Universal multidetection system for microplates

1. A device for analyzing one or more samples, the device comprising:

a receptacle support configured to support a microplate comprising a microplate well configured to hold a sample;

an incubation chamber configured to incubate the sample;

an imaging subsystem configured to image the sample on a cell level from below the sample, wherein the imaging subsystem is disposed substantially below the incubation chamber;

a non-imaging analyzing subsystem configured to analyze the sample on a well level, the non-imaging analyzing subsystem configured to provide at least one of a first measurement modality to measure an absorbance of the sample, a second measurement modality to measure fluorescence of the sample, and a third measurement modality to measure chemiluminescence of the sample;

a positioning subsystem configured to position the receptacle support for the non-imaging analyzing subsystem to analyze the sample and the imaging subsystem to image the sample; and

a temperature control subsystem configured to control temperature of an atmosphere around the sample to be different from a temperature of an atmosphere outside the device.

2. The device of claim 1 , wherein the positioning subsystem is common to both the imaging subsystem and the non-imaging analyzing subsystem.

3. The device of claim 1 , further comprising:

a housing that forms an exterior of the device and that encloses the non-imaging analyzing subsystem, the imaging subsystem, the incubation chamber, and the positioning subsystem.

4. The device of claim 1 , wherein the non-imaging analyzing subsystem is configured to provide the first measurement modality, the second measurement modality, and the third measurement modality.

5. The device of claim 1 , wherein (i) one of the imaging subsystem and the non-imaging analyzing subsystem and (ii) the receptacle support share a commonly controlled atmospheric composition.

6. The device of claim 1 , wherein the imaging subsystem, the non-imaging analyzing subsystem, and the receptacle support share a commonly controlled atmospheric composition.

7. The device of claim 1 , wherein the imaging subsystem comprises an objective to image the sample.

8. The device of claim 1 , wherein the imaging subsystem comprises a plurality of objectives mounted on a turret, the plurality of objectives mounted on the turret to be selectable to selectively image the sample.

9. The device of claim 1 , wherein the imaging subsystem comprises an imaging light source, and

wherein the non-imaging analyzing subsystem comprises at least one analyzing light source separate from the imaging light source.

10. The device of claim 1 , further comprising:

a processor configured to control operations of the non-imaging analyzing subsystem and the imaging subsystem.

11. The device of claim 1 , further comprising:

a user interface configured to receive a user input to control the operations of the non-imaging analyzing subsystem and the imaging subsystem.

12. The device of claim 1 , wherein the non-analyzing subsystem comprises a monochromator, the monochromator having a tunable wavelength for tuning a measurement wavelength of the at least one of the first measurement modality, the second measurement modality, and the third measurement modality.

13. The device of claim 1 , wherein a wavelength of the at least one of the first measurement modality, the second measurement modality, and the third measurement modality is continuously tunable.

14. The device of claim 1 , further comprising:

a gas control subsystem configured to control a composition of the atmosphere around the sample to be different from a composition of the atmosphere outside the device.

15. The device of claim 14 , wherein the composition of the atmosphere around the sample and the temperature of the atmosphere around the sample are conducive to cell viability.

16. The device of claim 14 , further comprising:

a processor configured to control operations of the non-imaging analyzing subsystem, the imaging subsystem, the positioning subsystem, the temperature control subsystem, and the gas control subsystem.

17. The device of claim 16 , further comprising:

a user interface configured to receive a user input to control the operations of the non-imaging analyzing subsystem, the imaging subsystem, the positioning subsystem, the temperature control subsystem, and the gas control subsystem.

18. A device for analyzing one or more samples, the device comprising:

a receptacle support configured to support a microplate comprising a microplate well configured to hold a sample;

an incubation chamber configured to incubate the sample; an imaging subsystem configured to image the sample on a cell level from below the sample, wherein the imaging subsystem comprises an objective to image the sample and the imaging subsystem is disposed substantially below the incubation chamber;

a non-imaging analyzing subsystem configured to analyze the sample on a well level, the non-imaging analyzing subsystem configured to provide at least one of a first measurement modality to measure an absorbance of the sample, a second measurement modality to measure fluorescence of the sample, and a third measurement modality to measure chemiluminescence of the sample;

a positioning subsystem configured to position the receptacle support for the non-imaging analyzing subsystem to analyze the sample and the imaging subsystem to image the sample;

a temperature control subsystem configured to control temperature of an atmosphere around the sample to be different from a temperature of an atmosphere outside the device;

a gas control subsystem configured to control a composition of the atmosphere around the sample to be different from a composition of the atmosphere outside the device;

wherein the non-imaging analyzing subsystem comprises a monochromator, the monochromator having a tunable wavelength for tuning a measurement wavelength of the at least one of the first measurement modality, the second measurement modality, and the third measurement modality.