Visual prosthesis employing virtual neural electrode arrays
The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.
1. An implantable medical device for electrically stimulating portions of a brain that relate to vision, the implantable medical device comprising:
a foldable conformal flexible substrate configured to be inserted into a fluid-filled intracranial cavity proximate to a component of a visual pathway of the brain; and
a plurality of electrodes, arranged in a three-dimensional array, fabricated on the foldable conformal flexible substrate,
wherein at least a portion of the plurality of electrodes is configured to apply an electrical stimulation to the component of the visual pathway responsive to the implantable medical device receiving an electrical signal from a second device.
2. The implantable medical device of claim 1 , wherein the plurality of electrodes are arranged to have an inter-electrode spacing between 10 micrometers and 50 micrometers.
3. The implantable medical device of claim 1 , wherein at least a portion of the three-dimensional array has an electrode density at or above 100,000 electrodes per square centimeter.
4. The implantable medical device of claim 1 , wherein at least a portion of the three-dimensional array has an electrode density at or above 200,000 electrodes per square centimeter.
5. The implantable medical device of claim 1 , wherein the flexible substrate comprises at least one of polyimide, polyether ether keytone (PEEK), polyacrylic, epoxy, fluoropolyerms, and/or transparent conductive polyester film.
6. The implantable medical device of claim 1 , wherein the implantable medical device is configured to be implanted into a venous sinus proximate to a visual cortex.
7. The implantable medical device of claim 1 , wherein the implantable medical device is configured to be implanted into a ventricular compartment of the brain proximate to optic radiations, a lateral geniculate body, or a visual cortex.
8. The implantable medical device of claim 1 , wherein the at least a portion of the plurality of electrodes is configured to apply the electrical stimulation to the component of the visual pathway simultaneously with recording from the component of the visual pathway.
9. The implantable medical device of claim 1 , wherein the foldable conformal flexible substrate is adapted for deployment through a narrow cylindrical channel.
10. The implantable medical device of claim 9 , wherein the foldable conformal flexible substrate is collapsible for deployment through the narrow cylindrical channel.
11. The implantable medical device of claim 1 , wherein the electrical signal corresponds to an image acquired by an external camera.
12. The implantable medical device of claim 1 , wherein the applied electrical stimulation generates a visual precept in the visual pathway.
13. The implantable medical device of claim 1 , wherein at least a first portion of the plurality of electrodes is configured to apply an electrical stimulation to the component of the visual pathway at the same time as a second portion of the plurality of electrodes is configured to record electrical activity from the component of the visual pathway.
14. An implantable medical device for electrically stimulating portions of a brain that relate to vision, the implantable medical device comprising:
a foldable conformal flexible substrate configured to be inserted into a fluid-filled intracranial cavity proximate to a component of a visual pathway of the brain; and
a plurality of electrodes, arranged in a three-dimensional array, fabricated on the foldable conformal flexible substrate,
wherein the foldable conformal flexible substrate is adapted to conform to one or more surfaces of the fluid-filled intracranial cavity by way of a pressure fit.
15. The implantable medical device of claim 14 , wherein the foldable conformal flexible substrate comprises a skeleton member having one or more loops, each loop further comprising a panel embedded therein.
16. The implantable medical device of claim 15 , wherein the foldable conformal flexible substrate is in a folded configuration when the one or more loops are oriented towards each other, and the foldable substrate is in an unfolded configuration when the one or more loops are oriented planar to each other.