Stabilized calcium phosphate and methods of forming same

1. A method of forming a stabilized calcium phosphate for use in dental or biomedical applications, the method comprising:

providing a first solution or dispersion including a calcium salt dissolved or dispersed in water or a suitable solvent;

reacting an organic phosphate having a polymerizable methacrylate or vinyl group with the first solution or dispersion at a pH of below 10 to form a second solution or dispersion;

providing a third solution or dispersion including a calcium salt dissolved or dispersed in water or a suitable solvent;

mixing the third solution or dispersion with the second solution or dispersion in order to form a solid calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group; and

decanting or filtering the solid calcium phosphate moiety from the solution or dispersion and drying the solid calcium phosphate moiety to form a powder.

2. The method of claim 1 , wherein the at least one pendant polymerizable group and the at least one organic functional group are the same group.

3. The method of claim 1 , wherein the calcium salt in the first solution or dispersion and/or in the third solution or dispersion includes calcium chloride, calcium hydroxide, calcium nitrate, or a combination thereof.

4. A method of forming a stabilized calcium phosphate for use in dental or biomedical applications, the method comprising:

providing a solution or dispersion including a calcium salt dissolved or dispersed in water or a suitable solvent; and

reacting bis[2-(methacryloyloxy)ethyl] phosphate with the solution or dispersion in order to form a calcium phosphate moiety having at least one pendant polymerizable group and at least one organic functional group.

5. The method of claim 1 , further comprising adding one or more inorganic phosphate sources to the organic phosphate to form a mixture, wherein the reacting includes reacting the mixture with the first solution or dispersion in order to form the second solution or dispersion.

6. The method of claim 5 , wherein the one or more inorganic phosphate sources includes phosphoric acid or its salt, ammonium phosphate, pyrophosphoric acid or its salt, or a combination thereof.

7. The method of claim 6 , wherein the phosphoric acid or its salt includes sodium salt of phosphoric acid.

8. The method of claim 1 , wherein the first solution or dispersion and/or the third solution or dispersion includes the calcium salt solubilized or dispersed in deionized water.

9. The method of claim 1 , wherein reacting the organic phosphate with the first solution or dispersion includes hydrolyzing the polymerizable methacrylate.

10. The method of claim 4 , further comprising adding one or more inorganic phosphate sources to the bis[2-(methacryloyloxy)ethyl] phosphate to form a mixture, wherein the reacting includes reacting the mixture with the solution or dispersion in order to form the calcium phosphate moiety.

11. The method of claim 10 , wherein the one or more inorganic phosphate sources includes phosphoric acid or its salt, ammonium phosphate, pyrophosphoric acid or its salt, or a combination thereof.

12. The method of claim 11 , wherein the phosphoric acid or its salt includes sodium salt of phosphoric acid.

13. The method of claim 4 , wherein the at least one pendant polymerizable group and the at least one organic functional group are the same group.

14. The method of claim 4 , wherein the calcium salt includes calcium chloride, calcium hydroxide, calcium nitrate, or a combination thereof.