Mixed metal compounds used as antacids
There is provided use of a mixed metal compound in the manufacture of medicament for neutralizing or buffering stomach acid, wherein the mixed metal compound contains at least one trivalent metal selected from iron (III) and aluminum and at least one divalent metal selected from of magnesium, iron, zinc, calcium, lanthanum and cerium, wherein (A) the mixed metal compound is of formula (I): M II 1-a M III a O b A n− c .zH 2 O (I) where M II is the at least one bivalent metal; M III is the at least one trivalent metal; A n− at least one n-valent anion; 2+a=2b+Σcn and Σcn<0.9a, and z is 2 or less, and/or (B) the mixed metal compound is provided in the form of a granular material comprising (i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound (ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.
1. A method of treating a disease characterized by elevated levels of stomach acid in a subject, comprising administering a therapeutically effective amount of a mixed metal compound to said subject, wherein the mixed metal compound comprises:
at least one trivalent metal selected from the group consisting of iron (III) and aluminum; and
at least one divalent metal selected from the group consisting of magnesium, iron, zinc, calcium, lanthanum, and cerium,
wherein
(A) the mixed metal compound is of formula (I):
M II 1-a M III a O b A n− c .z H 2 O (I)
where M II is the at least one divalent metal;
M III is the at least one trivalent metal;
A n− is at least one n-valent anion;
2+ a= 2 b+Σcn;
Σcn<0.9a; and
z is 2 or less.
2. The method according to claim 1 wherein in formula (I) z is 1.8 or less.
3. The method according to claim 1 wherein in formula (I) z is 1.5 or less.
4. The method according to claim 1 wherein in formula (I) a is from 0.1 to 0.4.
5. The method according to claim 1 wherein in formula (I) a is from 0.2 to 0.4.
6. The method according to claim 1 wherein in formula (I) a is from 0.2 to 0.34.
7. The method according to claim 1 wherein in formula (I) a is <0.3.
8. The method according to claim 1 wherein in formula (I) b is 1.5 or less.
9. The method according to claim 1 wherein in formula (I) b is 1.2 or less.
10. The method according to claim 1 wherein in formula (I) 0.03a<Σcn<0.7a.
11. The method according to claim 1 wherein in formula (I) 0.03a<Σcn<0.5a.
12. The method according to claim 1 wherein the compound of formula (I) is obtainable or is obtained by heating a starting material comprising a layered double hydroxide structure at a temperature of from 200° C. to 600° C.
13. The method according to claim 12 wherein the compound of formula (I) is obtainable or is obtained by heating a starting material comprising a layered double hydroxide structure at a temperature of from 250° C. to 500° C.
14. The method according to claim 12 wherein the starting material comprises a compound of formula (II):
M II 1-x M III x (OH) 2 A n− y .m H 2 O (II)
wherein M II is the at least one divalent metal;
M III is the at least one trivalent metal;
A n− is at least one n-valent anion;
x=Σyn;
0<x≤0.4;
0<y≤1; and
0<m≤10.
15. The method according to claim 1 , wherein the mixed metal compound is provided in the form of a granular material, comprising:
(i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound;
(ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water; and
(iii) no greater than 47% by weight, based on the weight of the granular material, of an excipient.
16. The method according to claim 15 wherein the mixed metal compound provided in the form of a granular material has less than 15% by weight crystallite-surface absorbed water.
17. The method according to claim 16 wherein the mixed metal compound has less than 10% by weight crystallite-surface absorbed water.
18. The method according to claim 16 wherein the mixed metal compound has less than 1% by weight crystallite-surface absorbed water.
19. The method according to claim 15 wherein the granular material comprises from 5 to 20% by weight of pregelatinised starch as excipient based on the weight of the granular material.
20. The method according to claim 15 wherein the granular material comprises from 1 to 15% by weight of cross linked polyvinylpyrrolidone as excipient based on the weight of the granular material.
21. The method according to claim 20 wherein the excipient comprises at least pregelatinised starch and cross linked polyvinylpyrrolidone.
22. The method according to claim 15 wherein at least 90% by weight of the granules of the granular material have a diameter less than 1180 micrometers.
23. The method according to claim 15 wherein the granular material is contained within a water resistant capsule.
24. The method according to claim 15 wherein a lubricant is provided between the granules.
25. The method according to claim 24 wherein the lubricant is or comprises magnesium stearate.
26. The method according to claim 15 wherein the granular material is coated with a water-resistant coating.
27. The method according to claim 26 wherein the water-resistant coating comprises at least 30% by weight of a butylated methacrylate copolymer.
28. The method according to claim 1 wherein the mixed metal compound is provided in a dosage unit containing the mixed metal compound in an amount of at least 200 mg.
29. The method according to claim 1 wherein the trivalent metal is at least iron (Ill).
30. The method according to claim 1 wherein the trivalent metal is iron (III).
31. The method according to claim 1 wherein the divalent metal is at least magnesium.
32. The method according to claim 1 wherein the divalent metal is magnesium.
33. The method according to claim 1 , wherein
the mixed metal compound contains iron (III) and magnesium, and is provided in the form of a granular material comprising:
(i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound;
(ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water; and
(iii) no greater than 47% by weight, based on the weight of the granular material, of an excipient.
34. The method according to claim 1 wherein the mixed metal compound is of formula (I):
M II 1-a M III a O b A n− c .z H 2 O (I)
wherein M II is magnesium;
M III is iron (III);
A n− is at least one n-valent anion;
2+ a= 2 b+Σcn;
Σcn<0.9a; and
z is 2 or less.
35. The method according to claim 1 wherein the mixed metal compound contains at least one of hydroxyl and carbonate anions.
36. A method for neutralizing or buffering stomach acid in a subject, comprising administering a therapeutically effective amount of a mixed metal compound to said subject, wherein the mixed metal compound contains at least one trivalent metal selected from the group consisting of iron (Ill) and aluminum and at least one divalent metal selected from the group consisting of magnesium, iron, zinc, calcium, lanthanum, and cerium,
wherein
(A) the mixed metal compound is of formula (I):
M II 1-a M III a O b A n− c .z H 2 O (I)
where M II is the at least one divalent metal;
M III is the at least one trivalent metal;
A n− is at least one n-valent anion;
2+a=2b+Σan;
Σcn<0.9a; and
z is 2 or less.
37. The method according to claim 1 wherein the condition or disease characterized by elevated levels of stomach acid is selected from the group consisting of peptic ulcers, heartburn, acid indigestion and acid reflux.
38. The method according to claim 37 wherein the condition or disease is peptic ulcers.
39. The method according to claim 36 , wherein the mixed metal compound is provided in the form of a granular material comprising:
(i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound;
(ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water; and
(iii) no greater than 47% by weight, based on the weight of the granular material, of an excipient.