Composite lumen with reinforcing textile and matrix
A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester.
1. A composite lumen, comprising:
a tubular textile formed of yarns having a first tensile strength, the tubular textile including interstitial openings therein; and
an elastomeric matrix material in which the tubular textile is embedded, the matrix material infiltrating the tubular textile to form a radially distentive vascular graft including a conduit having a bore with a diameter in the range of about 1 mm to about 6 mm and a sidewall substantially impermeable to liquid and configured to withstand physiological arterial pressure;
wherein the matrix material is a biodegradable or bioresorbable material having a second tensile strength that is lower than the first tensile strength,
wherein matrix material of the vascular graft promotes endogenous growth of mammalian neovascular tissue; and
wherein the matrix material comprises poly(glycerol sebacate).
2. The composite lumen of claim 1 , wherein the tubular textile is woven, knit or braided.
3. The composite lumen of claim 2 , wherein the tubular textile is a circular warp knit structure.
4. The composite lumen of claim 1 , wherein the tubular textile is formed of biodegradable or bioresorbable material.
5. The composite lumen of claim 4 , wherein the tubular textile comprises at least one composition selected from the group consisting of polylactic acid thermoplastic, polyglycolide, poly-L-lactic acid, poly(lactic-co-glycolic acid), poly(glycerol sebacate), polycaprolactone, 2-pyran-2-one-4,6-dicarboxylic acid, poly-p-dioxanone, polydioxanone, poly(1,8-octanediol citrate), and collagen.
6. The composite lumen of claim 1 , wherein the composite lumen facilitates pulsatile flow.
7. The composite lumen of claim 1 , wherein the tubular textile is configured to resist occlusion of the bore when an axial load is applied to the lumen.
8. The composite lumen of claim 1 , wherein the tubular textile is a braided textile.
9. The composite lumen of claim 8 , wherein the braided textile has a first braid angle along a first portion of its length and a second braid angle along a second portion of its length that is different from the first braid angle.
10. The composite lumen of claim 8 , wherein the braided textile comprises metal wires of at least two different diameters in the braid.
11. The composite lumen of claim 10 , wherein the metal wires having different diameters are spiraled in the same direction in the braid.
12. The composite lumen of claim 8 , wherein the braided textile comprises poly(glycerol sebacate).
13. The composite lumen of claim 1 wherein the vascular graft is cell-free.
14. The composite lumen of claim 1 , wherein the tubular textile consists of multi-filament biodegradable or bioresorbable yarns.
15. The composite lumen of claim 1 , wherein the tubular textile is braided at 10-120 picks per inch.
16. The composite lumen of claim 1 , wherein the tubular textile is braided with a braid angle between about 30 degrees to about 130 degrees.
17. A composite lumen, comprising:
a vascular graft having a bore, the bore having a diameter in the range of about 1 mm to about 6 mm, wherein the graft comprises:
a braided tubular textile comprising polyglycolide yarns; and
an elastomeric matrix comprising poly(glycerol sebacate) surrounding the braided tubular textile,
wherein the graft has a radially distentive sidewall substantially impermeable to liquid and is configured to withstand physiological arterial pressure, the elastomeric matrix having a tensile strength lower than a tensile strength of the polyglycolide,
wherein the elastomeric matrix promotes endogenous growth of mammalian neoartery tissue.
18. The composite lumen of claim 17 wherein the polyglycolide yarns are multi-filament yarns.
19. A composite lumen, comprising:
a braided tubular textile formed of multi-filament yarns having a first tensile strength,
the braided tubular textile infiltrated with a matrix material comprising poly(glycerol sebacate) to form a synthetic composite graft structure, the synthetic composite graft structure including a conduit having a bore with a diameter in the range of about 1 mm to about 6 mm and a sidewall substantially impermeable to liquid and configured to withstand physiological arterial pressure;
wherein the matrix material has a second tensile strength that is lower than the first tensile strength,
wherein matrix material of the vascular graft promotes endogenous growth of mammalian neovascular tissue.