IP Library › Granted Patent US 10,308,608
Granted Patent B2
US 10,308,608 · App. 16/047,179 · Granted Jun 4, 2019

Histone deacetylase inhibitors

Inventors: Shripad Bhagwat (Novato, CA); Gregory Luedtke (Royal Oaks, CA); Alexander Bridges (Saline, MI)
Assignee: BIOMARIN PHARMACEUTICAL INC.
C07D211/46C07D205/04C07D207/12C07D207/14C07D211/58C07D223/08C07D223/12C07D451/02C07D451/04C07D451/06
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Quick Facts
Patent No.
US 10,308,608
App. No.
16/047,179
Granted
Jun 4, 2019
Kind
B2
Abstract

Provided herein are compounds and methods for inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

Claims (15)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The compound or salt of claim 1 , having a structure:

3. The compound or salt of claim 1 , having a structure:

4. The compound or salt of claim 1 , having a structure:

5. The compound or salt of claim 1 , having a structure:

6. The compound or salt of claim 1 , having a structure:

7. The compound or salt of claim 1 , having a structure:

8. The compound or salt of claim 1 , having a structure:

9. The compound or salt of claim 1 , having a structure:

10. The compound or salt of claim 1 , having a structure:

11. The compound or salt of claim 1 , having a structure:

12. The compound or salt of claim 1 , having a structure:

13. The compound or salt of claim 1 , having a structure:

14. The compound or salt of claim 1 , having a structure:

Assignments (2)
SECURITY INTEREST Recorded Apr 27, 2026
From: BIOMARIN PHARMACEUTICAL INC.; AMICUS THERAPEUTICS, INC.
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 075493/0968 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 10, 2018
From: BHAGWAT, SHRIPAD; LUEDTKE, GREGORY; BRIDGES, ALEXANDER J.
To: BIOMARIN PHARMACEUTICAL INC.
Reel/Frame 046617/0182 →
Continuity (3)
Continuation 15740437
Provisional Application 62188139 · Jul 2, 2015
Related Publication 20180370915A1 · Dec 27, 2018