IP Library Granted Patent US 10,274,419
Granted Patent B2
US 10,274,419 · App. 16/061,719 · Granted Apr 30, 2019

Container having a measuring cell

Inventors: Marek Hoehse (Goettingen, DE); Christian Grimm (Heiligenstadt, DE)
Assignee: Sartorius Stedim Biotech GmbH
G01N21/0303C12M23/28C12M41/36G01N2021/0321G01N2201/0245
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Quick Facts
Patent No.
US 10,274,419
App. No.
16/061,719
Granted
Apr 30, 2019
Kind
B2
Abstract

A container ( 1 ) has a measuring-cell housing ( 5 ) that protrudes into the container interior ( 2 ). The measuring-cell housing ( 5 ) has a measuring gap ( 6 ) bounded by two opposed spaced-apart lateral surfaces ( 8, 9 ), and a connecting surface ( 10 ) connects the lateral surfaces ( 8, 9 ). Each lateral surface ( 8, 9 ) has an optical window ( 11, 12 ). A first optical fiber (15, 15′) is arranged before the first window ( 11 ) and a second optical fiber ( 17, 17 ′) is arranged before the second window ( 12 ). Receiving channels ( 14, 16, 18 ) are arranged before the windows ( 11, 12, 13 ) and subsequently can be fit with the optical fibers ( 15, 15′, 17, 17′, 19 ) from the outside. The measuring-cell housing ( 5 ) having the windows ( 11, 12, 13 ) and the receiving channels ( 14, 16, 18 ) is connected fixedly to the wall ( 3 ) of the container interior ( 2 ).

Claims (46)

1. A container ( 1 ) having a measuring-cell housing ( 5 ) of an optical measuring cell ( 4 ) that protrudes into the container interior ( 2 ) of the container, wherein the measuring-cell housing ( 5 ) has a measuring gap ( 6 ), which is bounded by two opposite-facing lateral surfaces ( 8 , 9 ) spaced apart from each other at a distance ( 7 ) and by a connecting surface ( 10 ) that connects the lateral surfaces ( 8 , 9 ), wherein the lateral surfaces ( 8 , 9 ) each have an optical window ( 11 , 12 ), and wherein at least one first optical fiber ( 15 , 15 ′) can be arranged before the first window ( 11 ) and at least one second optical fiber ( 17 , 17 ′) can be arranged before the second window ( 12 ),

wherein

the measuring-cell housing ( 5 ) has receiving channels ( 14 , 16 , 18 ) arranged before the windows ( 11 , 12 , 13 ) for receiving the at least one optical fiber ( 15 , 15 ′, 17 , 17 ′, 19 ) in each case,

the receiving channels ( 14 , 16 , 18 ) can be subsequently fitted from the outside with the optical fibers ( 15 , 15 ′, 17 , 17 ′, 19 ), and

the measuring-cell housing ( 5 ) having the windows ( 11 , 12 , 13 ) and the receiving channels ( 14 , 16 , 18 ) is fixedly connected to the wall ( 3 ) of the container interior ( 2 ).

2. The container of claim 1 ,

wherein

at their ends facing the windows ( 11 , 12 , 13 ), the receiving channels ( 14 , 14 ′″, 16 , 16 ′″, 18 ′″) are oriented orthogonally to the windows ( 11 , 12 , 13 ).

3. The container of claim 1 ,

wherein

the measuring-cell housing ( 5 ) has a third optical window ( 13 ) on its connecting surface ( 10 ) and

that before the third optical window ( 13 ) there is arranged a third receiving channel ( 18 ) that can be fitted from the outside with at least one third optical fiber ( 19 ).

4. The container of claim 1 ,

wherein

at their ends facing away from the windows ( 11 , 12 , 13 ), the receiving channels ( 14 , 14 ′″, 16 , 16 ′″, 18 , 18 ′″) have receiving openings ( 26 , 27 , 28 ) the longitudinal axes ( 29 , 30 , 31 ) of which extend parallel to one another.

5. The container of claim 1 ,

wherein

the measuring-cell housing ( 5 ) having windows ( 11 , 12 , 13 ) and receiving channels ( 14 , 16 , 18 ) constitutes a single-use part of the optical measuring cell ( 4 ) and

that the optical fibers ( 15 , 15 ′, 17 , 17 ′, 19 ), along with connected light sources and/or sensors and evaluation and control electronics, constitute a reusable part of the optical measuring cell ( 4 ).

6. The container of claim 1 ,

wherein

the optical windows ( 11 , 12 , 13 ) are lenses.

7. The container of claim 1 ,

wherein

for transmission purposes light 20 from a light source can be conducted via the at least one first fiber ( 15 ) in the first receiving channel ( 14 , 14 ′″), through the first window ( 11 ) into the measuring gap ( 6 ) with a sample volume, and further via the second window ( 12 ) and the at least one second fiber ( 17 ) arranged in the second receiving channel ( 16 , 16 ′″), to a detector.

8. The container of claim 7 ,

wherein

at least one pinhole aperture is arranged between the second window ( 12 ) and the second fiber ( 17 ) arranged in the second receiving channel ( 16 ).

9. The container of claim 1 ,

wherein

for reflection purposes, light 20 ′ from a light source can be conducted via a first fiber ( 15 ′) in the first receiving channel ( 14 ), through the first window ( 11 ) into the measuring gap ( 6 ) with a sample volume, and can be conducted back as reflected light ( 22 ′) from the sample volume via the first window ( 11 ) and a second fiber ( 17 ′) arranged in the first receiving channel ( 14 ), to a detector.

10. The container of claim 1 ,

wherein

for transflection purposes, light 20 ′ from a light source can be conducted via a first fiber ( 15 ′) in the first receiving channel ( 14 ), through the first window ( 11 ) into the measuring gap ( 6 ) with a sample volume, and be further conducted via the second window ( 12 ) in the second receiving channel ( 16 ) onto a diffusely reflecting surface ( 23 ), and be conducted back as reflected light ( 22 ″), via the first window ( 11 ) and a second fiber ( 17 ′) arranged in the first receiving channel ( 14 ), to a detector.

11. The container of claim 10 ,

wherein

the reflecting surface ( 23 ) is arranged at the free end of a dummy fiber ( 26 ) inserted into the second receiving channel ( 16 ).

12. The container of claim 3 ,

wherein

scattered light ( 22 ) from a sample volume can be conducted via the third optical window ( 13 ) and the third optical fiber ( 19 ) arranged in the third receiving channel ( 18 , 18 ′″), to a detector.

13. The container of claim 1 ,

wherein

the container ( 1 ) is a single-use bioreactor or a single-use mixing bag.

14. The container of claim 1 ,

wherein

the receiving channels ( 14 ′″, 16 ′″, 18 ′″) form a common spatial depression ( 32 ) in which the optical fibers ( 15 , 17 , 19 ) are fastened by means of brackets ( 33 , 34 , 35 ) and are arranged before the windows ( 11 , 12 , 13 ).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 13, 2018
From: HOEHSE, MAREK; GRIMM, CHRISTIAN
To: SARTORIUS STEDIM BIOTECH GMBH
Reel/Frame 046067/0953 →
Priority Claims (1)
DE 10 2015 122 745 · Dec 23, 2015 · national
Continuity (1)
Related Publication 20180372617A1 · Dec 27, 2018