Modulators of toll-like receptors
Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
1. A compound of the Formula:
or a pharmaceutically acceptable salt thereof, wherein:
L 1 is —O—, —S—, —S(O) 2 —, or —S(O)—;
R 1 is alkyl;
X 1 is alkylene;
D is phenyl;
L 2 is alkylene;
n is 0;
R 4 and R 5 are each independently H; and
R 6 and R 7 , taken together with the nitrogen to which they are both attached, form an unsubstituted 4-6 membered heterocycle, which may contain one or more additional heteroatoms selected from N, O, or S.
2. The compound of claim 1 , wherein L 1 is —O—.
3. The compound of claim 1 , wherein X 1 is —CH 2 —.
4. The compound of claim 1 , wherein L 2 is —CH 2 —.
5. The compound of claim 1 , selected from the group consisting of:
or a salt thereof.
6. The compound of claim 1 , selected from the group consisting of:
or a salt thereof.
7. The compound of claim 1 , selected from the group consisting of:
or a salt thereof.
8. The compound of claim 1 , selected from the group consisting of:
or a salt thereof.
9. The compound of claim 1 , having the structure:
or a salt thereof.