Treatments for resistant acne
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.
1. A formulation, wherein the formulation comprises:
(i) 0.5 to 4 (% w/w) Besifloxacin.HCl (Equivalent to Besifloxacin);
(ii) 2 to 7 (% w/w) diethylene glycol monoethyl ether;
(iii) 0.1 (% w/w) Edetate disodium dehydrate (EDTA);
(iv) 2 to 10 (% w/w) glycerin;
(v) 0.9 to 1.75 (% w/w) hydroxyethyl cellulose;
(vi) 0 to 0.8 (% w/w) carbomer;
(vii) 0.3 to 0.7 (% w/w) phenoxyethanol;
(viii) 2 to 7 (% w/w) polyethylene glycol 400;
(ix) 0 to 0.5 (% w/w) sodium hyaluronate;
(x) sodium hydroxide; and
(xi) purified water.
2. The formulation of claim 1 , wherein the formulation further comprises adapalene.
3. The formulation of claim 1 , wherein the formulation further comprises a second anti-bacterial agent.
4. A formulation comprising:
(i) 1 to 4 (% w/w) Besifloxacin.HCl (Equivalent to Besifloxacin);
(ii) 5 (% w/w) diethylene glycol monoethyl ether;
(iii) 0.1 (% w/w) Edetate disodium dehydrate (EDTA);
(iv) 5 (% w/w) glycerin;
(v) 0.5 to 1.5 (% w/w) hydroxyethyl cellulose;
(vi) 0.3 to 1.2 (% w/w) carbomer;
(vii) 0.7 (% w/w) phenoxyethanol;
(viii) 5 (% w/w) polyethylene glycol 400;
(ix) 0 to 1 (% w/w) sodium hyaluronate;
(x) sodium hydroxide; and
(xi) purified water.
5. The formulation of claim 4 , wherein the formulation further comprises adapalene.
6. A method for treating a bacterial infection, comprising administering a therapeutic effective amount of a formulation of claim 1 to a subject in need thereof.
7. The method of claim 6 , wherein the bacterial infection is by an antibiotic-resistant bacterial strain.
8. The method of claim 6 , wherein bacterial infection is by P. acnes.
9. The method of claim 8 , wherein P. acnes is a drug resistant strain.
10. The method of claim 9 , wherein the drug resistant acne is not responding to a therapeutic amount of clindamycin, minocycline, doxycycline, tetracycline or erythromycin.
11. A method for treating a bacterial infection, comprising administering a therapeutic effective amount of a formulation of claim 4 to a subject in need thereof.
12. The method of claim 11 , wherein the bacterial infection is by an antibiotic-resistant bacterial strain.
13. The method of claim 11 , wherein bacterial infection is by P. acnes.
14. The method of claim 13 , wherein P. acnes is a drug resistant strain.
15. The method of claim 14 , wherein the drug resistant stain is not responding to a therapeutic amount of at least one of clindamycin, minocycline, doxycycline, tetracycline and erythromycin.
16. The formulation of claim 4 , wherein the formulation further comprises a second anti-bacterial agent.