Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
Uses of the protein cereblon as a predictor of clinical sensitivity to cancer, inflammatory diseases, and patient response to drug treatment.
1. An isolated antibody or antigen binding fragment thereof that immunospecifically binds to an epitope in CRBN, wherein the epitope has the amino acid sequence SEQ ID NO:1, and wherein the isolated antibody comprises
(i) a heavy chain having complementarity determining regions (CDRs) consisting of the amino acids of the CDRs of SEQ ID NO: 5 and a light chain having complementarity determining regions (CDRs) consisting of the amino acids of the CDRs of SEQ ID NO: 7; or
(ii) a heavy chain having complementarity determining regions (CDRs) consisting of the amino acids of the CDRs of SEQ ID NO: 9 and a light chain having complementarity determining regions (CDRs) consisting of the amino acids of the CDRs of SEQ ID NO: 11.
2. The isolated antibody or antigen binding fragment thereof of claim 1 , wherein the isolated antibody comprises a heavy chain having the amino acid sequence depicted in SEQ ID NO:5 and a light chain having the amino acid sequence depicted in SEQ ID NO:7.
3. The isolated antibody or antigen binding fragment thereof of claim 1 , wherein the isolated antibody comprises a heavy chain having the amino acid sequence depicted in SEQ ID NO:9 and a light chain having the amino acid sequence depicted in SEQ ID NO:11.
4. The isolated antibody or antigen binding fragment thereof of claim 1 , wherein the isolated antibody comprises a heavy chain variable region consisting of the amino acids of the heavy chain variable region of SEQ ID NO: 5 and a light chain variable region consisting of the amino acids of the light chain variable region of SEQ ID NO: 7.
5. The isolated antibody or antigen binding fragment thereof of claim 1 , wherein the isolated antibody comprises a heavy chain variable region consisting of the amino acids of the heavy chain variable region of SEQ ID NO: 9 and a light chain variable region consisting of the amino acids of the light chain variable region of SEQ ID NO: 11.