Neridronic acid for treating arthritis
Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions, such as arthritis.
1. A method of treating arthritis comprising parenterally administering, in a single dose or in divided doses, about 5 mg to about 500 mg of neridronic acid, in an acid form or a salt form, to a human being suffering from arthritis.
2. The method of claim 1 , wherein the human being has a pain intensity of: 6 or greater measured using the 0-10 numerical rating scale (NRS), or 6 cm or greater using the 10 cm visual analog scale (VAS).
3. The method of claim 1 , wherein the human being has a pain intensity of: 7 or greater measured using the 0-10 NRS, or 7 cm or greater using the 10 cm VAS.
4. The method of claim 1 , wherein the neridronic acid is parenterally administered in at least two divided doses of about 10 mg to about 250 mg per divided dose.
5. The method of claim 1 , wherein the neridronic acid is parenterally administered in at least two divided doses of about 5 mg to about 250 mg per divided dose.
6. The method of claim 5 , wherein the divided doses of the neridronic acid are parenterally administered at an interval of 2, 3, or 4 days.
7. The method of claim 6 , wherein each divided dose contains about 100 mg of the neridronic acid.
8. The method of claim 6 , wherein each divided dose contains about 50 mg to about 150 mg of the neridronic acid.
9. The method of claim 6 , wherein each divided dose contains about 150 mg to about 200 mg of the neridronic acid.
10. The method of claim 6 , wherein each divided dose contains about 200 mg to about 250 mg of the neridronic acid.
11. The method of claim 1 , wherein the neridronic acid is administered intravenously.
12. The method of claim 1 , wherein the neridronic acid is administered daily.
13. The method of claim 1 , wherein the neridronic acid is administered weekly.
14. The method of claim 1 , wherein the neridronic acid is administered monthly.
15. A method of treating arthritis comprising parenterally administering, in a single dose or in divided doses, about 200 mg to about 500 mg of neridronic acid, in an acid form or a salt form, to a human being suffering from arthritis.
16. The method of claim 15 , wherein the neridronic acid is parenterally administered in at least two divided doses.
17. The method of claim 16 , wherein the divided doses of the neridronic acid are parenterally administered at an interval of 2, 3, or 4 days.
18. The method of claim 16 , wherein each divided dose contains about 100 mg of the neridronic acid.
19. The method of claim 16 , wherein each divided dose contains about 50 mg to about 150 mg of the neridronic acid.
20. The method of claim 16 , wherein each divided dose contains about 150 mg to about 250 mg of the neridronic acid.
21. A method of treating arthritis comprising parenterally administering, in a single dose or in divided doses, about 150 mg to about 500 mg of neridronic acid, in an acid form or a salt form, to a human being suffering from arthritis.
22. The method of claim 21 , wherein the neridronic acid is parenterally administered in at least two divided doses.
23. The method of claim 22 , wherein the divided doses of the neridronic acid are parenterally administered at an interval of 2, 3, or 4 days.
24. The method of claim 22 , wherein each divided dose contains about 100 mg of the neridronic acid.
25. The method of claim 22 , wherein each divided dose contains about 50 mg to about 150 mg of the neridronic acid.
26. The method of claim 22 , wherein each divided dose contains about 150 mg to about 250 mg of the neridronic acid.
27. The method of claim 21 , wherein the patient experiences pain relief within about three months after the neridronic acid is administered.
28. The method of claim 21 , wherein the patient has a pain intensity of: 6 or greater measured using the 0-10 NRS, or 6 cm or greater using the 10 cm VAS.
29. The method of claim 21 , wherein the patient has a pain intensity of: 7 or greater measured using the 0-10 NRS, or 7 cm or greater using the 10 cm VAS.
30. The method of claim 21 , wherein the neridronic acid is administered daily.