS, LLC
Reel/Frame 041241/0706 →
Continuity (2)
Provisional Application 62294590 · Feb 12, 2016
Related Publication 20170231906A1 · Aug 17, 2017
Cited By (4)
US 12,221,428 US 12,239,632 US 12,465,578 US 12,589,083