IP Library Granted Patent US 10,288,599
Granted Patent B2
US 10,288,599 · App. 15/002,828 · Granted May 14, 2019

Systems and devices for molecule sensing and method of manufacturing thereof

Inventors: Brett Gyarfas (Chandler, AZ); Stuart Lindsay (Phoenix, AZ); Pei Pang (Tempe, AZ)
Assignee: Arizona Board of Regents on behalf of Arizona State University
G01N33/48721C12Q1/6869G01N27/44791G03F7/20
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Quick Facts
Patent No.
US 10,288,599
App. No.
15/002,828
Granted
May 14, 2019
Kind
B2
Abstract

Embodiments of the disclosure are directed to a device for molecule sensing. In some embodiments, the device includes a first electrode separated from a second electrode by a dielectric layer. The first electrode comprises a large area electrode and the second electrode comprises a small area electrode. At least one opening (e.g., trench) cut or otherwise created into the dielectric layer exposes a tunnel junction therebetween whereby target molecules in solution can bind across the tunnel junction.

Claims (19)

1. A device for detecting one or more target molecules comprising:

a first electrode having a first thickness;

a dielectric layer covering the first electrode;

a second electrode having a second thickness, the second electrode being separated from the first electrode by the dielectric layer, wherein the surface area of the second electrode is less than the surface area of the first electrode; and

at least one trench cut or etched through at least the second electrode and dielectric layer and configured to expose a junction between the electrodes to facilitate connection of one or more target molecules with the first and second electrodes.

2. The device according to claim 1 , wherein the second electrode comprises a wire.

3. The device according to claim 1 , further comprising at least one adhesion layer arranged beneath at least one of the first and second electrodes.

4. The device according to claim 1 , wherein the dielectric layer covers substantially all of the first electrode save for a contact area for the first electrode, the contact area configured for connection to a contact pad at the edge of the device.

5. The device of claim 1 , further comprising first molecules for forming a non-covalent bond with the one or more target molecules, wherein the electrodes are chemically functionalized with the first molecules.

6. The device of claim 1 , further comprising a passivating layer between about 20 nm and about 500 nm in thickness covering a substantial portion of the surface of the electrodes.

7. The device of claim 1 , further comprising a passivating layer substantially encapsulating the device, the layer being between about 20 nm and about 500 nm in thickness.

8. The device according to claim 1 , wherein the at least one trench includes a plurality of trenches.

9. The device of claim 1 , wherein the second electrode is arranged in a cross or “T” configuration relative to the first electrode so as to separate one or more junctions therebetween.

10. The device of claim 1 , wherein the at least one trench has a width or diameter of between about 2.5 nm to about 3 nm.

11. A device for detecting one or more target molecules comprising:

a first electrode, the first electrode deposited on a supporting layer;

a dielectric layer covering the first electrode;

a second electrode separated from the first electrode by the dielectric layer, wherein the surface area of the second electrode is less than the surface area of the first electrode; and

at least one trench cut or etched through at least the second electrode and dielectric layer and configured to expose a junction between the electrodes to facilitate connection of one or more target molecules with the first and second electrodes.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 9, 2021
From: ARIZONA STATE UNIVERSITY, TEMPE CAMPUS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 056819/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2017
From: GYARFAS, BRETT; LINDSAY, STUART; PANG, PEI
To: ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 043517/0888 →
Continuity (3)
Continuation 14051142 · Oct 10, 2013
Provisional Application 61711981 · Oct 10, 2012
Related Publication 20160258925A1 · Sep 8, 2016