Polymorphic forms and process
The present invention relates to a polymorph of a compound of formula (I) This polymorph is particularly suitable in treating IPF by pulmonary administration.
1. A polymorph of a compound of formula (I)
wherein the polymorph is 3,3′-Dideoxy-3,3′-bis-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1,1′-sulfanediyl-di-β-D-galactopyranoside and wherein:
the polymorph has a polymorphic form selected from the group consisting of a polymorphic form 2 as identified in the XRPD diffractogram in FIG. 3 , a polymorphic form 3 as identified in the XRPD diffractogram in FIG. 4 , a polymorphic form 4 as identified in the XRPD diffractogram in FIG. 5 , a polymorphic form 5 as identified in the XRPD diffractogram in FIG. 6 , and a polymorphic form 6 as identified in the XRPD diffractogram in FIG. 7 .
2. The polymorph of claim 1 wherein the compound of formula (I) is 3,3′-Dideoxy-3,3′-bis-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1,1′-sulfanediyl-di-β-D-galactopyranoside as a hydrate and the polymorphic form is selected from the group consisting of polymorphic form 2, polymorphic form 5, and polymorphic form 6.
3. The polymorph of claim 2 wherein the 3,3′-Dideoxy-3,3′-bis-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1,1′-sulfanediyl-di-β-D-galactopyranoside hydrate contains 3-5% water (weight %).
4. The polymorph of claim 1 wherein the polymorph is micronized.
5. The polymorph of claim 4 wherein the polymorph is micronized to a size that can reach the bronchioles and/or the alveoli of the human.
6. A pharmaceutical composition comprising the polymorph of claim 1 , and optionally a pharmaceutically acceptable additive.
7. A process of making a polymorph of claim 1 comprising the steps of suspending or dissolving 3,3′-Dideoxy-3,3′-bis-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1,1′-sulfanediyl-di-β-D-galactopyranoside in an organic solvent and then making the polymorph by temperature cycling, crash cooling, anti-solvent addition, evaporation, or a combination thereof.
8. A method for treatment of pulmonary fibrosis in a human comprising administering to the lung tissue of the human an amount of the polymorph of claim 1 effective to treat said pulmonary fibrosis.
9. The method of claim 1 wherein the administration is carried out by a dry powder inhaler.
10. The method of claim 9 wherein the administration is carried out by a monodose dry powder inhaler.
11. The method of claim 8 wherein the polymorph is administered to the bronchioles and/or the alveoli of the human.
12. The method of claim 8 wherein the amount is a once daily amount from 0.15 mg to 50 mg.
13. The method of claim 12 , wherein the amount is a once daily amount selected from the group consisting of: 0.15 mg to 0.50 mg, 0.50 mg to 0.75 mg, 0.75 mg to 1.25 mg, 1.25 mg to 1.5 mg, 1.5 mg to 1.75 mg, 1.75 mg to 2 mg, 2 mg to 2.25 mg, 2.25 mg to 2.5 mg, 2.5 mg to 2.75 mg, 2.75 mg to 3 mg, 3 mg to 5 mg, 5 mg to 7 mg, 7 mg to 8 mg, 8 mg to 10 mg, 10 mg to 20 mg and 20 mg to 50 mg.
14. A method for treatment of pulmonary fibrosis in a human comprising administering to the lung tissue of the human an amount of the polymorph of claim 2 effective to treat said pulmonary fibrosis.
15. A method for treatment of pulmonary fibrosis in a human comprising administering to the lung tissue of the human an amount of the polymorph of claim 3 effective to treat said pulmonary fibrosis.
16. A method for treatment of pulmonary fibrosis in a human comprising administering to the lung tissue of the human an amount of the polymorph of claim 4 effective to treat said pulmonary fibrosis.