IP Library › Granted Patent US 10,087,449
Granted Patent B2
US 10,087,449 · App. 15/302,280 · Granted Oct 2, 2018

Pharmaceutical composition for treating chronic kidney disease

Inventors: Takashi Ono (Toyonaka, JP); Katsutoshi Yamada (Toyonaka, JP); Norito Yoshimura (Toyonaka, JP); Toshihiro Shinosaki (Toyonaka, JP); Yoshinari Gahara (Toyonaka, JP); Hiroshi Itoh (Tokyo, JP); Shu Wakino (Tokyo, JP); Takeshi Kanda (Tokyo, JP); Kazuhiro Hasegawa (Tokyo, JP); Motoaki Komatsu (Tokyo, JP)
Assignees: SHIONOGI & CO., LTD.; KEIO UNIVERSITY
C12N15/1137C12Q1/48C12Y201/01001C12N2310/11C12N2310/14G01N2333/91017G01N2500/04
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Quick Facts
Patent No.
US 10,087,449
App. No.
15/302,280
Granted
Oct 2, 2018
Kind
B2
Abstract

This invention is related to a therapeutic agent for treating chronic kidney disease comprising a substance which inhibits the enzymatic activity of NNMT or suppresses NNMT gene expression, or a method for screening a therapeutic agent for treating chronic kidney disease which targets the NNMT enzyme or NNMT gene.

Claims (3)

1. A method of treatment comprising a step of administering a substance inhibiting the enzymatic activity of nicotinamide N-methyltransferase (NNMT) or suppressing NNMT gene expression for treating chronic kidney disease.

2. The method of claim 1 , wherein the substance inhibiting the enzymatic activity of NNMT or suppressing NNMT gene expression is a nucleic acid.

3. The method of claim 2 , wherein the nucleic acid is a siRNA, an antisense oligonucleotide or an expression vector thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2016
From: ONO, TAKASHI; YAMADA, KATSUTOSHI; YOSHIMURA, NORITO; SHINOSAKI, TOSHIHIRO; GAHARA, YOSHINARI; ITOH, HIROSHI; WAKINO, SHU; KANDA, TAKESHI; HASEGAWA, KAZUHIRO; KOMATSU, MOTOAKI
To: SHIONOGI & CO., LTD.; KEIO UNIVERSITY
Reel/Frame 041130/0159 →
Priority Claims (1)
JP 2014-078480 · Apr 7, 2014 · national
Continuity (1)
Related Publication 20170107521A1 · Apr 20, 2017